Remission Of Chronic Lymphocytic Leukemia Research Articles

Remission of chronic lymphocytic leukemia after smallpox vaccination

Remission of chronic lymphocytic leukemia after smallpox vaccination

Membrane difference in peripheral blood lymphocytes from patients with chronic lymphocytic leukemia and Hodgkin's disease.

Lymphocytes were isolated from the peripheral blood of 21 normal persons and 66 patients with chronic lymphocytic leukemia (CLL), CLL in remission, Hodgkin's disease, Hodgkin's disease in remission, various other tumors, or cardiovascular diseases; The lymphocytes were studied for cap formation and agglutinability by concanavalin A, and for cell attachment to the surface of a petri dish. The frequency of cap formation was lowest in lymphocytes from patients with untreated Hodgkin's disease (2.1 plus or minus 0.8%), next lowest in lymphocytes from patients with CLL who were or were not under treatment (7,0 plus or minus 1;3%), and also low in Hodgkin's disease in remission (10.6 plus or minus 1.2%). The frequencies of cap formation by lymphocytes from patients with various other tumors (19.1 plus or minus 2.5%), with CLL in remission (24.0 plus or minus 0.9%), and with nonmalignant diseases (26.0 plus or minus 2.2%) were more similar to the frequency found in lymphocytes from normal persons (29.4 plus or minus 2.8%). Lymphocytes from all the patients, including those in remission, showed a higher degree of agglutinability by concanavalin A than lymphocytes from normal persons. Cell attachment to a petri dish was highest with CLL, next highest with CLL in remission, and low for normal persons and all the other patients. Lymphocytes from normal persons that consisted predominantly of thymus-derived cells gave similar results to isolated normal bone marrow-derived cells. The results indicate that there were different changes in the surface membrane of lymphocytes from patients with CLL, CLL in remission, Hodgkin's disease, and Hodgkin's disease in remission, and that the patients in clinical remission still showed abnormalities in their lymphocytes.

Changes in the surface membrane of lymphocytes from patients with chronic lymphocytic leukemia and Hodgkin's disease.

AbstractLymphocytes were isolated from the peripheral blood of 15 normal persons, 15 patients with chronic lymphocytic leukemia (CLL), 10 patients with Hodgkin's disease and 3 patients with CLL in remission. The cells were studied for cap formation and agglutinability by concanavalin A, and for cell attachment to the surface of a Petri dish. The percentages of lymphocytes with a cap were 25–34% for normal persons, 5–9% for CLL patients whether under treatment or not, 1–3% for untreated patients with Hodgkin's disease and about a normal percentage for CLL in remission. Vinblastine in all cases induced only about a 1.5‐ to 2‐fold increase in the percentage of cells with a cap. Agglutinability by concanavalin A was low for normal persons and high for all the patients including those with CLL in remission. Cell attachment to the Petri dish was low for normal persons and Hodgkin's disease patients, intermediate for CLL in remission and high for patients with CLL. Similar results for normal persons were obtained with peripheral blood lymphocytes that were predominantly T cells and with isolated normal B cells. Compared to lymphocytes from normal persons, lymphocytes from CLL patients were therefore different in cap formation, agglutinability and cell attachment; those from Hodgkin's disease in cap formation and agglutinability; and those from CLL in remission in agglutinability and cell attachment. These results indicate that there are different surface membrane changes in lymphocytes from patients with CLL, Hodgkin's disease and CLL in remission. It is suggested that these membrane changes may be useful as an aid in diagnosis.

Radiation-induced remissions in chronic lymphocytic leukemia.

Radiation-induced remissions in chronic lymphocytic leukemia.

Complete remission in chronic lymphocytic leukemia and leukolymphosarcoma.

Seven instances of complete remission, confirmed by bone marrow aspiration, were observed among 202 patients with chronic lymphocytic leukemia and leukolymphosarcoma treated during a 10-year period. Review of these cases and of 10 instances reported by others revealed that complete remission of disseminated lymphoproliferative disease was observed more frequently after x-ray irradiation than after other modalities of treatment and that many remissions followed treatment which might be considered inadequate. The authors conclude that host factors must have played a major role in these cases but that in almost all of them improvement was clearly related to the administration of specific therapy. A characteristic pattern of response was associated with each therapeutic modality and x-ray irradiation produced the most rapid correction of circulating lymphocytosis.