REM-related Obstructive Sleep Apnea Research Articles

Comparison of REM-related obstructive sleep apnea with NREM-related obstructive sleep apnea in terms of possible disease complications and demographic indicators

Comparison of REM-related obstructive sleep apnea with NREM-related obstructive sleep apnea in terms of possible disease complications and demographic indicators

REM-Related Obstructive Sleep Apnea: Prevalence and Definitions Using Decision Trees Models

REM-Related Obstructive Sleep Apnea: Prevalence and Definitions Using Decision Trees Models

Incidence of Sleep Bruxism in Different Phenotypes of Obstructive Sleep Apnea.

(1) Background: Sleep bruxism (SB) is a common sleep behavior. Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder with potential long-term major neurocognitive and cardiovascular sequelae. Although the co-occurrence of SB and OSA has been described previously, the exact relationship remains unclear. The present study aimed to evaluate the incidence of SB in different phenotypes of OSA. (2) Methods: The participants of this study were adult patients referred to the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at the Wroclaw Medical University. They underwent a single-night video polysomnography in a sleep laboratory. The data related to common OSA phenotypes were analyzed in two separate groups of patients: body position related (n = 94) and rapid eye movement (REM) related (n = 85). (3) Results: The obtained results showed that the incidence of SB and severe SB was higher for body position-related OSA phenotype (p < 0.05 for all comparisons). No statistically significant differences were observed for REM-related OSA phenotype (p > 0.05 for all comparisons). (4) Conclusions: Body position-related OSA phenotype seems to be associated with higher SB and severe SB incidence, but the relationship is not independent. However, in the light of the unclear relationship between SB and sleep-disordered breathing, the topic needs further study.

Characteristics of rapid eye movement-related obstructive sleep apnea in Thai patients

Obstructive sleep apnea (OSA) is a common sleep disorder that has been associated with cardiovascular consequences. Rapid eye movement (REM)-related obstructive sleep apnea (OSA) is a subtype of OSA which is characterized by apneas or hypopneas predominately during REM sleep. The factors associated with REM-related OSA are still unclear. We aimed to determine the prevalence and associated characteristics of REM-related OSA in Thai patients. A total of 408 patients’ charts were retrospectively reviewed. Demographic and anthropometric characteristics, comorbidities and polysomnographic data were obtained. The patients were divided into two groups: REM-related OSA and non-stage specific OSA. REM-related OSA was defined as an apnea–hypopnea index (AHI) ≥ 5 per hour, with a ratio of REM-AHI to NREM-AHI > 2, and NREM-AHI < 15 per hour. The prevalence of REM-related OSA was 21.6%. AHI and arousal index were both lower in REM-related OSA than in non-stage specific OSA. REM-related OSA was significantly associated with females (OR 2.35, 95% CI 1.25–4.42, p = 0.008), age < 60 years (OR 2.52, 95% CI 1.15–5.55, p = 0.021), and mild OSA (OR 17.46, 95% CI 9.28–32.84, p < 0.001). In conclusion, age < 60 years, female gender, and mild severity of OSA were associated with REM-related OSA.

Prevalence and Risk Factors for Rapid Eye Movement-Related Obstructive Sleep Apnea in Children.

ObjectivesDifferent pathophysiological mechanisms and the distribution of respiratory events among rapid eye movement (REM) and non-rapid eye movement (NREM) sleep modulate the effect of obstructive sleep apnea (OSA). We aimed to study the prevalence and risk factors for REM-related OSA in children.Study DesignRetrospective, cross-sectional study.MethodsWe recruited 366 children with OSA confirmed by polysomnography (PSG) over a 5-year period. REM-related OSA is defined by an obstructive apnea-hypopnea index (OAHI) in the REM sleep ≥2× than during NREM sleep.ResultsThe prevalence of REM-related OSA in children was 50.3%. Children with REM-related OSA were more likely to be female (P = 0.042), and had lower prevalence of adenotonsillar hypertrophy (P = 0.043) compared with children with other OSA subtypes. Children with REM-related OSA slept longer in the supine position (P = 0.003), had shorter duration of NREM1 sleep (P = 0.018), lower nadir SpO2 (P = 0.005), and a higher oxygen desaturation index 3% (ODI3%) (P = 0.014), and lower arousal index (P = 0.034) compared with other OSA subtypes. Female gender and supine sleep was the independent risk factors for REM-related OSA.ConclusionThe prevalence of REM-related OSA was 50.3%. OAHIREM should be considered as an important parameter in future clinical research studies done in children with OSA.

