Removal Of Acetaminophen Research Articles

Coconut Shell Biochar for the Removal of Acetaminophen and Ciprofloxacin in Low Concentrations: Single and Competitive Adsorption Studies

Coconut Shell Biochar for the Removal of Acetaminophen and Ciprofloxacin in Low Concentrations: Single and Competitive Adsorption Studies

Correction: Yu et al. Nitrogen Doped Porous Biochar/β-CD-MOFs Heterostructures: Bi-Functional Material for Highly Sensitive Electrochemical Detection and Removal of Acetaminophen. Molecules 2023, 28, 2437

Following publication, concerns were raised regarding the peer-review process related to the publication of this article [...]

Preparation of gray ZnO1−x photocatalyst containing oxygen vacancies for the highly efficient removal of nitric oxide and acetaminophen

Preparation of gray ZnO1−x photocatalyst containing oxygen vacancies for the highly efficient removal of nitric oxide and acetaminophen

The Staged Photocatalytic Reactor in the Removal of Acetaminophen: Aspects of Adsorption and Photocatalysis.

The efficiency of a staged photocatalytic reactor prototype was evaluated on a semi-pilot scale with the removal of acetaminophen, for which anatase particles were synthesized by Sol-Gel and impregnated on rectangular plates of clay. X-ray diffraction and Energy Dispersive X-ray Fluorescence patterns show that the final composite is made up of Al2O3 (14 %), SiO2 (41 %), CaO (3 %) TiO2 (34 %), and Fe2O3 (7 %). The impregnation method favors the dispersion of Anatase on the surface of the adsorbent. TiO2-Anatase/Clay, classified as a macro-porous solid with H3-type hysteresis loops by N2 physisorption. Adsorption processes are improved when using TiO2-Anatase/Clay compared to using TiO2-Anatase. The external mass transfer has a greater influence on the removal rate. The dimensionless parameters of the Biot number indicate there are no limitations due to the diffusive effect on the interior of the particle. The evaluation of the kinetic data under the Langmuir-Hinshelwood equation shows a decrease in efficiency as the initial concentration increases. The acetaminophen molecule shows destabilization in the structure of the aromatic ring with a visible decrease in the signals of this functional group evaluated by High-Performance Liquid Chromatography and Raman Spectroscopy.

Strong enhancement on acetaminophen elimination and effective control of chlorinated/brominated by-products generation in heat/peroxymonosulfate system with sodium perborate

The application of heat/peroxymonosulfate (PMS) system was severely constrained due to the high O–O bond dissociation energy of PMS and the high risk of forming halogenated by-products. Interestingly, this work found that sodium perborate (NaBO3) could significantly improve the removal of acetaminophen in heat/PMS system. The proposed NaBO3/heat/PMS system could achieve 100 % elimination efficiency of ACT within 15 min and exhibited an excellent pseudo-first-order rate constant (kobs), which was 35.6-folds higher than heat/PMS system. 1O2 and OH were identified as the primary reactive species in NaBO3/heat/PMS system. NaBO3 can hydrolyze to produce BO2− and H2O2, where BO2− can subsequently hydrolyze to generate B(OH)4− having strong buffer capacity. The HOOB(OH)3/HOOBO, characterized by their asymmetric O–O bonds, can be formed through the reaction of PMS with BO2− and B(OH)4−. 1O2 mainly originated from the reactions of PMS with the formed HOOB(OH)3/HOOBO, and OH primarily originated from the cleavage of O–O bond in HOOB(OH)3/HOOBO and PMS. Three removal pathways of acetaminophen were proposed. The toxicity of acetaminophen solution was reduced following the treatment using NaBO3/heat/PMS system. Humic acid, CO32−, Br− and Cl− suppressed the acetaminophen removal in NaBO3/heat/PMS system, while initial pH, NO3− and SO42− had minimal impact. Notably, the kobs of acetaminophen removal in actual waters (e.g., groundwater and lake water) were greater than that in ultrapure water. More importantly, NaBO3/heat/PMS system can effectively control the formation of chlorinated/bromine by-products, which was achieved by converting HClO to inert B(OH)3OCl− with B(OH)4−, and reducing the HBrO and HClO to Br– and Cl– with deprotonated H2O2 (HO2−). This study proposed a promising approach for improving heat/PMS system and underscored its application potential in treating water containing Cl−and Br−.

