To restore oral function after tumor excision, practitioners must undertake the enormous challenge of restoring hemimandibulectomy deficits. Depending on the type and extent of mandibular reconstruction (Cantor-Curtis classification), there are many prosthetic treatment options available for the rehabilitation of acquired hemimandibulectomy abnormalities. The objective of this systematic study is to evaluate the range of prosthodontic rehabilitation techniques in relation to the kind of repair and severity of mandibular surgical abnormalities. The databases incorporated for literature search were Google Scholar and Medline (PubMed). Relevant search terms for hemimandibulectomy and reconstruction with prosthetic rehabilitation were used. Two reviewers independently assessed the articles using eligibility criteria; published case reports and case series in the English language and depicting prosthodontic treatment modality of patients greater than 13 years were included. A total of 212 records were identified from the database search of which 29 duplicates were removed.The remaining articles were assessed for eligibility, and 50 articles (comprising 50 cases) were finally included in the study. This review identified a number of prosthetic options, including some novel prosthetic techniques, guiding flange, twin occlusion, palatal ramp, conventional to hybrid partial and complete dentures, and implant-supported prosthesis.The prosthetic options covered in this review included implant-supported prosthesis, guide flange, dual occlusion, palatal ramp, conventional, hybrid, and full dentures, as well as a few cutting-edge prosthetic techniques.As they plan and manage sequential therapy for hemimandibulectomy cases in their daily practice, practitioners and prosthodontists will find this helpful.