Relevant Articles Research Articles

The impact of usability in information technology projects

Achieving success in information system and technology (IS/IT) projects is a complex and multifaceted endeavour that has proven difficult. The literature is replete with project failures, but identifying the critical success factors contributing to favourable outcomes remains challenging. The triad of Time-Cost-Quality is widely accepted as key to achieving project success. While time and cost can be quantified and measured, quality is a more complex construct that requires different metrics and measurement approaches. Utilizing the PRISMA Methodology, this study initiated a comprehensive search across literature databases and identified 142 relevant articles pertaining to the specified keywords. A subset of ten articles was deemed suitable for further examination through rigorous screening and eligibility assessments. Notably, a primary finding indicates that despite recognizing usability as a critical element, there is a tendency to neglect usability enhancements due to time and resource constraints. Regarding the influence of usability on project success, the active involvement of end-users emerges as a pivotal factor. Moreover, fostering the enhancement of Human-Computer Interaction (HCI) knowledge within the development team is essential. Failure to provide good usability can lead to project failure, undermining user satisfaction and adoption of the technology.

Comparison between novel zipper device and conventional methods for skin closure: a systematic review and meta-analysis.

The zipper device is a wound closure device that can be directly applied over the intact skin on either side of the wound edges and does not need anchoring into the skin or subcutaneous plane. The noninvasive nature of the zipper device makes it less time-consuming and less painful, but its effectiveness and related complications need to be studied. Prospective registration of the protocol followed in this study was done. Electronic databases were searched for relevant articles, and their screening was completed, followed by data extraction and analysis. The odds ratio, mean difference, or standardised mean difference were used as an effect measure per the nature of the variables. Surgical site infection, wound dehiscence, skin closure time, scar score, and patient satisfaction were compared in this study. A total of 10 studies were identified, out of which eight compared zippers with sutures and two compared zippers with stapler devices. Compared to the suture, the zipper device took 4.9 min less to close the incision, and the scar scale outcome reported after one month was inferior, while other results were not significant. Staples showed a lower patient satisfaction level and no difference in complications. The zipper device is a less technically demanding and less time-consuming method of skin closure, with no significant difference in the complication rate compared to conventional methods. The zipper device is an effective measure to use in settings with less expertise or at health institutions after assessing the cost at the local level.

Mental health service utilization and help seeking behaviours of adult Cambodians living in Western countries: A systematic scoping review.

Health disparity and under-utilization of health services is prevalent among Asian refugees and migrants in Western countries and can profoundly impact health outcomes. Cambodians who survived extreme physical and emotional trauma during the genocides enacted by the Khmer Rouge regime in the 1970's are particularly vulnerable to poor mental health outcomes decades later. Understanding the experiences of help-seeking and service use by displaced Cambodians in Western countries may help to design more effective and culturally safe healthcare services. To identify characteristics or factors associated with help seeking behaviours and service utilization of displaced Cambodians with mental health issues living in Western countries. This review followed the Arksey & O'Malley methodological framework for scoping reviews. Articles for review were identified through searches of nine electronic databases and manual searches. Relevant articles were selected, and data was extracted and synthesized into key themes. This review included 15 articles. Most of the studies were conducted in the USA (n = 13) with one each conducted in Canada and New Zealand. Seven studies used qualitative interviews, five used a cross-sectional survey approach, two used a mixed-methods approach and one was a narrative review and case series. Key findings highlighted the impact of Cambodian cultural beliefs about mental health (guilt, shame and help-seeking stigma) on service utilization and the disconnect between Western models of service provision and preferred Cambodian ways of receiving support. Mental health services in Western countries are likely to be under-utilized by Cambodians due to a mismatch between health beliefs and Western models of care. Further investigation of the association between health beliefs and barriers to service utilization among adult Cambodian refugees is warranted.

