Relevant Cues Research Articles

Abstract 2758: Expanding PRISM high-throughput screening capabilities to other modalities

Abstract PRISM, a high-throughput drug screening platform, has been used extensively to profile DMSO-soluble compounds, including nearly all commercially available FDA-approved small molecule drugs, in pools of cancer cell lines. In addition to these highly-optimized compounds, novel small-molecule libraries comprising tens of thousands of compounds have been screened through collaborative partnerships. While PRISM has been highly effective in discovering new therapeutic targets and classes via libraries of this nature, we have not yet explored screening aqueous molecules at scale, such as antibodies, antibody-drug conjugates (ADCs), cytokines, and other biologics. There is also untapped potential for the further development of PRISM-based assays utilizing more physiologically relevant assay conditions to gain new insights into cancer biology and highlight more clinically relevant targets. Specifically, the incorporation of environmental cues such as media nutrients, extracellular matrix, and other non-cancer cell types can have a drastic impact on cancer cell state, and thus cancer cell responses to therapy. For example, PRISM pools grown as 3D spheroids, compared to 2D mono-layers, reveal models showing increased sensitivity to mutant KRAS inhibition. Similarly, the addition of immune effector cells, via co-culture methods, to the PRISM platform will enable identification of key mechanisms involved in antibody-dependent cellular cytotoxicity and measurement of immunotherapeutic-relevant phenotypes at an unprecedented scale. This coupling of aqueous screening, with the addition of relevant tumor-microenvironmental cues may help identify therapies more destined to succeed in the clinic, and delineate novel mechanisms involved in cancer cell-state that underpin the many clinical challenges we face in curing cancer. Citation Format: Jacob Smigiel, Jillian Eskra, Antonella Masciotti, Aydin Golabi, Blanche Ip, Melissa Ronan, Matthew G. Rees, Jennifer Roth. Expanding PRISM high-throughput screening capabilities to other modalities [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2758.

Helpers or halos: examining the evaluative mechanisms underlying selective prosociality.

This research examines the proximate evaluative mechanisms underlying prosocial partner choice-based reciprocity. Across four studies we presented 855 university undergraduates (online for course credit) and 76 4- to 6-year-olds (offline at a university laboratory) with vignettes describing prosocial, social and non-social characters, and asked participants about their person preferences in prosocial, social and general contexts. Adults demonstrated sophisticated appraisals, coordinating between relevant trait and contextual cues to make selections. Adults were particularly attentive to prosocial cues in costly conditions, suggesting that they were using dispositional attributions to make their selections. By contrast, children were largely unable to integrate trait and contextual cues in determining their partner preferences, instead displaying valenced preferences for non-social cues, suggesting the use of affective tagging. Together, these studies demonstrate that the mechanisms underlying prosocial, partner choice-based reciprocity are not early emerging and stable but show considerable development over the lifespan.

The impact of coffee origin information on sensory and hedonic judgment of fine Amazonian robusta coffee

AbstractThrough the lens of predictive processing theory, perception is shaped by expectations we create about object information, including food products, and their match/mismatch with sensory stimuli. The popularity of labelling origin information to enhance product value has been spread to high‐quality foods, particularly as geographical indication (GI). The question we propose is whether the coffee's origin information can affect the sensory perception and hedonic judgment given by professional coffee tasters. Participants were divided into groups according to GI cue provision (absent, GI cue, GI storytelling) associated to the coffee sample served. Origin information proved to significantly affect participants' sensory perception, but not hedonic judgment. Precisely, participants judged acidity and overall flavor as more intense after reading the story whereas higher ratings of nutty, cacao, and caramel notes were given when origin was absent. It is likely that, origin and sorytelling influenced participants' expectations and sensory perception. Oppositely, a better perception of flavor notes was observed only in the absence of information.Practical applicationsThis study contributes to the literature of food marketing by showing that professional coffee tasters' sensory evaluations of specialty coffee are affected by product origin and how it is communicated. These findings emphasize the relevance of origin cues in food marketing and their potential on influencing expectations and sensory perception. Coffee companies and brands can benefit from communicating the origin of specialty coffee by building strategies on place reputation and image. Considering that the specialty coffee industry is growing fast and offers a variety of product options (e.g., organic, fair trade, award winner), new coffee varieties and recently registered GIs can disclose the origin cue to capture consumers' attention and enhance product value by referring to the uniqueness of a region. Additionally, different coffee profiles could be matched with different presentations of the origin cue in order to potentially enhance the consumers' perception of the beverage's attributes, improving the drinking experience.

