The high theoretical energy density of Li-S batteries makes them a viable option for energy storage systems in the near future. Considering the challenges associated with sulfur's dielectric properties and the synthesis of soluble polysulfides during Li-S battery cycling, the exceptional ability of MXene materials to overcome these challenges has led to a recent surge in the usage of these materials as anodes in Li-S batteries. The methods for enhancing anode performance in Li-S batteries via the use of MXene interfaces are thoroughly investigated in this study. This study covers a wide range of techniques such as surface functionalization, heteroatom doping, and composite structure design for enhancing MXene interfaces. Examining challenges and potential downsides of MXene-based anodes offers a thorough overview of the current state of the field. This review encompasses recent findings and provides a thorough analysis of advantages and disadvantages of adding MXene interfaces to improve anode performance to assist researchers and practitioners working in this field. This review contributes significantly to ongoing efforts for the development of reliable and effective energy storage solutions for the future.