Relevant Publications Research Articles

P198 Systematic review to highlight practices and programmes for transition for adolescents with Inflammatory bowel disease

Abstract Background Adolescents with inflammatory bowel disease (IBD) will eventually transition from the family-centric paediatric healthcare team to the adult service. This process happens at an appropriate age or level of development and depends on a number of factors such as transition readiness, disease specific factors, and local policies and practice. This transition period is challenging for patients, families and healthcare providers. The use of structured transition programmes is increasingly incorporated into standards of care, yet the optimal format is not yet fully delineated, and practices vary considerably. The aim of this study was to carry out a systematic review of structured transition programmes and their components to assess impact on disease-specific and transition-related outcomes. Methods A literature review was carried out in four main databases (PubMed, CINAHL, CENTRAL, EMBASE) and relevant publications from the year range 1970-2023 reviewed. Inclusion criteria: reporting on adolescent IBD patients and investigating structured transition programmes/interventions. Exclusion criteria: not reporting outcomes relating to transition readiness/skills or disease related outcomes. Two investigators reviewed the articles, extracted data, and two assessed bias. Results There were 3432 articles identified from initial searches, and 38 included in the final review. Twenty-six studies reported the use of structured transition programmes, and 12 investigated discrete interventions. The key outcomes studies included knowledge, self-efficacy, adherence, clinic attendance and transition readiness. These outcomes consistently improved with the use of structured transition programmes. Those adolescents with IBD transitioning with no structured programme experienced a 3.5-fold increase in IBD related surgical rates, and 2-fold increase in hospital admission rates. Structured transition programmes were shown to significantly improve transition readiness assessment scores. Transitional care programmes consistently improved the following outcomes; relapse/admission rates, corticosteroid use, quality of life, and surgery. The bias assessment showed between-study heterogeneity, low quality of evidence, and high risk of bias. Conclusion Transition outcomes for adolescents with IBD were consistently improved with the use of structured transition programmes. This literature review highlights the considerable variation in delivery of transition care, and the need for optimization of strategies. There is no current standardized model for adolescent IBD patients in Australasia, and this review will guide development of regional IBD transitional care consensus statements.

Negative effects in randomized controlled trials of psychotherapies and psychological interventions: A systematic review

Background: Psychotherapy is a key evidence-based method for the treatment of mental disorders. However, little research has been published on the negative effects of psychotherapies. Aims: We examined this issue through a systematic literature review of previous systematic reviews on randomized controlled trials (RCTs). Methods: We focused on previous reviews and meta-analyses on 1) RCTs examining the effectiveness of psychotherapies and 2) previous reviews and meta-analyses specifically focusing on the negative effects of psychotherapy. We included publications published in PubMed and the Cochrane Databases from the year 2000 or later. Results: Of the 1,430 relevant publications, only a small proportion (30%) mentioned negative outcomes, mostly withdrawal. Only 57 of the extracted original studies monitored potential negative effects, and only three small-scale studies indicated negative effects. Conclusions: The systematic monitoring of negative effects in psychotherapy has not been given the same attention as has been given to the benefits of therapy.

Bibliometric Analysis of Augmented Reality Research in Medicine

This study aims to carry out a bibliometric analysis of the studies that have been carried out related to Augmented Reality (AR) in particular in the field of medicine. Augmented reality technology, which is becoming increasingly popular in the field of medicine, has the potential to improve medical diagnosis, treatment, and training. In this research, we perform bibliometric analysis of relevant scientific publications published in a particular period. Bibliometric analysis methodology gathers data on AR research in the field of medicine. This includes the title, author, journal where it was published, year of publication, and keyword used. The results of bibliometric analysis showed rapid progress in AR research in the field of medicine. In the last five years (2018-2023), as many as 250 publications were selected based on research criteria. This analysis reaches the conclusion that research on AR in the field of medicine is vital and increasingly recognized in the scientific community. The results of this analysis can help researchers and medical practitioners understand current trends with the use of AR in medical practice.