Free classification as a method for investigating the perception of nonnative sounds

AbstractOur study proposes the use of a free classification task for investigating the dimensions used by listeners in their perception of nonnative sounds and for predicting the perceptual discriminability of nonnative contrasts. In a free classification task, participants freely group auditory stimuli based on their perceived similarity. The results can be used to predict discriminability and can be compared to various acoustic or phonological dimensions to determine the relevant cues for listeners. The viability of this method was examined for both a segmental contrast (German vowels) and a nonsegmental contrast (Finnish phonemic length). Perceptual similarity data from the free classification task accurately predicted discriminability in an oddity task and separately provided rich information on how the perceptual space is shaped. These results suggest that a free classification task and related analyses are informative and replicable methods for examining nonnative speech perception.

Cue transparency leads to a myopic decision habit: Optimal training ratios to avoid overshadowing

Environmental cues to optimal decisions abound. Some are highly predictive and immediately transparent (e.g., amounts) whereas others may either be harder to discern or take time to obtain (e.g., probability and delay). In the present experiment, we manipulated the availability of a particularly salient, and thus dominant, cue regarding when a participant should cash-in when an outcome’s value is increasing over time – a target cube’s size grew as its value grew. For some targets, this expanding cube cue was visible but for others it was not. In contrast, a highly predictive but less obviously relevant color cue was omnipresent, and the recent delay-reward relationship also signaled the reward dynamics. The research addressed a simple question: would more training with transparent targets that reveal the dominant cue produce greater sensitivity to a changing contingency or would more training with opaque targets produce greater sensitivity? Participants’ contingency sensitivity benefitted more when the majority of the training involved opaque targets. Although extensive training with transparent targets produced a strong understanding of reward dynamics, this dominant decision cue undermined attention to secondary cues that are more important in less transparent environments.

A dynamical model of C. elegans thermal preference reveals independent excitatory and inhibitory learning pathways

Caenorhabditis elegans is capable of learning and remembering behaviorally relevant cues such as smells, tastes, and temperature. This is an example of associative learning, a process in which behavior is modified by making associations between various stimuli. Since the mathematical theory of conditioning does not account for some of its salient aspects, such as spontaneous recovery of extinguished associations, accurate modeling of behavior of real animals during conditioning has turned out difficult. Here, we do this in the context of the dynamics of the thermal preference of C. elegans. We quantify C. elegans thermotaxis in response to various conditioning temperatures, starvation durations, and genetic perturbations using a high-resolution microfluidic droplet assay. We model these data comprehensively, within a biologically interpretable, multi-modal framework. We find that the strength of the thermal preference is composed of two independent, genetically separable contributions and requires a model with at least four dynamical variables. One pathway positively associates the experienced temperature independently of food and the other negatively associates with the temperature when food is absent. The multidimensional structure of the association strength provides an explanation for the apparent classical temperature-food association of C. elegans thermal preference and a number of longstanding questions in animal learning, including spontaneous recovery, asymmetric response to appetitive vs. aversive cues, latent inhibition, and generalization among similar cues.

How teaching experience and physics and mathematics content knowledge impact professional noticing skills of STEM graduate students

AbstractThe framework of professional noticing describes three components (attending, interpreting, and deciding) that allow teachers to better understand the thinking of their students. Via this method, teachers attend to their classroom by observing relevant cues from students, interpret these cues based on their knowledge of student development, and decide how best to proceed in their lesson. This study utilized an open‐response survey to collect data regarding the professional noticing skills, physics and mathematics content knowledge, and teaching experience of Science, Technology, Engineering, and Mathematics graduate students. Participants were given a physics and calculus problem to solve to assess their level of content knowledge and then watched a video‐based scenario of a teacher and student discussing the same problems. After, participants were prompted to answer questions corresponding with the attending, interpreting, and deciding components of professional noticing. We found significant results that suggest teaching experience alone is not enough to employ professional noticing skills when attending physics scenarios, and that possessing content knowledge has a positive impact on professional noticing ability, both overall and within the components.