Medicinal Plants and Natural Antioxidants Effective Against Corona: A Systematic Review

Background:: Coronavirus disease 2019 or COVID-19 is a type of acute respiratory syndrome caused by a virus from the family of coronaviruses that has affected all the countries of the world in a short period. Objective:: The purpose of this review is to identify and report medicinal plants effective against covid-19. In this study, the keywords containing medicinal plants and "corona disease" i.e. covid-19, MERS, SARS-CoV-2, and medicinal plants or natural antioxidants were used. Methodology:: Search databases including ISI, Scopus, Science Direct, Google Scholar, Mag Iran, and SID were used. Relevant articles were selected and unrelated articles were excluded. Results:: Based on the obtained results, medicinal plants such as Isatis indigotica Fortune, Bupleurum spp., Curcuma longa L., Cibotium barometz (L.), Rheum palmatum L., Rheum palmatum L., Sprag, Scutettaria baicalensis Georg, Alnus japonica (Thunb.) Steud, Camellia sinensis (L.) Kuntze, Salvia miltiorrhiza Bunge, Paulownia tomentosa (Thunb.) Steud. Salvia miltiorrhiza Bunge, Tribulus terrestris L, Broussonetia papyrifera (L.) Vent., Stephania tetrandra S. Moore and related species, Sambucus formosana Nakai, Strobilanthes cusia, Lycoris radiata, E. purpurea, Lobelia inflata, Eupatorium perfoliatum, and Achyranthes aspera are the most important medicinal plants that are used in the treatment of Covid-19. Conclusion:: Due to having secondary metabolites and antioxidant activity, medicinal plants have a favorable effect in improving corona symptoms in patients with covid-19.

Onion (Allium cepa L.) and Drought: Current Situation and Perspectives.

Onions (Allium cepa L.) are the second most commonly produced and consumed vegetable worldwide due to their economic, nutritional, and medicinal benefits. However, drought hinders vegetative growth, lowers yields and bulb quality, reduces photosynthetic activity, and alters the onion plant's metabolism. This review provides a summary of global research on the impact of drought on onions. It specifically seeks to shed light on aspects that remain unclear and generate research avenues. Relevant scientific articles were sourced from the AGORA database, Web of Science (WoS), and search engines such as Google Scholar, Scopus, MEDLINE/PubMed, and SCImago to achieve this objective. A total of 117 scientific articles and documents related to onion and drought were critically examined. The review revealed agromorphological, physiological, biochemical, and genomic studies depicting factors that contribute to drought tolerance in onion genotypes. However, there was little research on the physiological, biochemical, and genetic characteristics of drought tolerance in onions, which need to be deepened to establish its adaptation mechanisms. Understanding the mechanisms of onion response to water stress will contribute to fast-tracking the development of drought-tolerant genotypes and optimize onion production. Future research should be more focused on investigating onion drought tolerance mechanisms and structural and functional genomics and identifying genes responsible for onion drought tolerance.

The influence of leadership and financial performance on business sustainability in microfinance institutions

Microfinance institutions (MFIs) play a pivotal role in empowering marginalized communities by providing them with crucial financial services. The sustainability of these institutions is essential to ensure a sustained positive impact on the lives of the underserved. To explore the factors influencing MFI sustainability, this study conducts a systematic literature review of relevant articles published between 2015 and 2023, focusing on the roles of leadership and financial performance. The findings of the study reveal a compelling positive correlation between effective leadership and financial performance with MFI sustainability. A strong and visionary leadership within MFIs is found to foster a robust organizational culture, articulate a clear vision, motivate employees, and effectively manage risks. These leadership qualities, in turn, contribute significantly to improved financial outcomes for the institution. Conversely, the study highlights the integral role of strong financial performance in ensuring MFI sustainability. A well-performing financial structure not only instills trust among customers but also facilitates business growth and secures vital profits. These financial strengths are crucial pillars that fortify the overall sustainability of MFIs, enabling them to continue their mission of empowering marginalized communities. In conclusion, this study underscores the critical interplay between leadership and financial performance in driving MFI sustainability. The recommendations derived from the findings emphasize the importance of investing in leadership development within MFIs and implementing robust financial practices.

Assessing risks and adverse effects of naphazoline hydrochloride: a literature review (2013-2023)

