Release Time Research Articles

The welfare effect of release timing of relative performance evaluation under quantity competition and asymmetric costs

AbstractWe examine the welfare effects of the endogenous decision and release timing of weight placed on the rival's profits under relative performance evaluation with quantity competition and asymmetric marginal costs. We find that when the advantaged firm decides and releases the weight as the leader, it always chooses a negative weight on relative performance evaluation, whereas the disadvantaged firm may choose a positive or negative weight depending on the degree of product substitution. Furthermore, we demonstrate that while all firms prefer to release weights early, this situation does not improve social welfare in several economic environments.

Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus.

Locus coeruleus (LC) projections to the hippocampus play a critical role in learning and memory. However, the precise timing of LC-hippocampus communication during learning and which LC-derived neurotransmitters are important for memory formation in the hippocampus are currently unknown. Although the LC is typically thought to modulate neural activity via the release of norepinephrine, several recent studies have suggested that it may also release dopamine into the hippocampus and other cortical regions. In some cases, it appears that dopamine release from LC into the hippocampus may be more important for memory than norepinephrine. Here, we extend these data by characterizing the phasic responses of the LC and its projections to the dorsal hippocampus during trace fear conditioning in mice. We find that the LC and its projections to the hippocampus respond to task-relevant stimuli and that amplifying these responses with optogenetic stimulation can enhance long-term memory formation. We also demonstrate that LC activity increases both norepinephrine and dopamine content in the dorsal hippocampus and that the timing of hippocampal dopamine release during trace fear conditioning is similar to the timing of LC activity. Finally, we show that hippocampal dopamine is important for trace fear memory formation, while norepinephrine is not.

Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

Locus coeruleus (LC) projections to the hippocampus play a critical role in learning and memory. However, the precise timing of LC-hippocampus communication during learning and which LC-derived neurotransmitters are important for memory formation in the hippocampus are currently unknown. Although the LC is typically thought to modulate neural activity via the release of norepinephrine, several recent studies have suggested that it may also release dopamine into the hippocampus and other cortical regions. In some cases, it appears that dopamine release from LC into the hippocampus may be more important for memory than norepinephrine. Here, we extend these data by characterizing the phasic responses of the LC and its projections to the dorsal hippocampus during trace fear conditioning in mice. We find that the LC and its projections to the hippocampus respond to task-relevant stimuli and that amplifying these responses with optogenetic stimulation can enhance long-term memory formation. We also demonstrate that LC activity increases both norepinephrine and dopamine content in the dorsal hippocampus and that the timing of hippocampal dopamine release during trace fear conditioning is similar to the timing of LC activity. Finally, we show that hippocampal dopamine is important for trace fear memory formation, while norepinephrine is not.

Target-oriented robust satisficing models for the single machine scheduling problems with release time

In this paper, we investigate single machine scheduling problems with release times and random processing times, where the release times can be either deterministic or random. The objective is to determine a scheduling sequence that exhibits strong out-of-sample performance. To achieve this, we employ target-oriented robust satisficing models to obtain the scheduling sequence. For the scheduling problem with deterministic release times, we derive an equivalent mixed-integer linear program and an approximate reformulation to address cases involving a large number of jobs. For the scheduling problem with random release times, we first demonstrate the challenges associated with providing an equivalent reformulation. To overcome this intractability, we propose an approximate reformulation based on the linear decision rule. Numerical experiments are conducted to demonstrate the superiority of our solutions through comparisons with several benchmarks. Furthermore, the numerical results demonstrate that a relatively higher target should be chosen if the worst-case performance is valued, otherwise, the decision-maker should set a relatively lower target to obtain better average performance.

Comparative Fitting of Mathematical Models to Carvedilol Release Profiles Obtained from Hypromellose Matrix Tablets.

The mathematical models available in DDSolver were applied to experimental dissolution data obtained by analysing carvedilol release from hypromellose (HPMC)-based matrix tablets. Different carvedilol release profiles were generated by varying a comprehensive selection of fillers and carvedilol release modifiers in the formulation. Model fitting was conducted for the entire relevant dissolution data, as determined by using a paired t-test, and independently for dissolution data up to approximately 60% of carvedilol released. The best models were selected based on the residual sum of squares (RSS) results used as a general measure of goodness of fit, along with the utilization of various criteria for visual assessment of model fit and determination of the acceptability of estimated model parameters indicating burst release or lag time concerning experimental dissolution results and previous research. In addition, a model-dependent analysis of carvedilol release mechanisms was carried out.