Enhancing acetaminophen removal through persulfate activation with ZnCl2-SPI biochar: A study on reactive oxygen species contribution according to acetaminophen concentration

This study investigated the effect of acetaminophen (ACP) removal through the ZnCl2-SPI/persulfate process and evaluated the production of reactive oxygen species (ROS) based on ACP concentration. ACP removal efficiency reached 96 % within 5 min, regardless of the initial concentration (40 μM and 200 μM). The change in pH had a minimal effect on the removal efficiency, and the reactivity improvement increased the removal rate at pH 4 and 10. The persulfate-to-ACP ratio significantly influenced ACP removal, with the minimum ratio required for effective ACP removal being 5. The scavenger test results showed that the effect of O2•− radicals prevailed when ACP concentration was 40 μM, whereas the effect of 1O2 prevailed when ACP concentration was 200 μM. This indicates that ROS contribution depends on the persulfate-to-ACP ratio. When this ratio was high, ZnCl2-SPI and persulfate reacted to generate O2•− radicals via the radical pathway. Conversely, when this ratio was low, ACP and persulfate reacted to generate 1O2 via the nonradical pathway. The difference in these mechanisms was analyzed through electrochemical analysis, confirming that ACP and persulfate reacted via a coupling effect. In conclusion, the ROS generated in the ZnCl2-SPI/persulfate process varied depending on the persulfate-to-ACP ratio, and the ROS generation path can be selectively controlled by adjusting this ratio.

Acetaminophen removal using porous activated carbon derived from corn cob: optimization and mass transfer modelling

AbstractBACKGROUNDAcetaminophen, also known as paracetamol, has been notably detected in aquatic environments, including wastewater, surface water and drinking water, causing significant concern within the scientific and environmental research communities. This study focuses on two main objectives: (i) optimizing corn cob‐based activated carbon (CCAC) through response surface methodology for the adsorption of acetaminophen and (ii) simulating the acetaminophen adsorption process using the polymath mass transfer (PMT) model.RESULTSThe optimized CCAC was prepared via physiochemical activation under microwave radiation (265 W power) for 6 min, with a KOH impregnation ratio of 0.50 g g−1. This process resulted in a high Brunauer–Emmett–Teller surface area of 976.29 m2 g−1, accompanied by a corresponding pore volume of 0.39 cm3 g−1 and a pore diameter of 2.38 nm. The adsorption study, employing differential initial concentrations (ranging from 5 to 30 mg L−1) of acetaminophen, revealed a substantial adsorption capacity of 22.43 mg g−1 (74.77%) at 30 °C and 20.74 mg g−1 (69.13%) at pH 6. The PMT model indicated an adsorption capacity (Qm) of 21.14 mg g−1, with an error of 5.75%, demonstrating high precision compared to the experimental result. Additionally, the calculated R2 values equal to or above 0.90 indicated strong agreement between the PMT model and experimental data.CONCLUSIONThus, applying the PMT model proved to be economical and cost‐effective, providing accurate predictions on surface area during adsorption performance compared to the time‐consuming and costly process of conducting characterizations. © 2024 Society of Chemical Industry (SCI).

Acetaminophen removal by peroxymonosulfate catalyzed by C and O co-doped graphitic carbon nitride in synthetic secondary treatment effluent matrix

Catalytic oxidation using carbonaceous materials and peroxymonosulfate (PMS) has attracted attention because of high potential in pharmaceuticals removal. For successful field applications, it is essential to identify the components and characteristics in real water matrices affecting the performance, though it has hardly been elaborated. Therefore, acetaminophen (ACT) removal by C and O co-doped graphitic carbon nitride (COCN) and PMS was investigated in synthetic secondary treatment effluent (SSTE) and compared to that in deionized water (DIW). ACT removal was significantly suppressed in SSTE (20.33 %) compared to that in DIW (94.20 %) under 10 mg/L ACT, 100 mg/L COCN, and 0.5 mM PMS. However, it was enhanced greatly with increasing COCN and/or PMS dose. The reactive species were the same in SSTE and DIW, of which 1O2 from O2− dominantly contributed. However, the amount of them was considerably lower in SSTE than in DIW. ACT removal was slightly affected by the anions in SSTE, such as Cl−, SO42−, and NO3−, at 1.41 × 10−3–0.71 mM. But it was suppressed greatly by 0.71 mM phosphates and by 10 mg/L humic acid and natural organic matter, via consuming hydrophobic and aromatic fractions. It is strongly suggested that the reactivity of COCN/PMS in SSTE was dominantly affected by raised pH and scavenging O2− reducing DOM, which decreased 1O2 generation. The results would significantly contribute to successful practical applications of catalytic systems.