This study examines the risks and harms associated with the use of naphazoline hydrochloride (NHC). The methodology involved a narrative literature review from 2013 to 2023 in Portuguese, English, and Spanish, which identified eleven relevant articles from Scielo, Medline Complete, PubMed, and Google Scholar. The guiding question was: What are the risks and potential adverse effects associated with the use of NHC? Results and Discussion: Pharmacists play a crucial role in educating against misuse and promoting responsible medication use. However, challenges arise due to the prevalence of self-medication and limited pharmacist involvement in prescribing. The Role of Pharmacists: Harms of Misuse: Key concerns identified include systemic effects, drug-induced rhinitis, and dependence. Overuse of NHC during pregnancy and in children can lead to serious consequences such as hypothermia, bradycardia, and nervous system depression. The abuse hazards of NHC include rebound effects, drug-induced rhinitis, and long-term health risks such as hypertension and heart problems. Conclusion: The study emphasizes the pressing need for enhanced pharmacist training to equip them to effectively counsel and prevent misuse. Additionally, increased public awareness campaigns should be implemented to promote responsible non-prescription healthcare (NHC) use. Stricter dispensing measures, such as regulations to restrict over-the-counter access, should also be put in place. It is essential to promote responsible NHC use. Pharmacists play a critical role in mitigating the risks associated with this widely used medication as public health educators and patient guides.

Effectiveness of Internet Addiction Interventions in Adolescents: Systematic Review

Internet users are increasing and making the internet an important part of life, especially among teenagers, so that teenagers are more vulnerable to experiencing internet addiction. Internet addiction in adolescents can affect school success, social activities, and the student's interaction with the family. Programs to overcome internet addiction problems need to be developed and evaluated. The development of evidence-based programs will have an impact on increasing efficiency, so that it can contribute to the formation of health-improving behavior in adolescents. To evaluate the effectiveness of internet addiction interventions in adolescents, researchers conducted a systematic search of published research articles. Three databases, including PubMed, Science Direct, and Scopus were used to select relevant articles. These articles were selected based on criteria. Then 10 RCT articles were selected for analysis. The results show that the cognitive therapy program intervention is effective in reducing internet addiction

Etiological Factors Affecting Female Sexuality: A Systematic Review

Introduction: Evidence suggests that masturbation, genital stimulation, body awareness and movement, pelvic floor exercises, depression, anxiety, positive and negative feelings, personality type, emotional and overall well-being and emotional intelligence have been studied in association with female orgasm through the years. Additionally, healthcare providers of sexual health and most women lack information regarding sexual satisfaction and reaching orgasm. Few studies have addressed this issue. Aim: To systematically study the effect of social, behavioral, and psychological factors on female orgasm. Methods: An extensive search was conducted in PubMed, CINAHL, Google Scholar and Scopus, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Statement (PRISMA) guidelines, for relevant articles published between June 2002 and June 2022. Studies in languages other than English were excluded. The following Medical Subject Headings (MeSH) terms were used: female, orgasm, psychological, behavioral, social, sexual. Inclusion criteria concerned studies that sampled adult healthy women, used quantitative methodology and explored factors influencing sexual satisfaction. Results: Out of 531 studies, forty-five were further screened. A total of twenty-one studies were reviewed, most of which were conducted in the USA, Portugal and the United Kingdom. They were followed by Switzerland, Iran, Brazil, Sweden, Canada, Hungary and the Netherlands. Four major themes influencing female sexual satisfaction emerged from the synthesis: psychological disorders, psychological background, genital stimulation, body awareness and movement. Conclusions: The female orgasm was influenced by a number of factors, some of which adversely affected it.

Protocol for a systematic review and critical discourse analysis of research on HIV pre-exposure prophylaxis programme use among gay, bisexual, and other men who have sex with men

Background HIV pre-exposure prophylaxis (PrEP) is a pill that prevents the transmission of HIV from sexual partners living with HIV; it is frequently taken by gay, bisexual, and other men who have sex with men (gbMSM). PrEP is often provided through formal PrEP programmes. Research on these programmes may employ discourses shaped by heteronormativity and homophobia. Given that expert language influences how HIV prevention is understood and delivered, problematic discourses in research likely extends into PrEP programme implementation. This review will use critical discourse analysis (CDA) to explore research on PrEP programme implementation for gbMSM. Within this literature, we will identify interpretive repertoires used to discuss gbMSM; the subject positions afforded to gbMSM; and the implications of these interpretive repertoires and subject positions for gbMSM engaging with HIV PrEP programmes. Methods Relevant articles will be identified through timebound searching (2012-present) in ProQuest ASSIA, EBSCOhost PsycInfo, OVID Medline, OVID Embase, and EBSCOhost CINAHL, with forward and backward citation searching of included studies. Grey literature will be identified through ProQuest and Google Scholar. Screening will be conducted by two independent reviewers, who will conduct double screening for titles, abstracts, and full texts. Data will be analysed and synthesised using CDA informed by critical realism (CR). CDA focuses on relationships between language and power, including how language enables inequality. The analytic process will explore the background of included studies, identify overarching themes, analyse external and internal relations in included studies, and interpret the meaning of identified themes and relations. Conclusions Highlighting issues with discourses in PrEP implementation may enhance reflective engagement with assumptions underlying this research, preventing further stigmatisation of gbMSM’s sexual and protective practices. As PrEP programmes become more common globally, more diverse and inclusive perspectives in PrEP programme research may inform interventions that enhance their acceptability and ultimately their implementation.