Synthesis and characterization of chitosan-based pH-sensitive biofilm: An experimental design approach for release of vitamin B12

Hydrogels because of their unique potentials, such as highwater content and hydrophilicity, are of interest for the controlled release of drug molecules. In the present study, a biofilm was produced using chitosan, a natural polymer. Characterization analyses of the synthesized biofilm were performed using Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis-differential thermal analysis, x-ray diffraction, and scanning electron microscopy-energy dispersive x-ray spectrometry. The analysis results of the film before loading were compared to the analysis made after adding vitamin B12 to the film. The release percentage of vitamin B12 was investigated by using ultraviolet-visible spectrophotometery. The FT-IR bands of vitamin B12 were in the range of 2,800-3,500 cm-1 and 1,000 cm-1-1,750 cm-1. When pH increased from 3 to 7, release of vitamin B12 from the biopolymer increased up to pH 5. While examining the release potential, parameters, such as pH, initial concentration of vitamin B12, release time, and solution volume, were optimized by using response surface methodology. It was determined that with the increase in release time and the initial concentration, pH contributed positively to the release of vitamin B12. The following conditions were determined for release of vitamin B12 from the biofilm: pH: 4.2, initial concentration of vitamin B12: 54.0 mg L-1, the release time: 117 min, and volume of solution: 2.1 mL. The analysis of variance results showed that the determination coefficients for the use of synthesized biofilm in vitamin B12 release were high and R2 =0.9704.

Effect of Antimicrobial Agent Coating on Physicochemical and Biologic Properties of Implant Abutments: A Systematic Review.

To analyze the effectiveness of coating of abutments with antimicrobial agents and their influence on the physicochemical and biologic properties of the coated materials. This work was registered in Open Science Framework (osf.io/6tkcp) and followed the PRISMA protocols. A search of two independent reviewers of articles published up to October 29, 2021, was performed in the Embase, PubMed, Science Direct, and Scopus databases. The databases found a total of 1,474 references. After excluding the duplicates, 1,050 remained. After reading the titles and abstracts and applying the inclusion criteria, 13 articles remained and were read in full. A total of 8 articles were included in this systematic review. Different antimicrobial agents have been used to coat abutments, including graphene oxide, polydopamine, titanium and zirconium nitride, lactoferrin, tetracycline, silver, and doxycycline with varied release times. Titanium-coated silver showed a better antimicrobial agent release time of up to 28 days. Chemical analysis confirmed the presence of antimicrobials on the surface after coating. Different pathogenic microorganisms, such as Streptococcus sanguinis, Streptococcus oralis, and Staphylococcus aureus, were inhibited when in contact with the coated surface. This review showed that there is still no consensus on which is the better antimicrobial agent and which coated materials have the better performance. However, the association of surface coating of abutments with antimicrobials is feasible and can benefit many patients, which can support their clinical use to favor the healing process and prevent infections that can lead to treatment failure with dental implants.

A Review of Robust Machine Scheduling

Robust optimization (RO) has been recognized as an effective means to deal with unanticipated events in highly uncertain and risky environments. This paper systematically reviews two types of emerging RO machine scheduling approaches—robust machine scheduling (R-MS) and distributionally R-MS (DR-MS) methods—which usually offer tractable formulations and analytical results for machine scheduling problems under uncertainty. First, after highlighting the advantages of RO methods over the stochastic approach in terms of tractability and robustness, we use the bibliometric method to analyze the literature related to R-MS/DR-MS problems and classify them from the following aspects: (1) uncertain factors, (2) uncertainty descriptions, (3) robustness criteria, (4) machine environments and (5) solution methods. Second, we discuss the uncertainty descriptions, and the robust feasibility and robust optimality criteria. We further provide a state-of-the-art review of R-MS/DR-MS models in different machine environments and discuss the performance of the R-MS/DR-MS models. Third, we review and discuss the existing exact, approximation, online, and heuristic solution methods for solving R-MS/DR-MS models. Finally, we present future research opportunities in two promising areas: green machine scheduling problems and machine learning-enabled algorithms. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Machine scheduling plays an essential role in industrial and service systems, such as manufacturing, power generation, transportation and medical systems. However, in practice, scheduling systems usually operate in highly uncertain environments due to noisy measurements, prediction errors, and implementation deviations. To ensure robust feasibility and robust optimality, robust machine scheduling (R-MS) and distributionally R-MS (DR-MS) approaches have been recently proposed to hedge against the uncertainties related to processing time, release time, due date, machine breakdown, etc. This paper provides a comprehensive review of the R-MS/DR-MS models and algorithms in different machine environments from the aspects of uncertainty descriptions, robustness criteria and solution methods. This paper further highlights the challenges of R-MS problems and provides promising and valuable research opportunities in terms of problem formulations and algorithm designs.