Progress in clinical research of REM-related obstructive sleep apnea

REM-related obstructive sleep apnea （REM-OSA） refers to apneas and hypopneas in which most respiratory events occur during REM. The total AHI of REM-OSA is low compared to NREM-OSA, but the duration of apnea hypopnea events is longer and the oxygen saturation is lower. Only focusing on the total AHI value will miss the diagnosis of REM-OSA, and even some patients with severe hypoxemia cannot be effectively treated.REM-OSA may be an early manifestation of OSA, and active early recognition and intervention may benefit patients.The pathophysiology and mechanism of REM-OSA are still unclear. In this article, we reviewed the existing REM-OSA related research.

Impact of rem-related obstructive sleep apnea therapy on anxiety, depression and daytime sleepiness

Impact of rem-related obstructive sleep apnea therapy on anxiety, depression and daytime sleepiness

Proportion of rapid eye movement sleep related obstructive sleep apnea (REM related OSA) in patients with sleep disordered breathing: A cross sectional study.

Background and Objectives:Obstructive sleep apnea (OSA) during rapid eye movement (REM) stage of sleep is gaining importance in recent years. This study was done to determine the proportion of REM-related OSA and its associated polysomnographic features.Methods:One hundred forty-two patients were included in the study. REM-related OSA was defined based on previously established broad and strict criteria (REM apnea–hypopnea index [AHI]/non-REM [NREM] AHI ratio ≥2 and REM AHI >5 with NREM AHI <5, respectively), and its association with polysomnographic features was studied using appropriate statistical tools.Results:The proportion of REM-related OSA in the study was 56.3% and 25.3% as per broad and strict criterion, respectively. The REM-related OSA group had a mean younger age (47.4 ± 13.2 years) as compared to NREM-related OSA group (52.6 ± 15.8 years). Females (34 out of 45; 75.6%) were more likely to have REM-related OSA as compared to males (46 out of 107; 47.4%). Supine AHI, arousal index, oxygen desaturation index, length of the longest event, and the lowest oxygen saturation recorded during sleep had a significant association with REM-related OSA. 74% of patients with overall AHI <5 and 87% patients with overall AHI 5 to 15 satisfied the criteria for REM-related OSA as per broad criterion.Conclusion:REM-related OSA was quite prevalent in the study population (56.3%) and was more common in the mild and moderate severity subgroups of OSA.

Rapid eye movement related obstructive sleep apnea: Where do we stand?

Rapid eye movement (REM) related obstructive sleep apnea (OSA) is defined by the presence of episodes of apnea or hypopnea predominantly or exclusively during REM sleep. Epidemiology of this disorder shows a complex interaction with age, sex, and body mass index. The prevalence is variable and depends on the criteria used to define this disorder. Moreover, the clinical significance of this entity remains poorly defined. However, episodes of apnea or hypopnea encountered during REM sleep are longer and are associated with a more profound drop in oxygen saturation than non-REM sleep. Likewise, this disorder may be independently associated with hypertension and poor glycemic control. More importantly, positive airway pressure therapy as currently prescribed may not treat the majority of apnea episodes during REM sleep. The treatment is further complicated by the different definitions used for the diagnosis of this disorder and the lack of consensus if patients with this diagnosis should be treated if their overall apnea-hypopnea index does not meet the threshold for the clinical diagnosis of OSA. The definition and treatment used for the diagnosis and management of REM-related OSA needs to be standardized. Moreover, a consensus needs to be developed as to whether patients with this disorder should be treated if their overall apnea-hypopnea index does not meet the threshold for the clinical diagnosis of OSA. Further investigation may help answer if this disorder is independently associated with neurocognitive and cardiometabolic adverse outcomes and help guide the therapeutic approach.