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies. To make a comprehensive analysis of recent studies concerning miRNAs in HCC. All relevant publications were retrieved from the Web of Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace software were used to visually analyze the distribution by time, countries, institutions, journals, and authors, as well as the keywords, burst keywords and thematic map. A total of 9426 publications on this topic were found worldwide. According to the keywords analysis, we found that the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the early years (2013-2017), "microRNA expression", "gene expression", "expression profile", "functional polymorphism", "circulating microRNA", "susceptibility" and "mir 21" started to attract attention. In the latest phase (2018-2022), the hot topics turned to "sorafenib resistance", "tumor microenvironment" and so on. This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis. The hotspots in this field focus on miRNAs expression level, effects, and mechanisms on the biological behavior of HCC. The frontiers turned to sorafenib resistance, tumor microenvironment and so on.

Quality of life and mental disorders in the post-COVID period (systematic review)

The 2019 novel coronavirus infection (COVID-19) pandemic has been a great burden for all of humanity. Soon after it began, researchers noticed that elimination of the virus from the body and recovery are not the end of the disease, since many patients did not return to their previous state of health, continued to complain of pathologies of various organs and systems, could not work, and some of them developed mental disorders.The aim of the review was to analyze and summarize published data on the quality of life and mental disorders in the post-COVID period. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, 7,374 scientific works were found, of which 176 English-language and 276 Russianlanguage relevant publications were selected for analysis. The review included 17 (including 2 Russian-language) articles relevant to the topic of this review. Complaints of decreased memory and attention, appearing no later than 6 months after recovery from COVID-19, were reported by 3.2–9.1% of patients. Asthenic symptoms during the first month after the elimination of the novel coronavirus infection occurred in 55–70% of patients, and six months later – in every fifth patient. At the same time, post-viral fatigue more often affected women discharged from respiratory hospitals and persons with chronic bronchopulmonary pathology. Quite often, those who recovered from COVID-19 experienced insomnia and emotional disturbances, the frequency of which also correlated with the female sex and the severe course of the disease, which required hospitalization in the intensive care unit (ICU). In the post-COVID period, the development of depressive symptoms is not excluded, but sufficient evidence for this has not been obtained. The quality of life in these patients decreased. After discharge from the hospital, some patients remained unable to work, and some began to experience difficulties with self-care. However, over time, there is a trend toward restoration of the quality of life, which is especially evident in young people. In patients who have been in the ICU for more than 7 days, the rehabilitation potential is much lower. Psychopathological symptoms contribute to a decrease in the quality of life along with physical factors (persistent dyspnea, decreased exercise tolerance).

Pathomorphological Characteristic of Pulmonary Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a polysystemic disease based on the formation of granulomas prone to degenerate into cysts in the lungs, abdominal and pelvic organs. Lung involvement in LAM is accompanied by respiratory dysfunction and can be fatal. WHO classifies this disease into a group of mesenchymal tumors and considers it as a low-grade destructive metastasizing neoplasm. LAM is a rare disease and earlier it was only detected in women, but nowadays cases of pulmonary LAM in men (include teenagers) have been described. The etiology of LAM and the inducing factors are still unknown. Objective – to collect and systematize data on pathomorphological characteristic of changes in lung tissue in LAM to evaluate the completeness and sufficiency of the available data. Material and methods. There were analyzed 912 articles and monographs (including duplicates) from PubMed, eLibrary, and Cyberleninka databases over a fifty-year period from 1973 to August of 2023, with an emphasis on more relevant publications and articles in highly rated scientific journals that include information on the review topic. Eventually 55 original sources were selected. Results. The article presents summary data on macroscopic and microscopic picture of pulmonary LAM, data on morphological and antigenic characterization of cells forming the basis of granulomas and their surroundings, the results of experiments demonstrating dynamics of pathological changes in LAM. Conclusion. Despite the relatively large amount of data about morphological characteristics that is enough for diagnosis, he main issue is still open: what is the origin of LAM cells? A systematic pathomorphology analyze can help us to find an answer for this question.

