Understanding and simulating the hydrological cycle, especially in a context of climate change, is crucial for quantitative water risk assessment and basin management. The hydrological cycle is complex as it is a combination of non-linear natural processes and anthropogenic influences that alter landforms and water flows. Human-induced changes of relevance, including changes in land uses, construction of dams and artificial reservoirs, and diversion of the river course, lead to changes in water flows throughout the basin. These should be explicitly accounted for a realistic representation of the anthropogenically altered hydrological cycle. Such a realistic representation of the hydrological cycle is a necessary input for the water risk assessment in a particular region. In this paper, we present a hydrological digital twin (HDT) model of a large anthropized alpine basin: the Adige basin located in the northeast of Italy.Most catchments model often overlook land-uses changes over time and forget to model reservoir operation and their influence over time on water flow. Yet, for example, the Adige basin has>30 reservoirs affecting the water flow. We therefore use the GEOframe modeling framework to demonstrate the ability to create a hydrological twin model accounting for these anthropogenic changes.Specifically, we model each component of the water cycle over 39 years (1980–2018) at daily timescale through calibration of the Adige HDT with a multi-site approach using discharge data of 33 stations, based on a high-resolution (1 km) temperature and precipitation dataset and a calculated crop potential evapotranspiration (PETc) dataset, which accounts for human-induced change of the land cover over time. The modeling system also includes the simulation of artificial reservoirs and dams by the dynamically zoned target release (DZTR) reservoir model.The Adige HDT is assessed/validated/compared through a variety of hydrological processes (i.e., river and reservoir discharges, PETc and actual evapotranspiration, snow, and soil moisture) and data sources (i.e., observations and remote sensing data).Overall, the HDT reproduces well the measured discharge in space and time with a Kling Gupta Efficiency (KGE) above 0.7 (0.8) for 30 (23) of the 33 gauge-stations. For 7 artificial reservoirs with available data, the reservoir turbinated discharges are successfully reproduced with an average KGE of 0.92. A comparison between modeled and MODIS remote sensing snow data showed an average error of < 10% across the entire basin; the model also presented a good spatio-temporal agreement both with GLEAMS potential (and actual evapotranspiration) with an average KGE of 0.63 (0.60) and a high-level of correlation (0.5 on average) with the ASCAT satellite retrieved soil moisture.The findings of this paper demonstrate the potential of the open-source, component-based, GEOframe system to build a HDT, to provide a reliable and long term (39 years) estimation of all the water cycle components in a complex anthropized river basin at high spatial resolution. Spatially detailed HDT models results of this type can be used to inform basin-wise adaptation policy decisions and better water management practices in a time of changing climate.