Determining the Timing of Spore Release by Botryosphaeriaceae Species in Oregon Vineyards.

Botryosphaeria dieback, caused by a group of pathogens in the Botryosphaeriaceae family, is one of the most common grapevine trunk disease complexes (GTDs) found in Oregon vineyards. To understand the period of spores released by Botryosphaeria spp. in Oregon vineyards, four Burkard 7-day recording volumetric spore traps were placed in vineyard blocks in northern and southern Oregon. Each trap was placed near a younger (<10 years) and older (>30 years) block in both regions. Spore traps were deployed at the beginning of December 2019 and continued until March 2021. Between these timeframes, 475 and 477 days of samples were collected from each spore trap in northern and southern Oregon, respectively. DNA extraction was performed from individual day samples and followed by qPCR analysis of Botryosphaeria spores trapped in each tape sample. Weather data such as temperature, precipitation, relative humidity (RH), and wind speed were collected from nearby weather stations. Association between these data and number of spores detected were analyzed using Pearson correlation analysis. In northern Oregon, the detection occurred between December and February, and the first spore detection occurred when cumulative growing degree day (GDD) totaled to 4,357 and 4,351 units (TBase = 0°C, biofix date = January 1) during the first and second seasons, respectively. Similarly, in southern Oregon, the detection occurred between November and January, and the first spore detection occurred when cumulative GDD was 4,405 units during the second season. Hours of continuous RH >86% was significantly associated with number of spores released (P = 0.026; r = 0.42). During the spore detected dates, the RH was >86% for at least 19 consecutive hours. These findings provide an important implication to manage Botryosphaeria dieback by protecting pruning wounds during the most-spore-released periods. Furthermore, the knowledge of weather variables and their possible association with spore detection provides important information towards developing predictive models in future studies.

Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate

This study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-precipitation method was homogenously mixed with the Tween-80 coater under continuous stirring. The successful Tween-80 coating was verified with PXRD analysis and supported by FTIR. No changes in interlayer distance between LDH-FA (at 17.4 and 8.7 Å) and LDH-FA-T80 (at 17.6 and 8.6 Å) were observed in the PXRD pattern. TGA/DTG analysis demonstrated good thermal stability of LDH-FA-T80, with the ability to withstand extreme temperatures up to 460 °C. The association of Tween-80 with LDH-FA progressively sustained the release time of FA in each aqueous solution, with a release time of up to 440 min. For both LDH-FA and LDH-FA-T80, the release of FA is through dissolution and anion exchange release mechanism (regulated by pseudo-second-order kinetic model). The study's findings suggest practical applications of FA in the pharmaceutical industry by implying the retarding effect triggered by Tween-80, offering new insights for the application of CRF to enhance the therapeutic effect of FA.

Synthesis And Ecotoxicological Evaluation of Gelatin‐Urea Delivery System for Biostimulation Purposes

