Religious Orders Research Articles

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disease and apolipoprotein E (APOE) genotypes (APOE2, APOE3, and APOE4) show different AD susceptibility. Previous studies indicated that individuals carrying the APOE2 allele reduce the risk of developing AD, which may be attributed to the potential neuroprotective role of APOE2. However, the mechanisms underlying the protective effects of APOE2 is still unclear.MethodsWe analyzed single-nucleus RNA sequencing and bulk RNA sequencing data of APOE2 and APOE3 carriers from the Religious Orders Study and Memory and Aging Project (ROSMAP) cohort. We validated the findings in SH-SY5Y cells and AD model mice by evaluating mitochondrial functions and cognitive behaviors respectively.ResultsThe pathway analysis of six major cell types revealed a strong association between APOE2 and cellular stress and energy metabolism, particularly in excitatory and inhibitory neurons, which was found to be more pronounced in the presence of beta-amyloid (Aβ). Moreover, APOE2 overexpression alleviates Aβ1-42-induced mitochondrial dysfunction and reduces the generation of reactive oxygen species in SH-SY5Y cells. These protective effects may be due to ApoE2 interacting with estrogen-related receptor alpha (ERRα). ERRα overexpression by plasmids or activation by agonist was also found to show similar mitochondrial protective effects in Aβ1-42-stimulated SH-SY5Y cells. Additionally, ERRα agonist treatment improve the cognitive performance of Aβ injected mice in both Y maze and novel object recognition tests. ERRα agonist treatment increased PSD95 expression in the cortex of agonist-treated-AD mice.ConclusionsAPOE2 appears to enhance neural mitochondrial function via the activation of ERRα signaling, which may be the protective effect of APOE2 to treat AD.

Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment.

At least one-third of the identified risk alleles from Genome-Wide Association Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport, or direct lipid binding. In fact, a common genetic variant (ε4) in a cholesterol and phospholipid transporter, Apolipoprotein E (APOEε4), is the primary genetic risk factor for late-onset AD. In addition to genetic variants, lipidomic studies have reported severe metabolic dysregulation in human autopsy brain tissue, cerebrospinal fluid, blood, and multiple mouse models of AD. We aimed to identify an overarching metabolic pathway in lipid metabolism by integrating analyses of lipidomics and transcriptomics from the Religious Order Study and Rush Memory Aging Project (ROSMAP) using differential analysis and network correlation analysis. Coordinated differences in lipids were found to be dysregulated in association with both mild cognitive impairment (MCI) and APOEε4 carriers. Interestingly, these correlations were weakened when adjusting for education. Indeed, the cognitively non-impaired APOEε4 carriers have higher education levels in the ROSMAP cohort, suggesting that this lipid signature may be associated with a resilience phenotype. Network correlation analysis identified multiple differential lipids within a single module that are substrates and products in the Lands Cycle for acyl chain remodeling. In addition, our analyses identified multiple genes in the Lands Cycle acyl chain remodeling pathway, which were associated with cognitive decline independent of amyloid-β (Aβ) load and tau tangle pathologies. Our studies highlight the critical differences in acyl chain remodeling in brain tissue from APOEε4 carriers and individual non-carriers with MCI. A coordinated lipid profile shift in dorsolateral prefrontal cortex from both APOEε4 carriers and MCI suggests differences in lipid metabolism occur early in disease stage and highlights lipid homeostasis as a tractable target for early disease modifying intervention.

Trinitarian Theology, Neapolitan Painting: Paolo De Matteis and Francesco Solimena

Abstract In early eighteenth-century Naples, Paolo De Matteis created a series of frescoes featuring the Trinity in imitation of a mural at the Escorial by his former teacher, Luca Giordano. By showing the Trinity with its patrilinear procession from the Father to the Son, the younger artist could claim an artistic lineage in competition with Francesco Solimena. De Matteis’s and Solimena’s Trinitarian murals reveal theological disagreements between religious orders in Naples. An unknown drawing in the Seattle Art Museum can be associated with De Matteis’s group of works.