Emotion perception in children with cochlear implants and with hearing aids

Emotion recognition is an important part of human communication and this ability contributes to children’s social development. Children with hearing loss may have difficulties perceiving relevant acoustic cues conveying emotions, but the combined effects of neuroplasticity, physiological effects from hearing loss, and the compensatory features of hearing aids and cochlear implants are not fully understood. As a result, it is also unclear if difficulties in vocal emotion perception are mostly due to a reduced access to relevant acoustic cues, an acute effect. Additionally, the ability to recognize and label emotions may develop differently in children with hearing loss, an accumulated effect over a longer period of time that may be less directly related to hearing difficulties. We will present findings from recent studies on vocal emotion recognition from semantically meaningless sentences in children (6–18 years) with cochlear implants or with hearing aids, and preliminary results from ongoing work on both vocal and facial emotion recognition in hearing aided children (6–18 years). These data show a large variability in performance, indicating some children with hearing loss mayhave great difficulties. We will discuss potentially relevant contributing factors in the development of emotion perception in children with hearing loss.

Evaluating normalization accounts against the dense vowel space of Stockholm Swedish

Talkers vary in the phonetic realization of their vowels. One influential hypothesis holds that listeners overcome this inter-talker variability through pre-linguistic auditory mechanisms that normalize the acoustic or phonetic cues that form the input to speech recognition. Dozens of competing normalization accounts exist —including both vowel-specific (e.g., Lobanov, 1971; Nearey, 1978; Syrdal and Gopal, 1986) and general-purpose accounts applicable to any type of phonetic cue (McMurray and Jongman, 2011). We add to the cross-linguistic literature by comparing normalization accounts against a new database of Swedish, a language with a particularly dense vowel inventory of 21 vowels differing in quality and quantity. We train Bayesian ideal observers (IOs) on unnormalized or normalized vowel data under different assumptions about the relevant cues to vowel identity (F0-F3, vowel duration), and evaluate their performance in predicting the category intended by talker. The results indicate that the best-performing normalization accounts centered and/or scaled formants by talker (e.g., Lobanov), replicating previous findings for other languages with less dense vowel spaces. The relative advantage of Lobanov decreased when including additional cues, indicating that simple centering relative to the talker’s mean might be sufficient to achieve robust inter-talker perception (e.g., C-CuRE).

Spatial voting in non-partisan cities: A case study

In spatial voting theory, voters choose the candidate whose policy preferences are most like their own. This requires that (a) voters and candidates have policy preferences that can be meaningfully summarized in terms of low-dimensional “ideal points” on a left-right scale; (b) voters are able to discern, either directly or through relevant cues, the ideal points of the candidates who are running for office; and (c) voters incorporate this information into the choices they make at the ballot box. Perhaps more than in any other elections, it is not clear that any of these requirements are met in non-partisan municipal elections: policy preferences may not be ideologically structured, information may be inadequate, and voters may choose candidates for reasons other than ideology. This makes non-partisan municipal elections an especially hard test for spatial voting theory. Using novel data from both municipal candidates and eligible voters in a major non-partisan municipal election in Canada, we show that municipal policy attitudes are ideologically structured and that these municipal policy ideal points are strongly related to mayoral and council vote choice. Thus, despite the institutional and informational obstacles, spatial voting can play an important role in non-partisan municipal elections.

Nudges and choice architecture to promote healthy food purchases in adults: A systematized review.