AbstractIn this study, the behavior of slow‐release urea capsules is investigated for bioremediation purposes. The urea capsules (u/PUA/HG) are produced by an emulsion system (O/W) containing a double coating of polyurea (internal) and gelatin hydrogel (external), using for both toluene‐2,4‐diisocyanate (TDI) as a reagent. The slow‐release system are characterized by Fourier transform‐infrared spectroscopy by ATR, optical microscopy, swelling index test (%), and urea release test (%). Eco‐toxicological studies are carried out to evaluate the toxicity of composites using germination (and root growth) of lettuce seeds. Also, preliminary study is conducted based on assessed of the Pseudomonas aeruginosa microbial behavior in the presence of composites. The characterization results indicate the effective coating of the urea granules. However, the FTIR analysis reveals an excess of unreacted TDI in the u/PUA/HG sample. Furthermore, there is an observed inhibition of both root growth and germination that corresponds to the quantity of the sample and TDI used. Notably, there is a notable 70% increase in microbial growth compared to the control group after 48 h. Upon concluding the urea release test spanning 144 h, a significant 43% reduction is observed for u/PUA/HG at 24°C. Additionally, there is a delay of 119 h in the total release time at 36°C, when compared to u/PUA. Collectively, the outcomes of this study strongly suggest the potential of u/PUA/HG as a bio‐stimulant, particularly in its effect on P. aeruginosa growth. These findings highlight its promising application as a bioremediator in the future.

Prediction of power generation output of compressed air energy storage tank based on temperature limitation

The pressure and temperature of the CAES system drop during the power generation process. This generation will be forced to stop when the temperature reaches the metal material limit. To avert the power generation process from stopping due to the temperature dropping too low, it is necessary to monitor and predict the power output of the CAES system in real time. By setting the relevant control operation logic, according to the temperature limit value of the gas canister, the minimum allowable temperature of the gas canister design, and the maximum value of the minimum allowable temperature of the pipe design between the gas canister and the heat exchanger, the minimum allowable temperature of the gas canister is obtained. the residual energy release energy and residual energy release time of the gas storage tank can be calculated by collecting relevant parameters in real time. It is verified by the simulation experiment of the 10 MW CAES system model. By monitoring the changes in parameters such as the temperature of the gas canister during the energy release process, the prediction model can calculate the compressed gas in the gas canister more accurately, and the power generation output can be predicted in the operation of the CASE system. Mastering the residual energy release energy and residual energy release time of the gas canister can arrange the operation mode in advance and improve the reliability of unit operation.

Role of Vitamin E And Selenium as an Anti-Stressant in Translocation of Captive Ungulates

Wild ungulates especially in captivity face high stress in translocation that may cause even mortality. Chemical immobilization is employed to minimize stress by using sedatives. Vitamin E and Selenium may have impact on reducing stress. Objectives: To estimate the impact of Vitamin E and Selenium treatment in translocation of captive ungulates. Methods: The study was carried out while planned translocation of 40 ungulates from different zoological gardens of four districts of Punjab to Safari Zoo, Lahore, Punjab, Pakistan was performed. The animals were divided into two equal groups i.e., A and B. Both groups were anesthetized with combination of Ketamine and Xylazine while Vitamin E and Selenium was also injected in group B after anesthesia. Blood samples were also drawn for hemato-chemical analysis in both groups. The necropsy of the dead animals was also done for internal organs and skeletal muscles examination. Results: In the group A, two chinkaras and two spotted deer were found dead at the time of release. The pale areas, hemorrhages and clotted blood were observed in necropsy. The values of Hemoglobin, Total Erythrocyte Count and Packed Cell Volume were moderately varied from the normal in both groups. The group A had greater lymphocyte count and lower neutrophils while in group B, lymphocyte count was lower, neutrophils were higher and Aspartate transaminase (AST), Alanine transaminase (ALT), and cortisol levels were quite higher than normal. Conclusions: Vitamin E and Selenium has positive impact to reduce stress level in translocation of captive ungulates.

Surface modification of titanium foams for modulated and targeted release of drug-loaded biocompatible hydrogel. Proof of concept

Bone-tissue replacement surgeries usually need medication to mitigate implant rejections or prevent local infections. In this study, a modulated and targeted tetracycline (TC) loaded gelatine type A hydrogel is release from Ti foams as a proof of concept for an innovative and intelligent drug release system. The drugs are released in a localized and controlled manner. The Ti foams fabricated by the space holder technique were surface modified by two different techniques of surface modification, i.e., thermal oxidation and acid etching, to assess their influence on TC release. The characterization carried out after the surface modification indicated that samples modified with acid etching have produced a rougher surface, increasing the diameter of pores (from 500 μm to 700 μm, approximately) due to coalescence of pores. The increase of pore roughness has demonstrated the delaying of the TC release due to the greater adhesion between the surface roughness and the hydrogel. In addition, the increase of pore size improves the possibility to infiltrate high amount of drug-loaded biocompatible hydrogel. Opposite, oxidized surface samples have generated a rutile type TiO2 layer that, because of its hydrophilic nature facilitate the degradation of the hydrogel, and consequently, the TC release from the Ti foams. Therefore, both methods show opposite behaviour, available to increase (acid etching) or decrease (thermal oxidation) the TC release thanks to the different kinetic degradation of hydrogel, as a potential way for drug-release from metallic implants. Thus, while acid-etched samples showed maximum TC release value of 35 wt%, after 120 min, the oxidized samples surpassed the 40 % of TC release after same 120 min of release time treatment.