Magnetic adsorbents from co‐pyrolysis of non‐woody biomass and red mud for water decontamination

AbstractRed mud (RM) and non‐woody biomass are both underutilized resources for renewable composite materials, which could be used in environmental decontamination processes. This study aims to investigate the efficacy of co‐pyrolyzing non‐woody biomass with RM to produce a magnetic biochar composite. When pyrolyzed, RM is reduced to magnetic iron while the non‐woody biochar is responsible for the adsorption of organic compounds. Ibuprofen, acetaminophen, methyl orange, and methylene blue were used as test compounds to investigate the overall adsorptive capacity of the composite and to determine the possible adsorption mechanisms of biochar produced from RM pyrolyzed with switch grass, phragmites, rice husk, and miscanthus. The composite produced from a 1 to 1 mixture of RM and miscanthus showed the highest adsorption capacity with 13.8 and 8.34 mg/g of ibuprofen and acetaminophen adsorbed, respectively, which is attributed to its greater ‐interactions as a result of lower surface oxygen sites. Different ratios of RM to biomass were also tested for the production of the miscanthus composite, where it was found that the 1:2 ratio showed the best overall adsorption with 25.9 mg/g removal of acetaminophen, surpassing the miscanthus biochar's at 17.9 mg/g.

Removal of acetaminophen from wastewater using a novel bimetallic La/Th metal-organic framework: Kinetics, thermodynamics, isotherms, and optimization through Box-Behnken design

Acetaminophen (ACT), a common drug pollutant, has been effectively removed from wastewater by a novel adsorbent called La/Th-MOF. This adsorbent is made of stacked nanorods of 2-methyl imidazole with lanthanum and thorium. La/Th-MOF, which is characterized by sophisticated techniques including SEM, XRD, and BET analysis, has a mesoporous assembly with a 1.23 nm pore size and a capacious surface area of 2226.93 m2/g, which facilitates effectual adsorption. The adsorption tests, which were impacted by factors such as pH levels, ACT concentration, and contact time, fit into a pseudo-second-order chemisorption kinetic model and with the Langmuir isotherm, suggesting homogenous monolayer adsorption. The material in question demonstrated a noteworthy maximum adsorption capability of 339.75 mg/g for ACT, indicating its probable as a feasible and economical adsorbent for the mitigation of pharmaceutical contamination in wastewater. Our results designate that pH levels have an important influence on the efficacy of ACT absorption by La/Th-MOF, with an acidic pH 5 environment being most favorable for maximal adsorption at a material dosage of 0.02 g. It was discovered that the adsorption procedure was endothermic. Using pseudo-second-order kinetic models and the Langmuir isotherm, which both fit the experimental data very well, to explain the adsorption kinetics. A chemisorption mechanism was found to be predominant throughout the process, as specified by the predicted adsorption energy of 22.62 kJ/mol. In addition, optimized the influencing parameters by using the Box-Behnken design (BBD) and response surface methodology (RSM), which improved process efficiency. La/Th-MOF, has a remarkable half-life, as demonstrated by six rounds of adsorption and desorption without a discernible decline in performance. Research endeavors aimed at elucidating the interplay between La/Th-MOF and ACT hint to several plausible points of contact that could contribute to the adsorption procedure, such as hydrogen bonding, π-π interactions, pore filling or electrostatic forces. This study, which is innovative in its use, reveals the exceptional efficacy of La/Th-MOF in wastewater purification using ACT extraction. An astounding 339.75 mg/g of optimal adsorption capability was attained at an acidic pH of 5. This highlights how the La/Th-MOF can be used in practice to treat pharmaceutical pollutants found in water sources.

