Performance of an innovative configuration of enclosed cuboid compartments-photosynthesis microbial desalination cell (EC-PMDC) for synchronous sewage treatment, desalination of seawater, and renewable energy recovery. Bioanode and biocathode were inoculated with jumbled bacterial species and mixed microalgae, respectively. The results demonstrated that maximum removal efficiency of organic content as chemical oxygen demand (COD) from the sewage was up to 99 %, whereby the total dissolved solids (TDS) removal efficiency from seawater was 91 %, accompanied with maximum power generation of 975 mW/m3. Kinetic study of bacterial growth in the EC-PMDC demonstrated excellent agreement between experimental data and those predicted by Blackman, Monod, Moser, and Teissier models with coefficients of determination (R2) equal to 0.98, 0.97, 0.96, and 0.97, respectively. Significant harmonization was obtained between the experimental results of voltage, current density, and power density with those predicted by the adopted electrochemical model. For comparison purposes, a conventionally designed photosynthesis microbial desalination cell (SC-PMDC) consisted of triple sequential cuboid compartments was setup. It was fed with similar influents as for the EC-PMDC. Maximum efficiencies of COD and TDS removals were 99 % and 81 %, respectively accompanied with power recovery of 420 mW/m3 were observed in the SC- PMDC indicating the superiority of EC-PMDC design.