Consistent with behavioral economic models that emphasize the context-dependance of behavioral choice, choice architecture strategies change the environmental context to promote or nudge healthier choices including the healthfulness of food purchases that may help reduce disease and premature death. This review summarizes research that investigated nudging interventions to promote healthful food purchase choices among adults. A comprehensive systematized search strategy identified research published since 2009 that investigated the role of nudges and choice architecture interventions on adult food purchasing decisions with behavioral outcomes. Study data were extracted and summarized regarding nudge characteristics, design features, study quality, and food purchasing outcomes. The search identified 1,129 articles, 33 of which met inclusion criteria. Twelve studies were rated as high quality, 21 as neutral, and none as low quality. Some evidence of effectiveness was found for priming nudges that manipulated physical, verbal, or sensational cues to promote healthy choices (8 of 11 studies); salience and affect nudges that used novel or personally relevant cues to direct attention to healthy choices (3/3); messenger nudges that presented information on socially normative food choices (2/2), and default nudges that made healthy options the preset choice (1/2). In studies that combined nudge types, combining priming and salience and affect nudges was at least partially effective in 5 of 5 studies. Nudge applications in food purchasing settings, particularly priming, offers a promising public health strategy to encourage healthier food choices among adults. More research is needed to determine optimal nudge combinations and contexts. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

"I Assumed It Would Be Somebody Who Had a Stroke That Was Doing This": Views of Stroke Survivors, Caregivers, and Health Professionals on Tailoring a Relaxation and Mindfulness Intervention.

Stroke survivors and informal caregivers experience high levels of stress and anxiety, linked to heightened risk of secondary stroke in survivors. Relaxation and mindfulness could reduce stress and anxiety; being most effective when tailored to the target populations. Aims of the PPI include to: (1) consult on possible alterations to an existing relaxation and mindfulness intervention, delivered via YouTube/DVD and (2) discuss relevance and preference of prompts and cues designed to facilitate the daily practice of the intervention. Eleven UK PPI contributors were consulted during 2020: four stroke survivors (F = 2, M = 2), three caregivers (F = 1, M = 2), and four HCPs (F = 4) (range = 23-63 years). Contributors watched the existing intervention and provided feedback via online discussions. Transcripts were analysed using thematic analysis. Five themes were identified, highlighting several necessary alterations to the intervention: "Who represents the stroke population?"; "The paradox of age"; "Specifically selected language"; "Visual presentation of the intervention"; and the "Audio qualities". Contributors ranked the prompts and cues in order of preference with setting alarms and email alerts as the most popular. The PPI consultations resulted in several alterations enabling a revised version of the intervention. Including a PPI consultation at an early stage of the research improves the relevance and appropriateness of the research. The revised intervention is more representative of the stroke population thus more likely to be practised by survivors and caregivers, which will enhance the extent of effectiveness, reducing the risk of a secondary stroke.

Plain-to-clear speech video conversion for enhanced intelligibility

Clearly articulated speech, relative to plain-style speech, has been shown to improve intelligibility. We examine if visible speech cues in video only can be systematically modified to enhance clear-speech visual features and improve intelligibility. We extract clear-speech visual features of English words varying in vowels produced by multiple male and female talkers. Via a frame-by-frame image-warping based video generation method with a controllable parameter (displacement factor), we apply the extracted clear-speech visual features to videos of plain speech to synthesize clear speech videos. We evaluate the generated videos using a robust, state of the art AI Lip Reader as well as human intelligibility testing. The contributions of this study are: (1) we successfully extract relevant visual cues for video modifications across speech styles, and have achieved enhanced intelligibility for AI; (2) this work suggests that universal talker-independent clear-speech features may be utilized to modify any talker’s visual speech style; (3) we introduce “displacement factor” as a way of systematically scaling the magnitude of displacement modifications between speech styles; and (4) the high definition generated videos make them ideal candidates for human-centric intelligibility and perceptual training studies.

Eye-Gaze direction triggers a more specific attentional orienting compared to arrows.