A Review of the Optimal Effects of Sunscreen Usage in Women Residing in Tropical Climate Regions for Melasma Prevention: Insights from Literature Analysis

Melasma is a hyperpigmented patch that is generally found on the face, especially on the cheeks, chin, upper lip, and can extend to the neck. The color of hyperpigmentation in melasma varies, generally light brown to black with an irregular shape. Melasma is often found in countries with tropical climates with skin types III-V. This happens because countries with these climates are exposed to more sunlight. To reduce excessive UV exposure to the skin, you can use sunscreen. Optimal use of sunscreen must also be considered in order to reduce the incidence of melasma. This literature review uses four databases (Google scholar, PUBMED, NCBI and PERDOSKI) using the relevant keywords namely "melasma" and "sunscreen" to find the source of articles published in 2010 to 2022. The search results get 142 articles. in Indonesian and English. After selecting based on inclusion and exclusion criteria, 14 relevant articles were obtained which will be discussed in this literature review. In this literature review, the results show that there is a significant relationship between optimal use of sunscreen for women in countries with tropical climates, especially Asia, and the incidence of melasma. Melasma occurs mostly in women with Fitzpatrick III-V skin types and is susceptible to age 25-60 years. Patients with melasma who used sunscreen optimally by applying it every 2 hours showed a decrease in the degree of severity of melasma compared to those who did not repeat the use of sunscreen.

Deep learning-based lung nodule detection: a review

CT scan acquisition is fast and cost-effective and has become the main lung imaging tool. However, the increase in large numbers of CT scans has placed a heavy burden on radiologists; therefore, automated lung nodule detection techniques are needed to reduce the workload of radiologists and computer-aided detection systems are proposed for further accurate diagnosis of the condition. This review provides a comprehensive overview of recent automated lung nodule detection techniques and challenges, etc., as well as a detailed overview and discussion of current research gaps, future developments, and research trends. Relevant articles published in databases such as IEEE Xplore, Science Direct, PubMed, and Web of Science cover research algorithms published from 2014 to 2023, mainly discussing deep learning-based techniques. The schemes presented in these articles, the databases used, the experimental results, and the performance of the algorithms are compared and discussed. This work aims to introduce researchers and readers to the latest techniques and their advances in the detection of lung nodules in the last decade, which will help researchers and radiologists to further understand the latest techniques in this field.

Performance of the Asia-Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: A meta-analysis and systematic review.

This study systematically reviewed and meta-analyzed the performance of the Asia-Pacific Colorectal Screening (APCS) score and its incorporation with the fecal immunochemical test (FIT) in stratifying the risk of advanced colorectal neoplasia (ACN). We systematically searched for relevant articles in 12 electronic databases and registers on October 20, 2021, and updated the search to September 1, 2023. Random-effect models were used to obtain the pooled performance statistics of the APCS score for ACN risk. From the 101 records screened, 13 eligible studies in the Asia-Pacific region involving 69762 subjects who had undergone colonoscopy were enrolled. The pooled prevalences of ACN in the average-risk (AR) tier (APCS 0-1), moderate-risk (MR) tier (APCS 2-3), and high-risk (HR) tier (APCS≥4) groups were 0.9%, 3.1%, and 8.1%, respectively. Compared with the combined AR-MR group, the HR group was significantly associated with a higher ACN risk (pooled diagnostic odds ratio: 2.84, 95% confidence interval [CI]: 2.35-3.45, P<0.001). The APCS score showed a sensitivity of 0.42 (95% CI: 0.40-0.44) and a specificity of 0.86 (95% CI: 0.85-0.86) for predicting the ACN risk, with a weighted area under the curve of 0.642 (95% CI: 0.610-0.657). The combination of the APCS score and FIT substantially improved ACN risk identification, demonstrating pooled diagnostic odds ratios of 4.02 (95% CI: 2.50-6.49) in the AR-MR groups and 5.44 (95% CI: 1.89-15.63) in the MR-HR groups. The APCS score could effectively stratify the ACN risk in the Asia-Pacific population. Incorporating FIT further improves its performance in identifying high-risk subjects who should be prioritized for colonoscopy screenings.

