Remarkable Antifungal Effect Research Articles

Effects of Carvacrol on Sister Chromatid Exchanges in Human Lymphocyte Cultures

Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. The genotoxicity test was performed with carvacrol in two donors. On the other hand, inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.

Synthesis of 1‐Azabicyclo[3.3.1]nona‐3,6‐diene Derivatives by a Modified Prins Reaction

AbstractIntramolecular electrophilic cyclization reactions were performed with 1‐(3‐oxo‐3‐phenylpropyl)‐1,2,5,6‐tetrahydropyridine derivatives 1a–p in strong acids to give 4,6‐diphenylsubstituted 1‐azabicyclo[3.3.1]nonadienes 2a–p. Some qualitative observations were made on substituents and reaction conditions influencing the ring closure reaction. Naphthylsubstituted starting compounds 3a, b were converted into pentacyclic compounds 4a, b which represent a new ring system, suggesting the occurrence of a carbenium ion intermediate in the ring closure reaction. Some of the compounds 2a–p show remarkable antifungal and antibacterial effects. magnified image