Numerous studies have shown that eye-gaze and arrows automatically shift visuospatial attention. Nonetheless, it remains unclear whether the attentional shifts triggered by these two types of stimuli differ in some important aspects. It has been suggested that an important difference may reside in how people select objects in response to these two types of cues, eye-gaze eliciting a more specific attentional orienting than arrows. To assess this hypothesis, we examined whether the allocation of the attentional orienting triggered by eye-gaze and arrows is modulated by the presence and the distribution of reference objects (i.e., placeholders) on the scene. Following central cues, targets were presented either in an empty visual field or within one of six placeholders on each trial. In Experiment 2, placeholder-objects were grouped following the gestalt's law of proximity, whereas in Experiment 1, they were not perceptually grouped. Results showed that cueing one of the grouped placeholders spreads attention across the whole group of placeholder-objects when arrow cues were used, while it restricted attention to the specific cued placeholder when eye-gaze cues were used. No differences between the two types of cues were observed when placeholder-objects were not grouped within the cued hemifield, or no placeholders were displayed on the scene. These findings are consistent with the idea that socially relevant gaze cues encourage a more specific attentional orienting than arrow cues and provide new insight into the boundary conditions necessary to observe this dissociation.

A lexical-availability-based framework from short communications for automatic personality identification

We store and retrieve words from our brain during a communicative intention. These words form what linguistics and psycholinguistics refer to as the mental lexicon —a cognitive construct—. In this paper, we study the effectiveness of such a cognitive-based model for selecting the relevant lexicon that an automatic classifier can leverage for learning to distinguish personality traits from short communication intentions. Our proposed approach can automatically detect lexical units that are more suitable to train a machine learning algorithm to identify a subject’s personality trait. We evaluated our method in two Mexican Spanish datasets, labeled according to the Big Five personality model. Experimental results indicate some personality traits are more transparent than others, e.g., Extroversion and Openness with 71% and 72% F-scores, respectively. An analysis of the information our proposed method selects identifies relevant psycholinguistic cues that complement psychologists’ a prior knowledge. Overall, contrary to deep NNs based models, our proposed approach represents a less expensive and more interpretable technique, the desired combination for systems that aim to support the decisions made by a specialist.

Haptic shared control improves neural efficiency during myoelectric prosthesis use

Clinical myoelectric prostheses lack the sensory feedback and sufficient dexterity required to complete activities of daily living efficiently and accurately. Providing haptic feedback of relevant environmental cues to the user or imbuing the prosthesis with autonomous control authority have been separately shown to improve prosthesis utility. Few studies, however, have investigated the effect of combining these two approaches in a shared control paradigm, and none have evaluated such an approach from the perspective of neural efficiency (the relationship between task performance and mental effort measured directly from the brain). In this work, we analyzed the neural efficiency of 30 non-amputee participants in a grasp-and-lift task of a brittle object. Here, a myoelectric prosthesis featuring vibrotactile feedback of grip force and autonomous control of grasping was compared with a standard myoelectric prosthesis with and without vibrotactile feedback. As a measure of mental effort, we captured the prefrontal cortex activity changes using functional near infrared spectroscopy during the experiment. It was expected that the prosthesis with haptic shared control would improve both task performance and mental effort compared to the standard prosthesis. Results showed that only the haptic shared control system enabled users to achieve high neural efficiency, and that vibrotactile feedback was important for grasping with the appropriate grip force. These results indicate that the haptic shared control system synergistically combines the benefits of haptic feedback and autonomous controllers, and is well-poised to inform such hybrid advancements in myoelectric prosthesis technology.

A new technique for estimating the probability of attentional capture.

Latency-based metrics of attentional capture are limited: They indicate whether or not capture occurred, but they do not indicate how often capture occurred. The present study introduces a new technique for estimating the probability of capture. In a spatial cueing paradigm, participants searched for a target letter defined by color while attempting to ignore salient cues that were drawn in either a relevant or irrelevant color. The results demonstrated the typical contingent capture effect: larger cue validity effects from relevant cues than irrelevant cues. Importantly, using a novel analytical approach, we were able to estimate the probability that the salient cue captured attention. This approach revealed a surprisingly low probability of attentional capture in the spatial cuing paradigm. Relevant cues are thought to be one of the strongest attractors of attention, yet they were estimated to capture attention on only about 30% of trials. This new metric provides an index of capture strength that can be meaningfully compared across different experimental contexts, which was not possible until now.