Fluorocarbon Plasma-Polymerized Layer Increases the Release Time of Silver Ions and the Antibacterial Activity of Silver-Based Coatings.

Silver-based antibacterial coatings limit the spread of hospital-acquired infections. Indeed, the use of silver and silver oxide nanoparticles (Ag and AgO NPs) incorporated in amorphous hydrogenated carbon (a-C:H) as a matrix demonstrates a promising approach to reduce microbial contamination on environmental surfaces. However, its success as an antibacterial coating hinges on the control of Ag+ release. In this sense, if a continuous release is required, an additional barrier is needed to extend the release time of Ag+. Thus, this research investigated the use of a plasma fluoropolymer (CFx) as an additional top layer to elongate Ag+ release and increase the antibacterial activity due to its high hydrophobic nature. Herein, a porous CFx film was deposited on a-C:H containing Ag and AgO NPs using pulsed afterglow low pressure plasma polymerization. The chemical composition, surface wettability and morphology, release profile, and antibacterial activity were analyzed. Overall, the combination of a-C:H:Ag (12.1 at. % of Ag) and CFx film (120.0°, F/C = 0.8) successfully inactivated 88% of E. coli and delayed biofilm formation after 12 h. Thus, using a hybrid approach composed of Ag NPs and a hydrophobic polymeric layer, it was possible to increase the overall antibacterial activity of the coating.

Innovative research methodologies in the EU regulatory framework: an analysis of EMA qualification procedures from a pediatric perspective.

The European Medicines Agency (EMA) offers scientific advice to support the qualification procedure of novel methodologies, such as preclinical and in vitro models, biomarkers, and pharmacometric methods, thereby endorsing their acceptability in medicine research and development (R&D). This aspect is particularly relevant to overcome the scarcity of data and the lack of validated endpoints and biomarkers in research fields characterized by small samples, such as pediatrics. This study aimed to analyze the potential pediatric interest in methodologies qualified as "novel methodologies for medicine development" by the EMA. The positive qualification opinions of novel methodologies for medicine development published on the EMA website between 2008 and 2023 were identified. Multi-level analyses were conducted to investigate data with a hierarchical structure and the effects of cluster-level variables and cluster-level variances and to evaluate their potential pediatric interest, defined as the possibility of using the novel methodology in pediatric R&D and the availability of pediatric data. The duration of the procedure, the type of methodology, the specific disease or disease area addressed, the type of applicant, and the availability of pediatric data at the time of the opinion release were also investigated. Most of the 27 qualifications for novel methodologies issued by the EMA (70%) were potentially of interest to pediatric patients, but only six of them reported pediatric data. The overall duration of qualification procedures with pediatric interest was longer than that of procedures without any pediatric interest (median time: 7 months vs. 3.5 months, respectively; p = 0.082). In parallel, qualification procedures that included pediatric data lasted for a longer period (median time: 8 months vs. 6 months, respectively; p = 0.150). Nephrology and neurology represented the main disease areas (21% and 16%, respectively), while endpoints, biomarkers, and registries represented the main types of innovative methodologies (32%, 26%, and 16%, respectively). Our results underscore the importance of implementing innovative methodologies in regulatory-compliant pediatric research activities. Pediatric-dedicated research infrastructures providing regulatory support and strategic advice during research activities could be crucial to the design of ad hoc pediatric methodologies or to extend and validate them for pediatrics.

