You have accessJournal of UrologyCME1 May 2022MP36-13 ANALYSIS OF PRIMARY NON-FUNCTION, DELAYED GRAFT FUNCTION AND OVERALL GRAFT SURVIVAL FOR EXPANDED CRITERIA DONORS' KIDNEYS Monica Peradejordi Font, Antoni Vilaseca Cabo, Lluis Peri Cusi, Mireia Musquera Felip, Tarek Ajami Fardoun, Claudia Mercader Barrull, Angel Ruiz Arranz, David Paredes Zapata, Fritz Diekmann, and Antonio Alcaraz Asensio Monica Peradejordi FontMonica Peradejordi Font More articles by this author , Antoni Vilaseca CaboAntoni Vilaseca Cabo More articles by this author , Lluis Peri CusiLluis Peri Cusi More articles by this author , Mireia Musquera FelipMireia Musquera Felip More articles by this author , Tarek Ajami FardounTarek Ajami Fardoun More articles by this author , Claudia Mercader BarrullClaudia Mercader Barrull More articles by this author , Angel Ruiz ArranzAngel Ruiz Arranz More articles by this author , David Paredes ZapataDavid Paredes Zapata More articles by this author , Fritz DiekmannFritz Diekmann More articles by this author , and Antonio Alcaraz AsensioAntonio Alcaraz Asensio More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002590.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The use of kidneys from expanded criteria donors (ECD) is increasing due to donor shortage. Predicting the outcome of these grafts is still a challenge. The aim of this study is to determine which factors are related to primary non-function (PNF), delayed graft function (DGF) and overall graft survival for kidneys retrieved from expanded criteria donors (ECD). METHODS: From January 2017 to December 2019 we retrospectively evaluated the pre-transplantation renal biopsy results and the pulsatile machine renal vascular resistance (RVR) of 97 kidneys from ECD that were implanted in our hospital. Those kidneys came from 40 donors after brain death and 57 from donors after cardiac death (6 Maastricht II, 50 Maastricht III and 1 Maastricht IV). The recipients’ evolution was analyzed. The association of the studied factors with PNF and DGF of the graft were studied with a logistic univariate regression. A Kaplan-Meier model was used to study its relationship with overall graft survival. RESULTS: The renal biopsy score was the only analyzed variable that presented with a statistically significant relation with PNF (OR 1.86, p<0.05), specifically the % of glomerulosclerosis (OR 1.11, p<0.05) and the grade of interstitial fibrosis (OR 5.36, p<0.05). Regarding DGF, the age of the donor (OR 0.90, p<0.05), serum creatinine >1.5 mg/dl (OR 11.57, p<0.05) and donation after cardiac death (OR 3.1 p<0.05) showed statistical difference. The recipient’s age and having diabetes were also related to developing DGF (OR 0.95, p<0.05 and OR 2.83, p<0.05). None of the biopsy results or the perfusion machine parameters resulted in statistically significant differences. Overall graft survival was inferior for grafts with RVR≥0.5 and/or renal biopsy score≥4 (p<0.05) (Figure 1). Presenting with DGF was not related to a worse graft survival (p=0.114). CONCLUSIONS: In this unicenter study, factors associated with PNF were related to graft biopsy results, whereas DGF was influenced by clinical donor and recipient characteristics. Overall survival of the graft is inferior for those grafts with RVR≥0.5 or renal biopsy score≥4. Source of Funding: There is no source of funding to disclose © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e602 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Monica Peradejordi Font More articles by this author Antoni Vilaseca Cabo More articles by this author Lluis Peri Cusi More articles by this author Mireia Musquera Felip More articles by this author Tarek Ajami Fardoun More articles by this author Claudia Mercader Barrull More articles by this author Angel Ruiz Arranz More articles by this author David Paredes Zapata More articles by this author Fritz Diekmann More articles by this author Antonio Alcaraz Asensio More articles by this author Expand All Advertisement PDF DownloadLoading ...
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