Religious themes commonly feature in religious (OCD) patients. Many investigators believed that religious intervention could improve symptom of religious patients. The aim of this study was evaluate efficacy of Religious Cognitive- Behavior therapy (RCBT) on religious oriented Obsessive-Compulsive disorder. With randomized control clinical trial. This study conducted on 90 Religious OCD outpatients according to DSM IV, and divided into two groups, intervention (45) and control (45) groups with randomly. Intervention consisted of 10 weekly RCBT 90minutes session. Used Y-BOCS scale before and after treatment, and data analyzed by MANCOVA repeated measure test using SPSS ver.15. The result showed significant difference in Yale Brown scores after intervention in intervention groups (p=0.001).). Comparison of obsession and compulsion subscale of Yale Brown scale showed decreasing trend in both of obsession and compulsion between 2 groups. At the end added Religious component in CBT can help religious OCD patients.