This study focuses on simulation of the radiation shielding parameters for nickel-based superalloys: Inconel 600, 718 and 725 superalloys. The partial interactions, mass attenuation coefficient value (µ m), effective atomic number value (Z eff), effective electron density value (N el) and half value layer (HVL) at photon energy ranging of 1 keV–100 GeV, were estimated theoretically by WinXCom software program. Moreover, buildup factors (energy absorption buildup factor and exposure buildup factor) were determined using geometrical progression (G-P) fitting method for energy ranging 0.015–15 MeV at deep penetration 1–40 mfp (mean free path).Also, fast neutron removal cross sections (ΣR) were simulated by partial density method at energy ranging from 2 to 12 MeV. The results found that nickel-based superalloy Inconel 725 had excellent radiation shielding property. The study also brings the significance of these samples by comparing with standard commercial concrete.