ASPECTS OF NEW HIGH GERMAN LANGUAGE FORMATION OF THE 18th CENTURY (Gabriel Bodenehr’s Plan of Kamianets-Podilskyi, 1726)

The research examines the peculiarities of the formation of the German language in the New High German period using the example of the plan of the Ukrainian city in Podil – Kamianets-Podilskyi. This document was created in 1726 in the city of Augsburg (northern Germany) by the famous German engraver and cartographer Gabriel Bodenehr. The work aims to study the process of the formation of the New High German language at its early stage in historical, cultural, regional and linguistic contexts; to illustrate them on the example of the text of the explication of the city plan. The task of this research is to characterize the peculiarities of the process of normalization of the German language in the New High German period; to determine changes in language levels on the example of the German text of the explanation of the city plan of Kamianets-Podilskyi. To achieve the specified goal and solve the tasks, the following research methods were used: descriptive, comparative-historical, biographical, comparative, and linguistic. As a result of the research, it was found that the text of the plan, although it was written in the New High German period, which is characterized by the desire to create a language standard and the departure from regional dialects, still retains its regional flavour and reference to the written norm of the Viennese chancellery. The conducted research proved that the orthographic and phonetic levels were most affected by the region, where there are significant variations of graphemes in marking the length and shortness of the sound, qualitative changes in vowel sounds, orthographic and graphic features of consonant markings, gravitation to the norms of the Viennese chancellery, as well as a gradual rejection of orthographic norms of the Middle High German period. Certain changes at the morphological level were found in the explication text, which testifies to the formation and consolidation of some grammatical categories (tense forms of verbs, use of passive constructions, declension of nouns and adjectives). The information focus of the text determines its lexical content, which can be seen in the author’s extensive use of anthroponyms (names of architectural and church buildings) and toponyms. The historical and cultural context of the development of the city of Kamianets-Podilskyi is reflected in the author’s use of proper names (names of historical figures, religious orders, political and military groups) and a significant number of borrowings from French, Turkish/Arabic, Latin, and Italian languages. It has been established that the syntactic level is the most normalized and closest to the modern German language. Therefore, the conducted linguistic analysis of the text of the city plan testified that in the first half of the 18th century, there was no complete unification of the written norm of the German literary language. However, separate attempts were made to standardize it. Among the promising research areas, it is worth conducting a comparative analysis of other city plans of this period in order to identify common features in the development of the German language.

MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults.

Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkers may outperform one another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortical thickness signature of AD (AD-CT) and plasma p-tau217, for predicting Alzheimer dementia. Data came from community-dwelling older participants of the Religious Orders Study or the Rush Memory and Aging Project. AD-CT was obtained from 3T MRI scans using a magnetization-prepared rapid acquisition gradient echo sequence and by averaging thickness from previously identified cortical regions implicated in AD. Plasma p-tau217 was quantified using an immunoassay developed by Lilly Research Laboratories on the MSD platform. Both MRI scans and blood specimens were collected at the same visits, and subsequent diagnoses of Alzheimer dementia were determined through annual detailed clinical evaluations. Cox proportional hazards models examined the associations of the 2 biomarkers with incident Alzheimer dementia, and prediction accuracy was assessed using c-statistics. A total of 198 older adults, on average 84 years of age, were included. Over a mean follow-up of 4 years, 60 (30%) individuals developed Alzheimer dementia. AD-CT (hazard ratio: 1.71, 95% CI 1.26-2.31) and separately plasma p-tau217 (hazard ratio: 2.57, 95% CI 1.83-3.61) were associated with incident Alzheimer dementia. The c-statistic for prediction accuracy was consistently higher for plasma p-tau217 (between 0.74 and 0.81) than AD-CT (between 0.70 and 0.75) across a range of time horizons. Furthermore, with both biomarkers included in the same model, there was only modest improvement in the c-statistic due to AD-CT. Plasma p-tau217 outperforms an imaging-based cortical thickness signature of AD in predicting future Alzheimer dementia diagnosis. Furthermore, the AD cortical thickness signature adds little to the prediction accuracy above and beyond plasma p-tau217.