Cost-Effectiveness of Treatment Optimisation with Biomarkers for Immunotherapy in Solid Tumours: A Systematic Review.

This study investigated the health economic evaluations of predictive biomarker testing in solid tumours treated with immune checkpoint inhibitors (ICIs). Searching PubMed, EMBASE, and Web of Science from June 2010 to February 2022, 58 relevant articles were reviewed out of the 730 screened. The focus was predominantly on non-small cell lung cancer (NSCLC) (65%) and other solid tumours (40%). Among the NSCLC studies, 21 out of 35 demonstrated cost-effectiveness, notably for pembrolizumab as first-line treatment when preceded by PD-L1 assessment, cost-effective at a threshold of $100,000/QALY compared to the standard of care. However, for bladder, cervical, and triple-negative breast cancers (TNBCs), no economic evaluations met the affordability threshold of $100,000/QALY. Overall, the review highlights a certain degree of uncertainty about the cost-effectiveness of ICI. In particular, we found PD-L1 expression associated with ICI treatment to be a cost-effective strategy, particularly in NSCLC, urothelial, and renal cell carcinoma. The findings suggest the potential value of predictive biomarker testing, specifically with pembrolizumab in NSCLC, while indicating challenges in achieving cost-effectiveness for certain other solid tumours.

Advances in the use of dried blood spots on filter paper to monitor kidney disease

Patients with kidney disease require frequent blood tests to monitor their kidney function, which is particularly difficult for young children and the elderly. For these people, the standard method is to evaluate serum creatinine or cystatin C or drug levels through venous sampling, but more recently, evaluation using dried blood spots has been used. This narrative review reports information from the literature on the use of dried blood spots to quantify the main markers used to detect kidney diseases. The ScienceDirect and PubMed databases were searched using the keywords: “dried blood on filter paper,” “markers of renal function,” “renal function,” “creatinine,” “cystatin C,” “urea,” “iohexol,” and “iotalamate.” Studies using animal samples were excluded, and only relevant articles in English or Spanish were considered. Creatinine was the most assessed biomarker in studies using dried blood spots to monitor kidney function, showing good performance in samples whose hematocrit levels were within normal reference values. According to the included studies, dried blood spots are a practical monitoring alternative for kidney disease. Validation parameters, such as sample and card type, volume, storage, internal patterns, and the effects of hematocrit are crucial to improving the reliability of these results.

Conflict in emergency medicine: A systematic review.

The emergency department (ED) is a demanding and time-pressured environment where doctors must navigate numerous team interactions. Conflicts between health care professionals frequently arise in these settings. We aim to synthesize the individual-, team-, and systemic-level factors that contribute to conflict between clinicians within the ED and explore strategies and opportunities for future research. Online databases PubMed and Web of Science were systematically searched for relevant peer-reviewed journal articles in English with keywords relating to "conflict" and "emergency department," yielding a total of 29 articles. Narrative analysis showed that conflict often occurred during referrals or admissions from ED to inpatient or admitting units. Individual-level contributors to conflict include a lack of trust in ED workup and staff inexperience. Team-level contributors include perceptions of bias between groups, patient complexity, communication errors, and difference in practice. Systems-level contributors include high workload/time pressures, ambiguities around patient responsibility, power imbalances, and workplace culture. Among identified solutions to mitigate conflict are better communication training, standardizing admission guidelines, and improving interdepartmental relationships. In emergency medicine, conflict is common and occurs at multiple levels, reflecting the complex interface of tasks and relationships within ED.

