This paper explores the religious projection and ethical appeal in the art and literature of Leda and the Swan created from ancient times to the contemporary era, so as to make a comparative review and reading on it, providing religious reflection and ethical enlightenment to today’s society. From ancient Greek vase paintings to contemporary English poems, the investigation shows that the story of Leda and the Swan has been continuously rewritten and revalued by history, religion and social ethics. The interaction between Leda and the swan goes from divinity to humanity, increasingly out of the cage of eroticism, symbolizing the process of transforming into a secularized life. Besides, Leda, as a representative victim of traditional patriarchy and religious persecution, goes from bondage to liberation, signaling the awakening of feminine consciousness and the gradual collapse of patriarchy; while the swan, an incarnation of power and desire under patriarchy, becomes an object of condemnation. However, as for who is the victim and who should be condemned, there are different religious and ethical standards in different historical periods, which reflects the development and evolution of religious rules and ethical orders in the historical process. By highlighting the Trojan War or woman’s sufferings, Leda and the Swan, in fact, reveals that the tragedy results from the uncontrollable animal factor and free will, and that women should face their ethical or religious identities to make correct choices.