Hypocrisy, ‘Prudence’, ‘Conscience’ in Administration: The Congregation of Bishops and Regulars in Seventeenth-Century Italy

The article argues that the post-Tridentine papacy was more focused on maintaining its own centrality than on implementing the reforms established by the Council of Trent. It shows that the Roman Curia often undermined its own bishops and interfered with their efforts to reform their dioceses. This practice – which might be perceived as hypocritical by us and was viewed as such by some contemporary commentators – was seen as justified by the baroque political virtue of ‘prudence’, and the idea of bishops being the conscience keepers of their dioceses. The article, in pondering the theme of hypocrisy, explores the work of the Sacred Congregation of Bishops and Regulars, which was responsible for overseeing the episcopate and religious orders. It uses previously unnoticed sources from the Bodleian Library in Oxford to show how the Congregation operated and how it perceived its role in defending the rights of the church and its clergy.

Religious sects as a threat to social security in the Republic of Armenia

The article presents the contemporary religious situation in Armenia. It explains why the Armenian society perceives members of minority churches and various religious associations as enemies of their country and national unity. It contributes to research on internal security, especially on social and cultural security. The internal security of the Republic of Armenia rests on two central pillars: national culture and related Christian religion, tradition and spiritual inheritance – all of which are equated with the Holy Armenian Apostolic Church (AAC). Therefore, AAC is the primary entity fighting cultural threats and opposing secularisation. The text will show what threats to the Republic of Armenia are posed by the quick growth of religious “sects”. One thing that should be clarified at the very beginning is that AAC uses the term “sect” with reference to other churches and religious associations. Particular emphasis will be placed on investigating the relationships between religious “sects” and the world of politics and business. The author will also outline the involvement of religious “sects” in the political events in Armenia and attempt to present their perception by the society and state authorities. The author wants to demonstrate how religious “sects” and AAC – which fights against them using nationalistic slogans – may contribute to social unrest. Although the Armenian Apostolic Church exposes the problem caused by the presence of religious sects and the threat they pose to Armenian culture and nation, the author was unable to find a sufficient number of respondents to conduct a questionnaire survey on the presence of religious sects in the life of the Armenian society. Usually, respondents claim that these are marginal groups that we should not worry about. That is why the activity of religious “sects” was analysed based on the materials provided by the Armenian media (including independent media) and the information service of the Armenian Apostolic Church.

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele of the protective variant (rs1582763) is associated with higher sTREM2 and lower AD risk while the minor allele of (rs6591561) relates to lower sTREM2 and higher AD risk. Our group previously found that higher sTREM2 relates to higher Aβ40, worse blood–brain barrier (BBB) integrity (measured with the CSF/plasma albumin ratio), and higher CSF tau, suggesting strong associations with amyloid abundance and both BBB and neurodegeneration complicate interpretation. We expand on this work by leveraging these common variants as genetic tools to tune the interpretation of high CSF sTREM2, and by exploring the potential modifying role of these variants on the well-established associations between CSF sTREM2 as well as TREM2 transcript levels in the brain with AD neuropathology. Biomarker analyses leveraged data from the Vanderbilt Memory & Aging Project (n = 127, age = 72 ± 6.43) and were replicated in the Alzheimer’s Disease Neuroimaging Initiative (n = 399, age = 73 ± 7.39). Autopsy analyses were performed leveraging data from the Religious Orders Study and Rush Memory and Aging Project (n = 577, age = 89 ± 6.46). We found that the protective variant rs1582763 attenuated the association between CSF sTREM2 and Aβ40 (β = -0.44, p-value = 0.017) and replicated this interaction in ADNI (β = -0.27, p = 0.017). We did not observe this same interaction effect between TREM2 mRNA levels and Aβ peptides in brain (Aβ total β = -0.14, p = 0.629; Aβ1-38, β = 0.11, p = 0.200). In contrast to the effects on Aβ, the minor allele of this same variant seemed to enhance the association with blood–brain barrier dysfunction (β = 7.0e-4, p = 0.009), suggesting that elevated sTREM2 may carry a much different interpretation in carriers vs. non-carriers of this allele. When evaluating the risk variant (rs6591561) across datasets, we did not observe a statistically significant interaction against any outcome in VMAP and observed opposing directions of associations in ADNI and ROS/MAP on Aβ levels. Together, our results suggest that the protective effect of rs1582763 may act by decoupling the associations between sTREM2 and amyloid abundance, providing important mechanistic insight into sTREM2 changes and highlighting the need to incorporate genetic context into the analysis of sTREM2 levels, particularly if leveraged as a clinical biomarker of disease in the future.