Understanding the drivers of rural household scaling up of integrated crop-livestock-forestry systems. A systematic review and bibliometric analysis

This literature review focuses on the drivers of Integrated Crop-Livestock-Forestry Systems (ICLFS) adoption by small farmers. It has enabled us to identify current trends and analyze the various drivers of adoption and knowledge gaps. According to the PRISMA literature review protocol, 1,352 scientific publications have been selected and analyzed after a Scopus database search. Data analysis was carried out in two steps. A systematic review was performed with the metadata of scientific publications using the Biblioshiny package of R 4.3.1 software. Then, the 42 most relevant publications were used for a brief narrative synthesis. The results showed that between 2003 and 2023, publications were made in 587 different sources. 73% of publications were scientific articles. 91% of publications were written by an average of 05 co-authors. The effectiveness of Integrated Crop-Livestock-Forestry Systems (ICLFS) practices, the production of organic matter and the effects on farmers’ livelihoods are the research topics considered. Five categories of factors were identified to facilitate the adoption of ICLFS by small farmers: (i) farmer profile, (ii) farm characteristics, (iii) economic factors, (iv) institutional factors and (v) biophysical factors. Policy orientations are the most decisive of all the factors identified, followed by the establishment of extension systems and social networks between farmers. This paper makes three main recommendations. Firstly, it recommends the implementation of collaborative research frameworks between West African researchers and those from East Africa, Asia and South America, who have more experience in this area. In addition, this study suggests that future research on the adoption of ICLFS should take into account herd mobility issues in the adoption process. Finally, it suggests that ICLFS should be taken into account in development policies and implemented through action research projects, mostly in West Africa.

Burst Release from In Situ Forming PLGA-Based Implants: 12 Effectors and Ways of Correction.

This systematic review examines the reasons for the phenomenon of active ingredient "burst" release, which is a major drawback of PLGA-based in situ formed implants, and the likely ways to correct this phenomenon to improve the quality of in situ formed implants with a poly(DL-lactide-co-glycolide) matrix. Actual and relevant publications in PubMed and Google Scholar databases were studied. The concept of the review was based on the theory developed during literature analysis of 12 effectors on burst release from in situ forming implants based on PLGA. Only those studies that sufficiently fully disclosed one or another component of the theory were included. The analysis resulted in development of a systematic approach called the "12 Factor System", which considers various constant and variable, endogenous and exogenous factors that can influence the nature of 'burst release' of active ingredients from PLGA polymer-based in situ formed implants. These factors include matrix porosity, polymer swelling, LA:GA ratio, PLGA end groups, polymer molecular weight, active ingredient structure, polymer concentration, polymer loading with active ingredients, polymer combination, use of co-solvents, addition of excipients, and change of dissolution conditions. This review also considered different types of kinetics of active ingredient release from in situ formed implants and the possibility of using the "burst release" phenomenon to modify the active ingredient release profile at the site of application of this dosage form.

Exploring the linkage between business incubation and entrepreneurship: understanding trends, themes and future research agenda

PurposeThis article aims to conduct a bibliometric study using structural and relational approaches amongst the extracted documents and investigates the connections between business incubation and entrepreneurship-related papers to describe the field comprehensively.Design/methodology/approachA total of 259 articles have been retrieved from Scopus database in order to conduct the bibliometric analysis. Performance analysis and science mapping techniques of bibliometrics have been used along with data visualisation software, i.e. VOSviewer and RStudio. The network collaboration and intellectual structures, i.e. bibliographic coupling, co-occurrence analysis, word cloud and trending topics, have been presented to identify the field’s latest trends, themes and development.FindingsThe findings highlight annual publication trends, including the most frequently cited articles, the most productive authors, countries and highly influential journals that contribute the most to the said field. The intellectual structures have been developed to identify research themes and trends by running co-occurrence analysis and bibliographic coupling. The findings of this study emphasize the value of technology transfer, mentorship programmes, entrepreneurship education and an emphasis on innovation and creativity through entrepreneurial universities and academia. These findings provide policymakers and administrative officials with crucial guidance for fortifying the pillars of entrepreneurship and education for the comprehensive development of the economy. Further, this article attempts to identify the most influential and relevant publications as well as the newest trends in the area of business incubation in combination with entrepreneurship.Research limitations/implicationsThe article contributes not only to broaden the scope of knowledge on the said research discipline but also to comprehend how the field has evolved over a period of time. This study also attracts the interest of scholars/academicians, leading to the significant production of scholarly documents in business incubation and entrepreneurship.Practical implicationsThe field of entrepreneurship and business incubation is one of the important pillars for the growth and development of the economy. This piece contributes to this arena by focusing on the areas that must be taken care of by developing the entrepreneurial ecosystem and fostering the progress of startups. The fundamentals of this research highlight the importance of mentorship programs, entrepreneurship education, technology transfer and a focus on innovation and creativity through entrepreneurial education and efforts by universities/academia, giving an important direction to the policymakers and administration for strengthening the pillar of entrepreneurship and education for the holistic development of the economy.Originality/valueBusiness incubation is an emerging field of academic research connected to startups, venture formation and entrepreneurship ecosystems, making it a potential scholarly discipline. This study presents a thorough bibliometric analysis over the last three decades, offering comprehensive details on the most significant developments in the field of business incubation. Moreover, the various analytical methods applied to this study make it more attractive.