Co and N co-doped carbon nanotubes catalyst for PMS activation: Role of non-radicals

Metal-nitrogen-carbon catalysts demonstrate significant advantages in the remediation of water environments. Here, a cobalt-nitrogen-carbon catalyst (Co(1.5)-NCNT) with abundant Co-Nx active sites and excellent electron transfer capability was prepared via a simple method and used to activate peroxymonosulfate (PMS) for efficient removal of Acetaminophen (APAP). As a result, the Co(1.5)-NCNT/PMS system removed 100% of APAP within 10 min. The reaction process characterization suggested that PMS is adsorbed by Co(1.5)-NCNT to form a Co(1.5)-NCNT-PMS complex, which accelerates PMS activation. Additionally, the singlet oxygen (1O2) generated by PMS activation can effectively attack electron-rich contaminants, facilitating the rapid degradation of APAP. Furthermore, Co(1.5)-NCNT/PMS exhibits strong environmental adaptability, maintaining high catalytic performance in complex water environments for the effective degradation of various pollutants. This study elucidates the properties of Co-Nx active sites in the Co(1.5)-NCNT/PMS system and the activation mechanism of PMS, providing new insights into the removal of pollutants through non-radical pathways.

Accessing biochemical shifts in a novel Scenedesmus strain via acetaminophen detoxification: Experiment utilizing Box-Behnken optimization and isotherm analysis

Acetaminophen's inherent solubility and hydrophilic nature facilitate its accumulation in aquatic ecosystems. Herein, Scenedesmus dimorphus IITISM-DIX1 demonstrates efficient acetaminophen removal, concurrently serving as a substrate for lipid biosynthesis. Employing Box-Behnken design, optimization of parameters like pH, light duration and concentration of acetaminophen influencing its elimination is executed. Characterization of pre- and post-algal biomass involves FE-SEM, FTIR, and BET analysis. Kinetic and adsorption analyses reveal pseudo-first-order kinetics (R2 = 0.99) and adherence to the Freundlich isotherm (R2 = 0.94). FTIR spectroscopy demonstrates subtle shifts in IR bands post-sorption, indicative of biomass involvement in adsorption processes. Biodegradation and biosorption serve as the main removal pathways, facilitated by exopolysaccharides, generating by-products such as 4-aminophenol, hydroquinone, and formic acid. The Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) values obtained for the Freundlich isotherm validate it as the optimal model, indicating heterogeneous multilayered sorption with efficiency ranging from 44% to 100%. Additionally, exposure to acetaminophen-contaminated media leads to biochemical alterations in Scenedesmus dimorphus IITISM-DIX1. The findings of this study unveil the first elucidated pathway for acetaminophen degradation by any Scenedesmus species, delivering essential knowledge about microalgae-mediated acetaminophen degradation and lipid enrichment mechanisms.

Peanut-shell-derived biochar mediated peracetic acid activation for the elimination of acetaminophen via an electron-transfer regime

Biochar-based heterogeneous activation of disinfectant peracetic acid (PAA) is an attractive and promising route for micropollutant elimination in water, yet the underlying activation mechanism is still scarce. In this study, PAA was first catalyzed by peanut shell-derived biochar (PSBC) to degrade acetaminophen (ACP). The enhancement of ACP removal was triggered by PAA activation, while the coexisted H2O2 was unexpected to be an adverse factor owing to its occupation of active sites. Higher dosages of PSBC (0–0.30 g/L) and PAA (0–4.0 mM) favored the destruction of ACP, and the activation energy (41.8 kJ/mol) of PSBC/PAA system is lower than that of the thermal or microwave activated PAA system. The experimental results demonstrate that the metastable complex PSBC-PAA* dominated ACP elimination through an electron transfer mechanism. The surface –OH group was validated to be the key active site for PAA activation. Surprisingly, the actual water matrices present a negligible effect and the promotion of HCO3− ion on ACP removal was even observed. Based on the identified intermediates, the transformation of ACP was further proposed with the formation of polymeric products via oxidative coupling reactions. The findings not only shed light on the mechanism of PAA activated by the biochar-based catalyst but also contribute to a novel perspective on future PAA studies in contamination remediation.

Boosting acetaminophen degradation in water by peracetic acid activation: A novel approach using chestnut shell-derived biochar at varied pyrolysis temperatures

In this study, biochar derived from chestnut shells was synthesized through pyrolysis at varying temperatures from 300 °C to 900 °C. The study unveiled that the pyrolysis temperature is pivotal in defining the physical and chemical attributes of biochar, notably its adsorption capabilities and its role in activating peracetic acid (PAA) for the efficient removal of acetaminophen (APAP) from aquatic environments. Notably, the biochar processed at 900 °C, referred to as CN900, demonstrated an exceptional adsorption efficiency of 55.8 mg g−1, significantly outperforming its counterparts produced at lower temperatures (CN300, CN500, and CN700). This enhanced performance of CN900 is attributed to its increased surface area, improved micro-porosity, and a greater abundance of oxygen-containing functional groups, which are a consequence of the elevated pyrolysis temperature. These oxygen-rich functional groups, such as carbonyls, play a crucial role in facilitating the decomposition of the O–O bond in PAA, leading to the generation of reactive oxygen species (ROS) through electron transfer mechanisms. This investigation contributes to the development of sustainable and cost-effective materials for water purification, underscoring the potential of chestnut shell-derived biochar as an efficient adsorbent and catalyst for PAA activation, thereby offering a viable solution for environmental cleanup efforts.