Evaluation of lion (Panthera leo) scat as a wild dog (Lycaon pictus) deterrent on game farms

Context The conservation of the Endangered African wild dog (Lycaon pictus) poses a major challenge to conservationists because outside the boundaries of protected areas, wild dogs are prone to conflict with farmers. Mitigation measures appropriate for game farmers are scarce, leaving them with limited options to reduce wild dog impact. As a result, targeted persecution is a common occurrence. However, wild dogs are subject to intraguild competition with dominant competitors, often resulting in their suppression and spatial displacement. Therefore, olfactory cues of lion presence may trigger an adverse reaction in wild dogs, and could be a means to manage wild dog movements across the landscape to prevent conflict with farmers. Aim We aimed to evaluate whether wild dogs can be deterred by simulating lion presence. Methods By using translocated scent cues in the form of lion scat deployed along the perimeter of plots, lion presence was simulated on game farms where lions were absent. The rate and duration of incursions by wild dogs, collared with GPS trackers, into control and treatment plots (‘group’) were evaluated. Key results Wild dog incursion rate dropped by 55.5%, and duration of incursion events dropped by 72.7%, after lion scat was deposited. Control and treatment plots were equally affected with no significant effect of the grouping on wild dog movement. The magnitude of the treatment effect differed between packs. Conclusion The significant decline of wild dog movement after implementation of treatment suggests a deterrence effect. The insignificant effect of group on wild dog movement indicates large-scale avoidance triggered by a change in the wild dogs’ risk perception across the landscape following treatment. The fact that the magnitude of the treatment effect differed between packs indicates that the response to predator cues is likely to be context-dependent. Implications The findings present a novel approach to managing free-roaming wild dogs by utilising biologically relevant cues, which may benefit wild dog conservation. There is a need for further research to develop the emerging field of scent studies to provide non-lethal solutions and progress towards evidence-based large carnivore management practices.

To Share or Not to Share: A Framing Analysis of Paid Vaccine Advertisements on Facebook during COVID-19 and Pro-Vaccine Mothers’ Willingness to Promote Vaccines within Their Peer Networks

Two studies in this line of research explored paid vaccine-related advertisements on Facebook from March to May 2020 at the outset of COVID-19 and how this content could influence message sharing. Study 1 included a framing analysis of vaccine ads collected from the Facebook Ad Library. Overarching pro-vaccine frames included: (i) support for vaccines and (ii2) dual benefits – individual and community protection. On the other hand, anti-vaccine messages emphasized the necessity of individual liberty. COVID-19-specific frames included (i) vaccine development and politicization and (ii2) the pandemic as a tangible backdrop to illustrate the need for vaccines, holistically. Study 2 included interviews with vaccine-accepting mothers to understand their perceptions of the most prevalent ad frames identified in Study 1, through the lens of Source Credibility Theory, and their willingness to share these messages. Five overarching themes emerged. Relevant credibility cues included sponsor, image selection, spokesperson, wording, and attitude homophily. Key findings for advertising practitioners and public health communicators include the politicization of vaccines on Facebook, the need for neutral, credible sources and medical provider buy-in, and the need for a change in message emphasis. Notably, this research highlights the critical role of advertising platform selection to effectively promote vaccines on social media.

Risk perception and behavioral intentions in facing compound climate-related hazards

Compound climate-related events are a complex combination of climate drivers and hazards leading to a significant impact on natural and anthropic systems. Owing to their complexity and critical consequences, interdisciplinary undertaking is required to improve risk analysis, management, and communication. Although prior research in cognitive sciences extensively investigated risk perception in case of a single hazard, the analysis of compound hazards perception is still an open issue. Here, based on cognitive psychology insights, we empirically investigate how individuals' risk perception is shaped by the subjective relevance attributed to different causal cues entailed in a compound event scenario. The results revealed that the subjective validity assigned to specific evidence presented in the composite scenario leads perceived risk related to one of the outcomes (i.e., flooding and wildfire) to prevail over the other. Moreover, the relevance of different cues is likely to affect participants' automatic behavioral intentions (stay at home vs. evacuation).