Simulation of visual impairment in persons with normal vision for scientific research.

Simulation of visual impairment in healthy eyes has multiple applications in students' training, research and product development. However, due to the absence of an existing standard protocol, the method of simulation was left to the discretion of the researcher. This review aimed to outline the various methods of simulating visual impairment and categorising them. A scoping review of the relevant publications was conducted. Of the 1593 articles originally retrieved from the databases, 103 were included in the review. The characteristics of the participants, the method for simulation of the visual impairment in persons with normal vision and the level or type of visual impairment that was simulated were extracted from the papers. None of the methods of simulation can be judged as being superior to the others. However, electronic displays produced the most consistent form of visual impairment simulation.

Access to dental care in individuals with disability: a systematic review.

This systematic review was conducted to explore the factors influencing access to oral health services and to identify and examine the strategies to improve the access. PubMed, Scopus and Embase databases were searched. Studies except editorials reported in English regardless of the study design were included. Risk of Bias assessment was carried out using Agency for Healthcare Research and Quality, Newcastle Ottawa Scale and The Joanna Briggs Institute tool for cross-sectional, case-control and cohort and qualitative studies, respectively. In total, 11,372 records were initially identified, eventually leading to 12 relevant publications to be included in the review. Individuals valued oral health but found it difficult to access oral health services. Dental care was mainly accessed during emergencies and participants felt apprehensive in visiting dentists. Caregiver's and dentist's perspective was also reported. There is a need for provision of education, training and increasing awareness on dental hygiene and annual dental checkups to improve access.

Education programmes on performance-based assessment for allied health and nursing clinical educators: A scoping review protocol

Background Performance-based assessment (PBA) is a complex process undertaken in the workplace by healthcare practitioners known as clinical educators, who assist universities in determining health professional students’ readiness for independent practice. Preparing healthcare professionals for PBA is considered essential to ensuring the quality of the assessment process in the clinical learning environment. A preliminary search of the literature indicated a paucity of research guiding the development of education programmes that support practice educators to understand and implement PBA. Objective The aim of this scoping review is to investigate and describe education programmes delivered to allied health and nursing clinical educators, to develop PBA knowledge and skills. Methods This review will follow the Joanna Briggs Institute (JBI) methodology for conducting scoping reviews. Electronic databases relevant to this research topic will be searched including, EMBASE, ERIC, MEDLINE (Ovid), Web of Science and CINAHL and other targeted databases for grey literature. Studies that include PBA as the main focus or a component of the education programmes, of any format, delivered to clinical educators in allied health and nursing will be included. Studies may report the design and/or implementation and/or evaluation of PBA education programmes. Relevant English language publications will be sought from January 2000 to October 2022. Two reviewers will screen all titles and abstracts against the inclusion/exclusion criteria, and publications deemed relevant will be eligible for full text screening, confirming appropriateness for inclusion in the scoping review. Data will be charted to create a table of the results, supported a by narrative summary of the findings in line with the review objectives.

Multimodal business analytics: The concept and its application prospects in economic science and practice

One of the problems of business analysis is obtaining and processing an ever-increasing volume of economic, financial, organizational, political and legal data. Multimodal business analytics is a new methodology combining the methods of classical business analysis with big data technologies, intelligent business analytics, multimodal data fusion, artificial neural networks and deep machine learning. The purpose of the study is to determine the conceptual foundations of the phenomenon of multimodal business analytics and substantiate the prospects for its use in economic science and practice. Methodologically, the study rests on the systems approach, i.e., multimodal business analytics is examined as a unique integrated phenomenon comprised of several interrelated components. The evidence base covers research studies of 2000–2022 on multimodal business analytics from Scopus and the Russian online database eLibrary.ru. Empirical methods were used to collect and evaluate the dynamics of the number of relevant publications and their segmentation by subject areas. We have proposed own thesaurus and ontology of the key terms that make up the phenomenon of multimodal business analytics. It is shown that the use of the concept allows expanding the range of data, exposing hidden interrelations of organizational and economic phenomena and synthesizing fundamentally new information needed for effective decision-making in business.