REM-related obstructive sleep apnea and vertigo: A retrospective case-control study.

In recent population-based case-control studies, sleep apnea was significantly associated with a higher incidence (hazard ratio, 1.71) of vertigo and the risk of tinnitus was found to increase 1.36 times in patients with sleep apnea. The possibility that obstructive sleep apnea (OSA) might affect neurotological consequences was not noticed, until studies using polysomnography (PSG) for these patients. The purpose of this study was to investigate the relationship between vertigo and OSA. The collected data among patients from May 1st, 2018 to October 31th, 2018 at Shuang Ho Hospital. Eligibility criteria included an age older than 20 years, a diagnosis of obstructive sleep apnea. The diagnosis of OSA was defined as an oxygen desaturation index of at least 5, was established with the use of polysomnographic examination at hospital. Patients were excluded from the study if they had head injury, brain tumour, headache history and hearing loss. Patients who had vertigo were labeled as Vertigo group. In the other hand, patients who had no dizziness were labeled as control group. 58 patients were in the Vertigo group, and 113 were in the control group. After PSG examination, 58 patients who had vertigo, were diagnosed OSA (29 males, average age = 57.07 years old, BMI = 26.64, RDI = 24.69, ESS = 8.65), and 24 patients of them (41.3%) were REM-related OSA. Meanwhile, in the control group, 113 patients had OSA (92male, average age = 49.66 years old, BMI = 26.06, RDI = 35.19, ESS = 11.43), and 18 patients of them (15.9%) were REM-related OSA (Table 1). Therefore, patient who had vertigo, would have higher proportion of REM OSA (P<0.001). The vertigo patients have a higher rate of REM-related OSA, and the acceptance rate to CPAP use is low. Further research is needed to explore novel therapeutic approaches, or combination of currently available non-CPAP therapies, in patients with REM OSA.

CPAP treatment in REM-related obstructive sleep apnea: a distinct clinical phenotype of sleep disordered breathing.

REM-related obstructive sleep apnea (REM-OSA), as defined using revised apnea-hypopnea index (AHI) criteria, might represent a specific OSA phenotype. However, there is a lack of data on outcomes of treatment in this population. This study evaluated the effects of CPAP treatment over 12months on clinical outcomes for patients with the polysomnography phenotype of REM-OSA. We conducted a prospective observational study with the following inclusion criteria: subjective sleepiness and diagnostic polysomnography demonstrating AHIREM≥15 events/h, AHINREM<5 events/h, and ≥30min of REM sleep. Clinical outcomes assessed included Epworth Sleepiness Scale (ESS), psychomotor vigilanc test reaction time (PVT-RT), and CPAP adherence at baseline, 1, 3, 6, and 12 months; Functional Outcomes of Sleep Questionnaire (FOSQ) and Depression Anxiety Stress Scales (DASS-21) at baseline, 1, 3 and 12 months. The reason is the first 3 outcomes (ESS, PVT, adherence) were assessed at baseline, 1, 3, 6, and 12 months, while the next 2 outcomes (FOSQ, DASS) were assessed at baseline, 1, 3, and 12 months. The edited version is not as clear in separating these outcomes into 2 groups; Functional Outcomes of Sleep Questionnaire (FOSQ); and Depression Anxiety Stress Scales (DASS-21) at baseline, 1, 3, and 12months. Linear mixed effects models were used to investigate the joint effects of time and average CPAP adherence on our outcomes of interest. Twenty participants completed a minimum of 1 month of CPAP treatment and were included for analysis. During the trial, 8 participants discontinued CPAP (4 before 3months, 1 before 6months, 3 before 12months), and 19 participants completed 12months of treatment. Baseline ESS was elevated at 12.6 units. Average CPAP usage for all 27 participants over 12months was 2.9 ±2.4h. There was a significant decrease in ESS and increase in FOSQ at all time points, and the decrease in ESS was only seen in the CPAP-adherent subgroup. Decreases in DASS-21 and PVT-RT were not sustained. CPAP treatment in sleepy patients with moderate to severe REM-OSA is associated with reduced sleepiness and improved quality of life. The trial was registered in the Australian New Zealand Clinical Trials Registry: ACTRN12620000576921, 18/05/2020 (retrospectively registered).

