The human history has recorded that in every 100 years a new pandemic will erupt to rocked control the human race from over population, changing the courses of history and signaling the end of entire civilization. Today the world is at halt and its economic, socio-cultural, religious, political, scientific and technological myth is degenerating amidst the advent of a novel pandemic (COVID-19). This study therefore, investigated the effect of COVID-19 in terms of economic, socio-cultural, educational and religious factors which are best described using students, private sectors, public servants, religious bodies and farmers as sectoral factors. The paper also addressed geopolitical regional zones differences in the effect of COVID-19 in Nigeria using schedules as a model for data collections. Generated data were analyzed using percentages, Two-way ANOVA and Co-Variance (ANOCOVA) to test for significant differences amidst the effects of COVID-19 among domain, sectors and geopolitical regions. Findings from the study show that 96% student’s educational process was negatively affected and about 94% economic values of privately owned business were grossly affected; 53% socio-cultural activities brought down because of the stay-at-home order; 58% religious activities (worship centre) were affected on the approval of only 20 members per 2 meters distancing in a service. More so, farmers experiences 58% economic loss underscored with an endemic increase in the price of major food items. The interactions term between COVID-19, domain and sector is not significant as it was felt equally on Domain and on sectoral factors. On the other hand, the effect of COVID-19 is felt differently among geopolitical regions in Nigeria owing to socio-cultural, economic, political and population difference. The paper therefore, recommended for the formulations and implementations of workable health care, social and educational welfare policies that respond and recover quickly to related disease; while relying more on domesticated products and byproducts.
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