Association of Alzheimer's Disease and Other Neuropathologies With Functional Disability in Persons With and Without Dementia.

Dementia results from multiple neuropathologies causing cognitive impairment sufficiently severe to affect functional status. However, these pathologies and functional impairment are common in persons without dementia. We examined the association of Alzheimer's disease (AD) and multiple other neuropathologies with instrumental and basic activities of daily living in persons with and without dementia. Participants were 1509 deceased from the Religious Orders Study or Rush Memory and Aging Project. Pathologic AD and 3 other AD indices were examined, in addition to 4 non-AD neurodegenerative pathologies: cerebral amyloid angiopathy (CAA), hippocampal sclerosis, TDP-43, and Lewy bodies, and 4 cerebrovascular pathologies: gross- and microinfarctions, athero- and arteriolosclerosis. Functional assessment included Lawton and Katz Index Instrumental and Basic Activities of Daily Living (IADL and BADL). Ordinal regression models adjusted for age, sex, and education were used to examine the association of neuropathologies with IADL and BADL. Alzheimer's disease and the other neuropathologies were associated with impaired IADL (all ps < .001) and with impaired BADL (ps < .01), except for atherosclerosis and CAA, which were not associated with BADL. The effects of most neuropathologies were largely affected by dementia. However, small effects on IADL remained for PHF-tau tangles after adjusting models for dementia. Direct effects of gross infarcts on IADL and BADL and of microinfarcts on BADL remained unchanged after adjusting the models for dementia. Alzheimer's disease and all other neuropathologies are strongly associated with functional disability. The association of most neuropathologies with disability was eliminated or attenuated by dementia, except for gross infarcts and microinfarcts.

Unravelling social status in the first medieval military order of the Iberian Peninsula using isotope analysis

Medieval Iberia witnessed the complex negotiation of religious, social, and economic identities, including the formation of religious orders that played a major role in border disputes and conflicts. While archival records provide insights into the compositions of these orders, there have been few direct dietary or osteoarchaeological studies to date. Here, we analysed 25 individuals discovered at the Zorita de los Canes Castle church cemetery, Guadalajara, Spain, where members of one of the first religious orders, the Order of Calatrava knights, were buried between the 12th to 15th centuries CE. Stable carbon (δ13C) and nitrogen (δ15N) isotope analyses of bone collagen reveal dietary patterns typical of the Medieval social elite, with the Bayesian R model, ‘Simmr’ suggesting a diet rich in poultry and marine fish in this inland population. Social comparisons and statistical analyses further support the idea that the order predominantly comprised the lower nobility and urban elite in agreement with historical sources. Our study suggests that while the cemetery primarily served the order's elite, the presence of individuals with diverse dietary patterns may indicate complexities of temporal use or wider social interaction of the medieval military order.

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.