Characteristics of patients with rapid eye movement-related obstructive sleep apnea: a retrospective review of 52 patients at a tertiary care center

Background: The term “rapid eye movement (REM)-related obstructive sleep apnea (OSA)” is commonly used to describe sleep disordered breathing that occurs exclusively in REM sleep. The prevalence of REM-related OSA ranges from 10% to 36%. Despite the presence of reports describing the features of REM-related OSA, there is still much more to be known about it.Methods: In this study we did retrospective review of 734 patients who had a diagnostic sleep study in a sleep lab at a tertiary center between January 2014 and August 2016 were reviewed.Results: We found that hypertension was found in the charts of 50 patients, 36 of them were diagnosed with hypertension and on medical therapy (72%), 11 patients (out of 50) had diabetes (22%) and 9 (out of 49) had dyslipidemia. 2 patients (out of 49) had Ischemic heart disease (4%), 1 patient (out of 49) had stroke (2%) and 3 patients (out of 49) had arrhythmias (6%). 8 patients (out of 49) had thyroid disease (16%).Conclusions: In conclusion Most patients had mild REM related OSA and most did not have subjective EDS. Hypertension was the most common comorbidity among our patients.

Assessment of the Impact of Different Diagnostic Definitions on REM-related Obstructive Sleep Apnea: Board versus Restricted?

Assessment of the Impact of Different Diagnostic Definitions on REM-related Obstructive Sleep Apnea: Board versus Restricted?

Mild Obstructive Sleep Apnea Tends to Be Associated with Sleep State Misperception

Objective Sleep state misperception (SSM) is a disorder that is characterized by insomnia or excessive sleepiness without objective evidence of sleep disturbance. The cause of SSM has not yet been elucidated. This study aimed to explore sleep perception tendencies by comparing polysomnography (PSG) data and subjective sleep reports in patients with and without obstructive sleep apnea (OSA). Methods We retrospectively analyzed 638 participants with PSG results. We classified the participants into three groups based on their OSA severity (non-OSA, n=174; mild OSA, n=214; moderate OSA, n=250), and compared the PSG parameters and various sleep questionnaires among the groups using an analysis of variance. Additionally, we identified the rapid eye movement (REM)-related OSA and compared the variables between the REM-related OSA and non-REM-related OSA groups using independent t and chi-square tests. Results The participants with less severe OSA presented better quality and quantity of sleep in PSG (longer total sleep time, higher sleep efficiency, fewer arousals, and more deep sleep), but reported much worse sleep disturbances based on sleep questionnaires. Those with REM-related OSA showed a larger discrepancy between subjective and objective sleep. Conclusion This study found that individuals with milder OSA and REM-related OSA tended to present larger discrepancies in objective and subjective sleep states. Further research based on our preliminary findings is warranted to better recognize SSM and treat complicated sleep disorders. Keywords: Obstructive sleep apnea; Paradoxical insomnia; REM-related obstructive sleep apnea; Sleep misperception

The relationship of obstructive sleep apnea and cardiovascular diseases from the perspective of evidence-based medicine. Part 1

The results of prospective studies, meta-analyzes and systematic reviews on the associations of obstructive sleep apnea (OSA) with various cardiovascular diseases (CVD) were analyzed. Currently, the mechanisms related to high prevalence of breathing-related sleep disorders among population of economically developed countries are clear, and an increase in the number of OSA patients has been shown. The relationship between OSA and CVD has been widely confirmed in large cohort studies. The first review part discusses the relationship of hypertension (HTN) and various heart arrhythmias (atrial fibrillation (AF), bradyarrhythmias, premature ventricular contraction, sudden death during sleep) with breathing-related sleep disorders. These groups of cardiovascular disorders currently show the most proven relationship with sleep apnea. In addition to cross-sectional studies indicating the high prevalence of OSA in patients with HTN and AF, some observational studies indicate an increase in the number of patients with HTN and paroxysmal AF with history of untreated sleep apnea. An analysis of the current issues of OSA phenotypes (in particular, REM-related OSA in hypertensive patients) as the most unfavorable cardiovascular factors is carried out.