Analisis Kritis Anggaran Pertahanan: Studi Literatur Tentang Metode Pengelolaan dan Evaluasi

Defense budget is an essential component in a country's defense strategy. The selection of effective methods in managing and evaluating defense budgets can have a significant impact on national defense capabilities. Therefore, this study aims to critically analyze the methods of managing and evaluating defense budgets through relevant literature studies. The method used in this research is literature review, involving the collection and analysis of journals, books, government reports, and other relevant publications. This research involves an in-depth examination of the methods of managing and evaluating defense budgets that have been implemented by countries across the globe. The analysis results indicate that there is significant variation in the approaches to managing and evaluating defense budgets in different countries. Commonly used methods include top-down and bottom-up approaches, cost-benefit analysis, risk analysis, and strategic planning techniques. Furthermore, this research also identifies the challenges faced by countries in managing and evaluating defense budgets, such as political complexity, strategic uncertainty, and resource limitations. This study provides valuable insights into the methods that can be applied in managing and evaluating defense budgets. In the context of national defense planning, a profound understanding of these various methods can assist countries in optimizing their resource allocation, enhancing the efficiency and effectiveness of defense budget management, and strengthening national defense capabilities.
 Keywords: Defense Budget, Budget Management, Budget Evaluation, Defense Strategy, National Defense Planning.

Exosomes in neuron-glia communication: A review on neurodegeneration.

Exosomes, a subset of extracellular vesicles (EVs), are crucial for intercellular communication in various contexts. Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions to cellular functions. Notably, the ability of exosomes to traverse the blood-brain barrier (BBB) has significant implications. To conduct a thorough investigation into the existing academic literature on exosomes within the framework of neuron-glia communication, a comprehensive search strategy was implemented across the PubMed, Google Scholar, and Science Direct databases. Multiple iterations of the keywords "exosome," "neuron-glia communication," and "neurological disorders" were employed to systematically identify relevant publications. Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology. Although the immediate practical applications of exosomes are somewhat limited, their potential as carriers of pathogenic attributes offers promising opportunities for the development of precisely targeted therapeutic strategies for neurological disorders. This review presents a comprehensive overview of contemporary insights into the pivotal roles played by exosomes as agents mediating communication between neurons and glial cells within the central nervous system (CNS). By delving into the intricate dynamics of exosomal communication in the CNS, this review contributes to a deeper understanding of the roles of exosomes in both physiological and pathological processes, thereby paving the way for potential therapeutic advancements in the field of neurological disorders.

A Review of Meaningful Change Thresholds for EORTC QLQ-C30 and FACT-G Within Oncology

ObjectivesThis literature review provides an overview of meaningful change thresholds for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) and the Functional Assessment of Cancer Therapy – General (FACT-G) used across hematological cancers and solid tumors (melanoma, lung, bladder, and prostate). MethodsEmbase, MEDLINE, and PubMed were searched to identify relevant oncology publications from 2016 to 2021. Label claims from the US Food and Drug Administration and the European Medicines Agency for 7 recently approved drugs (pembrolizumab, atezolizumab, glasdegib, gilteritinib, tisagenlecleucel, axicabtagene ciloleucel, and daratumumab plus hyaluronidase-fihj) were reviewed. ResultsPublications providing guidance on meaningful change thresholds for the QLQ-C30 displayed a growing trend away from broad “legacy” thresholds of 10 points for all QLQ-C30 scales), toward deriving “contemporary” thresholds (eg, subscale specific, population specific). Contemporary publications generally provide guidance on selecting thresholds for specific scales that account for improved or worsening thresholds (eg, QLQ-C30 subscales). This trend was not clear for FACT-G, with less new guidance available. Most clinical trials used in regulatory label submissions have used thresholds of 10 points for the QLQ-C30 subscales and 3 to 7 points for the FACT-G total score. Despite the availability of more recent guidelines, contemporary meaningful change thresholds seem slow to emerge in the published literature and regulatory labels. ConclusionsTrialists should consider using contemporary thresholds, rather than legacy thresholds, for QLQ-C30 endpoints. Thresholds derived for a similar patient-population should be used where available. Further work is required to provide these across a broader range of cancer sites.