Cellular senescence is a hallmark of aging and has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation drives cellular senescence; however, the underlying mechanisms are unclear. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis. ABCA1 expression and its trafficking is afiltered in APOE4 and AD cellular and mouse models. However, whether ABCA1 trafficking is involved in cellular senescence in APOE4 and AD remains unknown. We examined the association between cellular senescence and ABCA1 expression in human postmortem brain samples using transcriptomic, histological, and biochemical analyses. An unbiased proteomic screening was performed to identify targets that mediate cellular ABCA1 trafficking. APOE4-TR mice, immortalized, primary and induced pluripotent stem cell (iPSC) models were used to examine the cholesterol-ABCA1-senescence pathways. Bulk and single nuclei transcriptomic profiling of the human dorsolateral prefrontal cortex from the Religious Order Study/Memory Aging Project (ROSMAP) revealed upregulation of cellular senescence transcriptome signatures in AD, which was strongly correlated with ABCA1 expression. Immunofluorescence and immunoblotting analyses confirmed increased ABCA1 expression in AD brain tissues, which was associated with lipofuscin-stained lipids and mTOR phosphorylation. Using discovery proteomics, caveolin-1, a sensor of cellular cholesterol accumulation, was identified to promote ABCA1 endolysosomal trafficking. Greater caveolin-1 expression was found in both APOE4-TR mouse models and AD human brains. Cholesterol induced mTORC1 activation was regulated by ABCA1 expression or its lysosomal trapping. Reducing cholesterol by cyclodextrin in APOE4-TR mice reduced ABCA1 lysosome trapping and increased ABCA1 recycling to efflux cholesterol to HDL particles, reducing mTORC1 activation and senescence-associated neuroinflammation. In human iPSC-derived astrocytes, the reduction of cholesterol by cyclodextrin attenuated inflammatory responses. Cholesterol accumulation in APOE4 and AD induced caveolin-1 expression, which traps ABCA1 in lysosomes to activate mTORC1 pathways and induce cellular senescence. This study provided novel insights into how cholesterol accumulation in APOE4 and AD accelerates senescence.

Historical stages of the pastoral care of the Minorites in Spišský Štvrtok and Levoča

The topic of the study is the activity of the Order of Franciscan Friars Minor – the Minorites in Levoča and Spišský Štvrtok. In the introduction, the author gives a historical overview of the establishment of this religious order and then continues with the characteristics of the period of the Franciscans’ arrival in Spiš and their settlement in Levoča and Spišský Štvrtok. The study recalls the importance of the monasteries built by the Minorites in both localities. A period of promising spiritual and cultural development of the order was violently interrupted by the Night of the Barbarians, the closure of the monasteries and the deportation of the Franciscans. After 1989, the activity of the Franciscan Friars Minor in Slovakia and Spiš was renewed.

Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer’s disease

The metabolic implications in Alzheimer’s disease (AD) remain poorly understood. Here, we conducted a metabolomics study on a moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile acids, branch-chain amino acids (BCAAs), and glutamate-related features exhibited strong correlations with cognitive impairment, clinical stage, and brain amyloid-β deposition (n = 421). These features demonstrated synergistic performances across clinical stages and subpopulations and enhanced the differentiation of AD stages beyond demographics and Apolipoprotein E ε4 allele (APOE-ε4). We validated their performances in eight data sets (total n = 7685) obtained from Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Religious Orders Study and Memory and Aging Project (ROSMAP). Importantly, identified features are linked to blood ammonia homeostasis. We further confirmed the elevated ammonia level through AD development (n = 1060). Our findings highlight AD as a metabolic disease and emphasize the metabolite-mediated ammonia disturbance in AD and its potential as a signature and therapeutic target for AD.

Select document: The last will and testament of Diarmaid Ó Conchobhair, prior of Cluain Tuaiscirt na Sionna

AbstractIt was not common for members of religious orders in the late middle ages to make a last will and testament because profession as a regular removed their testamentary capacity. This article prints the Latin text of the testament of Brother Diarmaid Ó Conchobhair, prior of Cloontuskert na Sinna, O.S.A., County Roscommon, drawn up in 1462 and proved a year later in London, along with a translation. It also offers a discussion of the testament, including Ó Conchobhair's stated intention of going on pilgrimage to Rome, in the light of other evidence relating to both its testator and to the monastic orders in general in late medieval Ireland and England.