Azadirachta indica leaf extract based green-synthesized ZnO nanoparticles coated on spent tea waste activated carbon for pharmaceuticals and personal care products removal

Pharmaceuticals and personal care products (PPCPs) are emerging contaminants in aqueous systems, posing threat to both human health and environment. In prior research, predominant focus has been on examining various adsorbents for removing PPCPs from single-pollutant systems. However, no study has delved into simultaneous adsorption of PPCPs multi-pollutant mixture. This study evaluates performance of Azadirachta indica leaf extract-based green-synthesized ZnO nanoparticles coated on spent tea waste activated carbon (ZTAC) for removing sulfadiazine (SZN) and acetaminophen (ACN). Adsorption investigations were conducted in single-component (ACN/SZN) and binary-component (ACN + SZN) systems. The synthesized ZTAC was characterized using SEM, XRD, FTIR, EDX, porosimetry and pHpzc analysis. The study examines impact of time (1–60 min), dose (0.2–4 g/L), pH (2–12) and PPCPs concentration (1–100 mg/L) on ACN and SZN removal. Various kinetic and isotherm models were employed to elucidate mechanisms involved in sorption of PPCPs. Furthermore, synergistic and antagonistic aspects of sorption process in multi-component system were investigated. ZTAC, characterized by its crystalline nature and surface area of 980.85 m2/g, exhibited maximum adsorption capacity of 47.39 mg/g for ACN and 34.01 mg/g for SZN under optimal conditions of 15 min, 3 g/L and pH 7. Langmuir isotherm and pseudo-second-order kinetic model best-fitted the experimental data indicating chemisorption mechanism. Removal of ACN and SZN on ZTAC demonstrated synergistic nature, signifying cooperative adsorption. Overall, valorization of ZTAC offers effective and efficient adsorbent for elimination of PPCPs from wastewater.

Sulfur and chloride co-doped g-C3N4 in photocatalytic peroxymonosulfate activation for enhanced acetaminophen removal: Combination of experiments and DFT calculations

As a green photocatalyst with simple synthesis method, excellent electronic structure, and metal-free properties, the deficiencies of pristine graphitic carbon nitride, such as high electron transfer resistance and narrow energy band gap, inhibit its photocatalytic activity to some extent. In this paper, we synthesized a sulfur and chlorine co-doped g-C3N4 (SCl-CN) capable of efficient photocatalytic activation of peroxymonosulfate (PMS) by calcining a mixture of ammonium chloride and thiourea. By means of DFT calculation, the contribution of sulfur and chlorine to photogenic electron hole separation was discussed. The electrostatic potential of SCl-CN and the adsorption model between SCl-CN and PMS were deduced, and the activation mechanism of PMS was further analyzed. According to the calculated results, the incorporation of sulfur and chlorine tuned the electronic configuration of the material and intensified the interactions between SCl-CN and PMS. It is shown that free and non-free radicals act simultaneously in the SCl-CN/PMS/Vis system. This study provides a new idea for the study of photocatalytic activation of PMS by non-metallic co-doped carbon nitride.

Modulating the electronic structures of Fe3C-based catalyst by surface sulfidation to facilitate H2O2 activation

The performance of Fe-based heterogeneous Fenton catalysts is apparently affected by the electron density of Fe active site. Herein, we modulate the active site electronic density of the Fe3C-based catalyst by surface sulfidation to improve H2O2 activation property. After sulfidation, the removal of acetaminophen (APAP) increased from 27.1% to 100%, and the degradation rate constant kobs of APAP increased 5.44-fold. Sulfidation enhances the utilization of H2O2 and improves the generation of active species. Theoretical calculations demonstrated that sulfidation increases the electron density of Fe sites and lowers the band gap between the d-band center and Fermi energy level, facilitating electron transfer and H2O2 activation. The change in cleavage position of H2O2 from O-H to O-O after sulfidation provides additional evidence for the increased generation of •OH. These results elucidate the promoting effect of sulfidation on heterogeneous Fenton catalysts and provide a strategy for improving the performance of catalyst and contaminant removal.

