In a double blind study the effect of ibuprofen and naproxen on swelling following surgical removal of impacted mandibular molar (M3) was evaluated on (48) patients. The patients were divided into three groups according to medication given for each group. The postoperative swelling at the area of surgery was measured by two methods namely, computerized photography and conventional facebow. The measurements performed at day (2) and day (7) postoperatively. The results showed that both ibuprofen and naproxen not reduced the expected swelling significantly in day (2) post-operatively comparing to control placebo group, but significant difference was noticed between the effect of ibuprofen and control group in day (7) post-operatively.