The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study

Many studies have reported that impaired gait precedes cognitive impairment in older people. We aimed to characterise the time course of cognitive and motor decline in older individuals and the association of these declines with the pathologies of Alzheimer's disease and related dementias. This multicohort study used data from three community-based cohort studies (Religious Orders Study, Rush Memory and Aging Project, and Minority Aging Research Study, all in the USA). The inclusion criteria for all three cohorts were no clinical dementia at the time of enrolment and consent to annual clinical assessments. Eligible participants consented to post-mortem brain donation and had post-mortem pathological assessments and three or more repeated annual measures of cognition and motor functions. Clinical and post-mortem data were analysed using functional mixed-effects models. Global cognition was based on 19 neuropsychological tests, a hand strength score was based on grip and pinch strength, and a gait score was based on the number of steps and time to walk 8 feet and turn 360°. Brain pathologies of Alzheimer's disease and related dementias were assessed at autopsy. From 1994 to 2022, there were 1570 eligible cohort participants aged 65 years or older, 1303 of whom had cognitive and motor measurements and were included in the analysis. Mean age at death was 90·3 years (SD 6·3), 905 (69%) participants were female, and 398 (31%) were male. Median follow-up time was 9 years (IQR 5-11). On average, cognition was stable from 25 to 15 years before death, when cognition began to decline. By contrast, gait function and hand strength declined during the entire study. The combinations of pathologies of Alzheimer's disease and related dementias associated with cognitive and motor decline and their onsets of associations varied; only tau tangles, Parkinson's disease pathology, and macroinfarcts were associated with decline of all three phenotypes. Tau tangles were significantly associated with cognitive decline, gait function decline, and hand function decline (p<0·0001 for each); however, the association with cognitive decline persisted for more than 11 years before death, but the association with hand strength only began 3·57 years before death and the association with gait began 3·49 years before death. By contrast, the association of macroinfarcts with declining gait function began 9·25 years before death (p<0·0001) compared with 6·65 years before death (p=0·0005) for cognitive decline and 2·66 years before death (p=0·024) for decline in hand strength. Our findings suggest that average motor decline in older adults precedes cognitive decline. Macroinfarcts but not tau tangles are associated with declining gait function that precedes cognitive decline. This suggests the need for further studies to test if gait impairment is a clinical proxy for preclinical vascular cognitive impairment. National Institutes of Health.

Inclusivism and exclusivism: Responses of prospective Islamic religious teachers towards Islamic sects

This article employs the notions of exclusivism and inclusivism to categorise the responses of prospective Islamic religion teachers towards various Islamic religious sects. Despite the prevalent criticism surrounding the perceived oversimplification and a lack of insight provided by the two typologies, we have found them to be valuable tools for elucidating the phenomena under investigation. Quantitative data were collected from 154 respondents using questionnaires containing multiple-choice questions. Data frequency, cross-tabulation and gamma values are statistical techniques employed to analyse and characterise data and ascertain the nature of their associations or dependencies. This study provides evidence indicating that a significant proportion of prospective Islamic religious teachers had a worldview characterised by exclusivity. Their exclusivist stance is seen in their acknowledgment of sects that deviate from their own, such as Wahhabism, Shia, and those engaging in non-scriptural forms of worship. Some individuals agree with the designation of heretical being attributed to those who adhere to distinct religious worship customs. Moreover, these individuals perceive contentious theological assertions, such as those made by Sheikh Panji Gumilang, as warped, misguided and beyond redemption.Contribution: This study implies the need to review and reconstruct higher education curricula to prepare prospective Islamic religion teachers who are moderate, tolerant, inclusive, and uphold human rights.