Intellectual Capital and Value of the Firm: A Systematic Literature Review

Intellectual Capital and Value of the Firm: A Systematic Literature Review

A review of two decades of research on sustainable regional and trans-border infrastructure

In spite of the budding interest of researchers, policymakers and practitioners, there are still differing and disjointed conceptualizations of sustainable regional and trans-border infrastructure (SRTBI) as its meadow is still emerging. In an effort to fill this research gap, the resolution of this study was to review and synthesize SRTBI research and to provide directions for future research. The author reviewed peer-reviewed theoretical and empirical journal articles published during the last two decades – from 2003 to 2023. Scopus database was the source of the journal articles collected to conduct this study. Selected keywords from a rigorous review of literature were pooled with Boolean operators and searched. Subsequently, a scrupulous screening procedure with an inclusion and exclusion criteria was adopted to select the relevant articles for the study. The selected journal articles on SRTBI were subsequently synthesized for further acumens. The field of SRTBI is bitty and has advanced in the passage of the last two decades in diverse ways. This study identified core publication vents and papers, key theoretical and methodological approaches and key variables of interest that exist in the SRTBI literature. The findings also suggested a few research themes for future studies. The study can significantly impact academia and organisational research literature, and it can extend conceptual perspectives of implications of resolutions made to adopt a SRTBI. Adding to its theoretical value, the study has significant implications for policy and practise, as it would expand viewpoints on decisions to adopt SRTBI. The study was based on documents retrieved from Scopus and any limitations of the database may have implications for the findings. This inquiry filled a need to review the current state of the SRTBI literature and spelt out research issues that may be addressed by researchers in future.

Correlation of Serum Prolactin and Thyroid Stimulating Hormone Concentration in Infertile Women: A Systematic Review and Meta-Analysis.

Infertility affects millions of people of reproductive age worldwide. Thyroid hormones and prolactin (PRL) affect reproduction and pregnancy; therefore, these two hormones influence fertility. This systematic review and meta-analysis aimed to summarise the strength of the correlation between serum PRL and thyroid stimulating hormone (TSH) in infertile women and to explore selected factors influencing the correlation. We conducted a systematic search of online databases (PubMed, Scopus, ScienceDirect, SAGE and Google Scholar) from inception until March 2021 and a manual search of the bibliographies of the included studies to identify relevant publications. The original research paper describing the correlation between PRL and TSH in reproductive-age women with infertility (primary and secondary) was included. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies. A random effect model was used to estimate the pooled correlations of PRL and TSH, followed by an assessment of heterogeneity and a sensitivity analysis. From a total of 822 relevant articles identified, 11 were eligible and included in this systematic review and meta-analysis. The random effect pooled correlation estimates between PRL and TSH was 0.431 (95% CI: 0.251, 0.582), with substantial heterogeneity between the included studies (I2 = 80%, τ2 = 0.067, P < 0.001). No significant publication bias was observed. Study region, types of infertility, sample size and year of the study did not influence the correlation estimates. Our results highlighted a significant positive moderate correlation between serum PRL and serum TSH in infertile women.

Prosthetic Fitting Concepts after Major Amputation in the Upper Limb - an Overview of Current Possibilities

The upper extremity and particularly the hands are crucial for patients in interacting with their environment, therefore amputations or severe damage with loss of hand function significantly impact their quality of life. In cases where biological reconstruction is not feasible or does not lead to sufficient success, bionic reconstruction plays a key role in patient care. Classical myoelectric prostheses are controlled using two signals derived from surface electrodes in the area of the stump muscles. Prosthesis control, especially in high amputations, is then limited and cumbersome. The surgical technique of Targeted Muscle Reinnervation (TMR) offers an innovative solution: The major arm nerves that have lost their target organs due to amputation are rerouted to muscles in the stump area. This enables the establishment of cognitive control signals that allow significantly improved prosthesis control. A selective literature review on TMR and bionic reconstruction was conducted, incorporating relevant articles and discussing them considering the clinical experience of our research group. Additionally, a clinical case is presented. Bionic reconstruction combined with Targeted Muscle Reinnervation enables intuitive prosthetic control with simultaneous movement of various prosthetic degrees of freedom and the treatment of neuroma and phantom limb pain. Long-term success requires a high level of patient compliance and intensive signal training during the prosthetic rehabilitation phase. Despite technological advances, challenges persist, especially in enhancing signal transmission and integrating natural sensory feedback into bionic prostheses. TMR surgery represents a significant advancement in the bionic care of amputees. Employing selective nerve transfers for signal multiplication and amplification, opens up possibilities for improving myoelectric prosthesis function and thus enhancing patient care. Advances in the area of external prosthetic components, improvements in the skeletal connection due to osseointegration and more fluid signal transmission using wireless, fully implanted electrode systems will lead to significant progress in bionic reconstruction, both in terms of precision of movement and embodiment.