Abstract Constructing the health indicator (HI) and predicting the remaining useful life (RUL) are essential steps in bearing health management. Some prediction methods depend on prior information about HIs, especially when these indicators are generated by deep learning models. However, acquiring such prior information can be challenging in practical applications. This paper introduces a novel unsupervised adaptive density-based clustering filter (UADCF) for RUL prediction of bearings, which operates without the need for prior knowledge. Firstly, a post-hoc interpretation HI model (PIHIM) is proposed to characterize the deep learning constructed HIs from the perspective of what the deep learning has done. Then, leveraging the classical density-based clustering algorithm, we introduce the UADCF for unsupervised estimation of model parameters, which can dynamically adjust density parameters based on the current conditions. Finally, we develop a prediction framework combining PIHIM and UADCF, enabling unsupervised RUL prediction of bearings. The experimental studies validate the effectiveness of the proposed method.