Evaluation of the historical reconstruction seen in the short story “Akhenaten, Aten and Religion”

The reconstruction of events that happened in the past can be quite a difficult task, especially when there are lots of factors relating to a certain section in history that cannot be controlled at all. For example, archaeological evidence doesn’t have one specific way of interpretation or simply blanks in history. Historical reconstruction can get even more complicated when historical accounts cannot be validated. These can be misleading to those who read history without the evaluation of sources or without researching archaeological evidence that potentially could disprove certain claims. A good example of this is Akhenaten, a unique figure in Egyptian history. Akhenaten, originally called Amenhotep IV, succeeded his father, Amenhotep III, as the tenth pharaoh of the 18th dynasty (Dorman, 2018). He is noted for changing the religion, art, and social structure of Egypt dramatically and founding “Atenism,” a completely new kind of religion that focused on the worship of one single god——Aten, characterized as a solar disc, a creator of lives and the chief god of the universe. Due to the peculiarity of the change and the elimination of elements of Egypt’s traditional social and religious order, after his reign, priests and succeeding rulers restored the traditions, destroying his religious architecture and gradually erasing the heretic king from history (Kemp, 2014). Based on how his successors described him, it can be seen that in later times, he was portrayed as a tyrant or a villainous character. However, modern historiography re-evaluates this claim, leading to a debate about the nature of Akhenaten’s new religion and his reign. This essay presents the basic facts of the period and evaluates the reconstruction of Akhenaten’s reign in the form of a short story, “Akhenaten, Aten and Religion,” and uses archaeological evidence.

Encounters with Care in a Scottish Residential School in the 1980s

The meaning of care in residential child care is under-developed. It can often be represented through its absence, seen as offering at best basic physical tending but lacking emotional connection or warmth. At worst, residential care settings said to be institutionally abusive can be characterised as being antithetical to what we might imagine care should be. Residential schools and especially those run by religious orders attract particular opprobrium in this regard. In this article, I adopt a broadly autoethnographic approach to reflect on how boys (now men in their late 40s and early 50s) brought up in the 1980s in a Scottish residential school recall being cared for. The article uses Axel Honneth’s theory of recognition and its three pillars of love, rights and solidarity to group themes from how former pupils speak about their experiences of care. These accounts challenge the received narrative of such settings failing to offer care. The discussion reflects some ideas around care and about how we understand public care historically.

Canon Law Aspects of the Office of Provincial Superior in a Religious Institute: A Look at the Law of the Order of Preachers

The study presents the office of provincial superior, starting with ordinaries and major superiors of religious orders. The office of prior provincial is characterised here on the basis of the law of the Order of Preachers (Dominicans). The following topics are covered: the relationship between the prior provincial and the ordinary of the place, authority in the Dominican Order, the basic powers of the prior provincial, requirements for a prior provincial candidate, and the functioning of the provincial during the provincial chapter.

The realization of the concept of the features of the historical novel by Walter Scott on the example of Barry Unsworth's novel "Moralite"

The article examines the features of the concept of the historical novel by Walter Scott on the example of Barry Unsworth's novel "Morality Play". The purpose of this article is to identify the features and principles of the historical method. The great merit of the outstanding Scottish writer Walter Scott (1771-1832) is that he introduced the principle of historicism into literature and wrote a number of brilliant historical novels. In them, readers see a picture of the struggle of contradictory and complex interests of various social groups, parties, and religious sects. His historical novels provided a better understanding of contemporary issues. He combined historical truth with fiction, explaining the validity of such a connection by saying that “the most important human passions in all their manifestations, as well as the sources that feed them, are common to all classes, states, countries and epochs; hence it invariably follows that although this state of society affects opinions, way of thinking and the actions of people, these latter are extremely similar in their very essence. Walter Scott was the founder of the historical novel in its modern sense. In the XIX century, he developed the principles of the historical method, which made it possible to create fascinating novels, freed from excessive archaization of language and at the same time fully conveying the originality and recognizable imprint of the described epoch. In the 19th century, along with the tradition dating back to Walter Scott, another form of aesthetic insight into the past also asserted itself. Real historical characters in such works are optional, although their presence is not excluded. The "hero" for the writer is not a historical event, but an "epoch". The author of such a work creates his own self-sufficient world, achieves credibility not by more or less accurately following historical material, but by the reality of the psychological experience of the characters, the reality (often illusory) of everyday life. The novel "Morality Play" is a historical detective novel by British writer Barry Unsworth, was published in 1995, and was first published in Russian in 2005. The novel is an example of a fruitful combination of two updated genres: new historical fiction and metaphysical detective.