Revolutionizing diagnostic pathology: The emergence and impact of artificial intelligence—what doesn't kill you makes you stronger?

This study explored the integration and impact of artificial intelligence (AI) in diagnostic pathology, particularly dermatopathology, assessing its challenges and potential solutions for global health care enhancement. A comprehensive literature search in PubMed and Google Scholar, conducted on March 30, 2023, and using terms related to AI, pathology, and machine learning, yielded 44 relevant publications. These were analyzed under themes including the evolution of deep learning in pathology, AI's role in replacing pathologists, development challenges of diagnostic algorithms, clinical implementation hurdles, strategies for practical application in dermatopathology, and future prospects of AI in this field. The findings highlight AI's transformative potential in pathology, underscore the need for ongoing research, collaboration, and regulatory dialogue, and emphasize the importance of addressing the ethical and practical challenges in AI implementation for improved global health care outcomes.

Flash Flood Susceptibility Modelling Using Soft Computing-Based Approaches: From Bibliometric to Meta-Data Analysis and Future Research Directions

In recent years, there has been a growing interest in flood susceptibility modeling. In this study, we conducted a bibliometric analysis followed by a meta-data analysis to capture the nature and evolution of literature, intellectual structure networks, emerging themes, and knowledge gaps in flood susceptibility modeling. Relevant publications were retrieved from the Web of Science database to identify the leading authors, influential journals, and trending articles. The results of the meta-data analysis indicated that hybrid models were the most frequently used prediction models. Results of bibliometric analysis show that GIS, machine learning, statistical models, and the analytical hierarchy process were the central focuses of this research area. The analysis also revealed that slope, elevation, and distance from the river are the most commonly used factors in flood susceptibility modeling. The present study discussed the importance of the resolution of input data, the size and representation of the training sample, other lessons learned, and future research directions in this field.

Cost-Effectiveness and Impact on Health Care Utilization of Interventions to Improve Medication Adherence and Outcomes in Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review

BackgroundPoor adherence to asthma and chronic obstructive pulmonary disease (COPD) maintenance therapies impairs health outcomes. Proven and cost-effective programs to promote adherence and persistence are not yet in widespread, regular use. Implementation costs are a potential barrier to uptake of such programs. ObjectiveWe undertook a systematic literature review and narrative synthesis of studies investigating the cost-effectiveness of treatment adherence-promoting programs or that determined their impact on healthcare budget directly or via healthcare resource utilization (HCRU). MethodsWe identified relevant publications using MEDLINE and PREMEDLINE (PubMed), EMBASE (Embase.com, Elsevier) and EconLit for publications between January 2000 and July 2021. Clinical trial databases and selected conference proceedings were also searched. ResultsOf 1,910 potentially relevant articles, 26 met prespecified inclusion criteria and underwent data extraction. Eleven reported a direct assessment of adherence, 15 included economic evaluations, and 17 described HCRU. None included analysis of biologic medication use. Where studied, interventions were often found to be highly cost-effective, with dominant incremental cost-effectiveness ratios in some cases. Reductions in direct costs and HCRU – healthcare visits, hospital admissions and/or the use of medications (including add-on/reliever treatment and antibiotics) – were reported frequently. Reported use of maintenance treatments improved in some studies. Counseling and/or digitally informed programs were used in all cases where favorable outcomes were observed. ConclusionAdherence-promoting interventions are mostly cost-effective and often result in reduced HCRU and associated costs. Multidisciplinary care involving one-to-one advice and digitally enhanced communications appear to offer the greatest benefit.

The Impact of Mobile Phone Use on Students' Mental Health

The use of mobile phones is becoming more and more widespread, and the time for students to contact mobile phones for the first time is getting earlier and earlier, so it has become necessary and urgent to pay attention to the psychological problems caused by mobile phones for students. This article analyzes the impact of smartphone apps on students' mental health. This paper argues that overuse or incorrect use can cause students to have psychological problems such as anxiety and depression. This may be due to factors such as lack of communication, family influences, etc. Based on this, this article suggests that society should increase the relevant publicity for the correct use of mobile phones. Schools should pay attention to the different psychological problems of different students and provide targeted counseling. Families should communicate more and guide students to take the initiative to express themselves. Students should learn self-control and at the same time, develop good living habits to avoid psychological problems.