Insomnia as a Symptom of Rapid Eye Movement-Related Obstructive Sleep Apnea.

Rapid eye movement (REM)-related obstructive sleep apnea (OSA), a polysomnographic phenotype that affects 12–36% of OSA patients, is defined by apnea and hypopnea events that predominantly or exclusively occur during REM sleep. Recent studies indicated that REM-related OSA was associated with the development of nocturnal non-dipping of systolic and diastolic blood pressure, metabolic syndrome, diabetes, and depressive symptoms. However, to date, the association between REM-related OSA and insomnia still remains unclear. We investigated whether there was a difference between REM- and non-REM-related OSA in terms of insomnia-related sleep disturbance as measured by the Pittsburgh Sleep Quality Index (PSQI) in 1736 patients with OSA. REM-related OSA showed a significant association with increased PSQI in all adjusted models. In the subgroup analysis, the coefficients of all models were higher in female than in male patients with REM-related OSA. Insomnia should be considered an important complaint in patients with REM-related OSA, and its indicators, such as the PSQI, should be included in routine diagnostic testing.

0904 Rapid Eye Movement Related Obstructive Sleep Apnea In The Pediatric Population: Case Series And Considerations

Abstract Introduction Rapid Eye Movement (REM) related Obstructive Sleep Apnea (OSA) can impact sleep quality and result in negative clinical consequences. There are limited pediatric studies evaluating potential consequences, looking at optimal decision making, and discussing best treatment options. Aims: 1: Describe clinical impact and potential negative consequences; 2: Discuss treatment management of REM related OSA; 3: Evaluate clinical effectiveness of treatment. Methods Case series: Retrospective review of 22 pediatric patients with REM related OSA at a tertiary care center. Clinical analysis of implemented treatment modality vs. observation was reviewed. Symptomatic response to treatment modality vs. observation including alteration of quality of life was examined. Results REM related OSA lead to negative clinical daytime symptoms which warranted consideration and implementation of further treatment. Conclusion Treatment considerations for REM related OSA include tonsillectomy and adenoidectomy, positive airway pressure, medical management, and watchful waiting. Further research is necessary to increase knowledge of clinical impact of REM related OSA and treatment. Support N/A

0436 Deep Learning for Scoring Sleep Based on Signals Available in Home Sleep Apnea Test Studies: Cardiorespiratory Sleep Staging

Abstract Introduction Typically, neurological signals are not recorded in home sleep apnea testing (HSAT) and thus standard sleep scoring is not applicable. The respiratory event index is calculated using total recording time rather than total sleep time (TST) resulting in a risk of underestimating sleep apnea severity. The objective of the study was to evaluate if artificial intelligence approaches can provide sleep scoring based on cardiorespiratory signals (CReSS) with reasonable accuracy. Methods Supervised deep learning for scoring sleep was trained with 472 and tested in 116 polysomnographies (PSG), scored independently by two experts and by a consensus scorer. The resulting bidirectional long short-term memory recurrent neural network (RNN) was integrated in the Somnolyzer system and validated in 97 PSGs of patients with obstructive sleep apnea (OSA) which had been scored independently by four human experts. Cohen’s kappa agreement for four stages (W, L: N1+N2, D: N3, R) was determined as compared to a consensus scoring. Results Epoch-by-epoch comparison between CReSS autoscoring and manual consensus scoring resulted in Cohen’s kappa of 0.68 (W: 0.74, L: 0.63, D: 0.54, R: 0.79). The intra-class correlation coefficient (ICC) between TST derived from CReSS and from neurological scoring was 0.86 (95%-CI: 0.79-0.90), while the ICC between subjective TST from sleep questionnaire and the objective TST was only 0.65 (95%-CI: 0.45-0.77). REM-related OSA had a prevalence of 16% and was detected with an accuracy of 95%. Conclusion With a kappa of 0.68, the cardiorespiratory-based RNN classifier is far above previously published values and reflects a substantial agreement with the manual consensus scoring in patients with sleep-disordered breathing. Thus, applying CReSS allows a more accurate determination of the OSA-severity and even a detection of REM related OSA in HSAT studies. Support All authors are employees of Philips