Photocatalytic and antibacterial activity of green synthesized and immobilized zinc oxide nanoparticles for the removal of sulfadiazine and acetaminophen: Effect of operational parameters and degradation pathway

The present research investigates the photocatalytic degradation of pharmaceutical compounds acetaminophen (ATP) and sulfadiazine (SFZ), using zinc oxide nanoparticles synthesized by green method (N-ZnO). The nanoparticles were synthesized from the extract of neem leaf (Azadirachta indica) and were characterized using spectroscopic techniques. The effect of operational parameters like pH, light intensity, catalyst dosage and initial concentration was also studied. The degradation pathway of ATP and SFZ was analyzed using LCMS. Since the recovery and reuse of nanoparticles from water is difficult, the ZnO nanoparticles were immobilized by coating onto activated carbon generated from spent tea waste (TAC). At optimum conditions, 100% removal of ATP and SFZ was observed using ZnO nanoparticles coated on spend tea leaf activated carbon (N-ZnO@TAC). The antibacterial studies of N-ZnO, TAC and N-ZnO@TAC revealed that N-ZnO nanoparticles exhibited more antibacterial properties when compared to the other two. Hence green synthesized ZnO nanoparticles are found to exhibit excellent antibacterial and photocatalytic properties for the removal of emerging contaminants.

Sustainable removal of caffeine and acetaminophen from water using biomass waste-derived activated carbon: Synthesis, characterization, and modelling

The removal of caffeine (CFN) and acetaminophen (ACT) from water using low-cost activated carbons prepared from artichoke leaves (AAC) and pomegranate peels (PAC) was reported in this paper. These activated carbons were characterized using various analytical techniques. The results showed that AAC and PAC had surface areas of 1203 and 1095 m2 g−1, respectively. The prepared adsorbents were tested for the adsorption of these pharmaceuticals in single and binary solutions. These experiments were performed under different operating conditions to evaluate the adsorption properties of these adsorbents to remove CFN and ACT. AAC and PAC showed maximum adsorption capacities of 290.86 and 258.98 mg g−1 for CFN removal, 281.18 and 154.99 mg g−1 for the ACT removal over a wide pH range. The experimental equilibrium adsorption data fitted to the Langmuir model and the kinetic data were correlated with the pseudo-second order model. AAC showed the best adsorption capacities for the removal of these pharmaceuticals in single systems and, consequently, it was tested for the simultaneous removal of these pollutants in binary solutions. The simultaneous adsorption of these compounds on AAC was improved using the central composite design and response surface methodology. The results indicated an antagonistic effect of CFN on the ACT adsorption. AAC regeneration was also analyzed and discussed. A statistical physics model was applied to describe the adsorption orientation of the tested pollutants on both activated carbon samples. It was concluded that AAC is a promising adsorbent for the removal of emerging pollutants due to its low cost and reusability properties.

Accelerated Fe(III)/Fe(II) cycle for ultrafast removal of acetaminophen by a novel W18O49 co-catalytic Fe3+/H2O2 fenton-like system

The traditional Fenton reaction always encounters the restriction that the solution pH needs to be strictly regulated, and Fe2+ is easy to self-decompose but not easy to regenerate. Fe3+ is relatively stable but its reaction with H2O2 is super-restricted. A novel strategy for the co-catalytic effect of W18O49 on the enhancement of Fe3+/H2O2 reaction activity was presented in this study. The W18O49/Fe3+/H2O2 system achieved a 94% acetaminophen (ACE) degradation rate within 5 min, which was much higher than the Fe3+/H2O2 system (48%), and W18O49 also showed excellent repeatability. Quenching experiment and ESR proved that the removal of ACE mainly depended on 1O2 (leading role) and •OH, which was different from the previously reported Fenton/Fenton-like system dominated by •OH. Accelerated Fe2+/Fe3+ cycling controlled by variational W4+/W6+ and intermediate •OH stabilization by oxygen vacancy for enhancing the breaking of O-O bond in H2O2 to produce more radicals was the dual driving force in the W18O49/Fe3+/H2O2 system for enhanced oxidation activity. The W18O49/Fe3+/H2O2 system has favorable tolerance to a wide range of pH and anions, which provides a feasible strategy for the practical application of the Fenton-like system.