In order to improve the localization level of nuclear power and solve the “neck” problem of nuclear pressure reducing valve in CAP1400 project, the design reliability analysis and quality control requirements of domestic prototype of nuclear pressure reducing valve was studied. Through the analysis and application of the technical requirements of the pressure reducing valve, the control was strengthened from the reliability requirements of seismic analysis, identification test and quality control points, which provided a strong technical support for the localization of nuclear grade pressure reducing valve. The seismic analysis required that the stress, resonance frequency and deformation analysis on the dangerous section of the main parts of nuclear pressure reducing valve met the requirements of regulations and standards. The reliability control was carried out from three aspects: the selection of test medium, the stability control of pressure behind the valve and the requirements of failure operation performance. Quality point control taked quality control measures from three aspects: tooling design, standard application and test bench management. All measurements ensured that the design quality of nuclear pressure reducing valve meets the requirements. The successful development of the domestic prototype of nuclear grade pressure reducing valve shows the effectiveness of the design reliability analysis and quality control method, which provides a reference for the localization of equipment in the future.