0838 Sex Specific Changes in Sleep Macro-Structure With Obstructive Sleep Apnea in a Large Clinical Population of Older Adults

Abstract Introduction Sleep architecture is influenced by age and sex and is disrupted by obstructive sleep apnea (OSA) and periodic limb movements (PLM) of sleep. Although increasing OSA severity is thought to decrease both REM and slow wave sleep (SWS), it may do so in non-linear ways. Here, we aim to 1) compare sleep macrostructure between older men and women, 2) compare metrics of total and REM-specific OSA severity between older men and women, and 3) examine associations between metrics of OSA severity and REM sleep and SWS in a clinical sample. Methods Clinical in-lab diagnostic polysomnography (PSG) in adults ≥64 years of age from the greater New York area recorded between 2006- 2016 were collated including demographic and traditional sleep scoring metrics. Studies where TST &amp;lt; 4 hours were removed. Demographic, sleep macrostructure, OSA (AHI4% &amp; AHI3A criteria), pulse oximetry (SpO2) nadir and PLM measures were compared according to sex. Results PSGs from 1282 older adults (average age 70 years in both sexes, 41% female) were included in the analyses. Women had a significantly greater SWS% (14.5 vs 7.9, p&amp;lt;0.001) and less N1% (18.2 vs 24.4, p&amp;lt;0.001), without significant differences in TST, N2%, REM%, sleep efficiency or SpO2 nadir. Men had significantly higher all-sleep OSA (median AHI4% 8.8 vs 11.1, p=0.0004; median AHI3A 24.4 vs 27.9, p=0.003) and PLM’s (4.0 vs 7.6/hour, p=0.008) but women had significantly more OSA during REM sleep (median REM AHI4% 16.7 vs 14.0, p=0.01; median REM AHI3A 32.6 vs 27.4, p=0.0002). Inverse non-linear associations were observed between OSA severity and %SWS and %REM with a unique pattern for each sleep stage. The pattern between men and women within each stage appeared similar. Conclusion In this clinical sample of older adults, women exhibit a greater proportion of SWS and worse REM-related OSA then men. Increasing OSA severity is associated with non-linear reductions in %SWS and %REM, and we plan to further investigate these relationships and sexual dimorphism by using quantitative analysis of PSG signals for more precise measures of slow wave activity and breathing physiology than traditional sleep scoring metrics. Support R01AG056682

REM-related obstructive sleep apnea: when does it matter? Effect on motor memory consolidation versus emotional health.

The clinical importance of obstructive sleep apnea, which can be prevalent during rapid eye movement (REM) sleep, is unclear. The current study examines the effect of REM-related obstructive sleep apnea on motor memory consolidation as well as on mood states. We compared performance on the motor sequence task (MST), psychomotor vigilance test (PVT), Functional Outcomes of Sleep Questionnaire, and the Profile of Mood State (POMS) survey between 3 groups: healthy controls (n = 18), REM-exclusive OSA (n = 17), and patients with OSA with respiratory events throughout REM and non-rapid eye movement (NREM) sleep (n = 18). As expected, performance on the MST improved overnight in the healthy control group. An improvement which was similar in magnitude was also observed in the REM-exclusive OSA group whereas patients with similar OSA during REM and NREM sleep showed reduced overnight memory consolidation. Consistent with these results, we found a correlation between overnight MST improvement and the apnea hypopnea index during NREM sleep (P = .041), but not during REM sleep (P = .424). However, patients with REM-exclusive apnea demonstrated the most negative emotions based on scoring highest on the POMS survey (P = .019). Our results provide evidence that although apneas occurring only during REM sleep do not have an effect on the encoding and stabilization of motor sequence memories, they are deleterious for emotional health.