Humans utilize water for a variety of purposes, which needs the treatment. The study explores the use of blended cactus and Moringa seed powder as coagulants to reduce phosphate and nitrate levels in surface water. Samples was collected from the Kitto River in the Oromiya region, Jimma, Ethiopia, were analyzed using various tools. A jar test was used to investigate the study using blended powder of cactus and Moringa under different operating parameters. In this study, pH (5−9), settling time (30–50 min), stirring speed (40–50 rpm), and dosage ratio (50 %C to 50 %M, 25 % C to 75 %M, and 75 % C to 25 % M) were used to analyze the removal % of NO3-, and PO43-. The highest removal efficiency was achieved with a dosage ratio of 3 (75 % M: 25 % C), a pH of 7, a settling time between 40 to 50 min, and a stirring speed of less than 50 rpm. The removal efficiencies closely matched the predicted values (92.6 %, 88.31 %) and actual values (99.46 %, 92.32 %) for PO43- and NO3- respectively. Hence, the finding showed that blended cactus with Moringa seed increases the effectiveness of phosphate and nitrate reduction.