Feasibility of micro-organisms in soil bioremediation and dust control

Detrimental impacts of dust caused by mine tailings have yielded to several studies on the efficiency of different soil stabilizers. Bacterial stabilization has been recognized as a reality within recent decades, where bacteria could get adhesion to the grains and stabilize the soil particles. However, these bacteria are prone to be destroyed while exposed to the normal environmental conditions. In this study, the effects of microcapsules containing two types of bacterial freeze-dried spores (B.Subtilis Natto LMG 19457 and B.ESH) have been investigated on the mine tailing stability in terms of two parts. The first part of the study is dedicated to the fabrication of microcapsules within the two bacteria and identification of the characteristics of these microcapsules to set the time of microcapsules break and release in the soil. The urea-formaldehyde microcapsules containing tung oil were synthesized using microencapsulation method and at the following, the bacterial spores of B.Subtilis Natto LMG 19457 and B.ESH which had the high durability and the capability to grow in the silicon oil, were added to the microcapsules. The microcapsules effect on MT specimens and the viability of encapsulated spores were determined. The characteristics of the capsules were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric thermal analysis (TGA). In the second part, wind tunnel tests were conducted to study the effects of microorganism stabilizers on mine tailings. The results indicated that the dust erosion reduced from 16% - using water as a stabilizer- to the 0.2% while using microcapsules containing B.Subtilis Natto LMG 19457 and 0.8% while using microcapsules containing ESH. The results showed the high efficiency of microcapsules containing bacteria in stabilizing the MTs. This phenomenon was proved by SEM imaging in which the voids were bounded significantly while using the bacteria.

Bibliometric Analysis of Historical Block Renewal Research at Home and Abroad based on the Scientific Knowledge Map

The renewal of historical blocks plays an extremely important role in the process of urbanization. However, there are few studies focus on the time distribution of the relevant literature corresponding to the renewal of historical blocks and cannot provide a more cutting-edge opinion conclusion. Therefore, this study aims to explore the law of time distribution in the literature study the renewal of historical blocks. This paper uses the scientific knowledge mapping software CiteSpace to systematically visualize the scientific literature in the field of historical block renewal and its many related fields. To start with, the bibliometric analysis of historical block renewal is carried out. This paper makes a bibliometric analysis of the time distribution, keyword distribution, literature release time, mutation keywords, author density, author network, and other data. This paper finds that the literature in the field of historical district renewal in CSSCI and Peking University core journals has been studied more rapidly in the past decade than in previous years. The increase in the number of papers has increased sharply, and the research hotspots have focused on organic renewal and functional replacement. Among them, micro-renewal, place spirit, and industrial sites are the most concerned frontiers. Based on the above results, this paper summarizes the development trend of the main cutting-edge technologies of the renewal of historical blocks and puts forward relevant suggestions for the development of the renewal field of historical blocks in China.

Effect of adhesive components in experimental fluoride varnish on fluoride release within 30 days in vitro study.

We aimed to determine whether adhesive components could increase the release time of effective fluoride concentration from an experimental fluoride varnish applied to bovine teeth. An experimental fluoride varnish containing 5% sodium fluoride (EX1) was prepared and combined with 35% hydroxyethyl methacrylate (HEMA) (EX2), 5% glutaraldehyde (EX3), or 35% HEMA/5% glutaraldehyde mixture (EX4). Two commercially available fluoride varnishes were used for comparison. Each group was applied to bovine incisors, and the fluoride release and pH were monitored for 30 days. Cell viability analysis, scanning electron microscopy, and energy-dispersive spectroscopy were performed. EX4 released the highest and most effective concentration of fluoride for the longest period and reached neutral pH at the earliest; the release was maintained for up to 30 days without cytotoxicity. In conclusion, EX4 is considered to be the most effective varnish to prevent dental caries.

Jail Characteristics and Availability of Opioid Treatment Services: Results from a Nationally Representative Survey.

The current wave of the opioid epidemic has contributed to a record number of drug-related overdoses and a significant proportion of people who experience opioid use disorder are admitted to local jails. These correctional facilities serve as the principal entry point to the criminal justice system as nearly every person who is taken into custody is admitted to a local detention center. Although jails are recognized as primary intervention points for people who may require treatment for opioid use disorder, services in these facilities remain deficient. The absence of jail-based treatment has become a pressing concern as the number of drug-related deaths in custody continues to rise and the risk of post-release overdose also remains high. The present study draws on the opioid-related module of the 2019 Bureau of Justice Statistics' Census of Jails to assess the relationships between the characteristics of 2588 local detention centers and the availability of treatment services. These specific approaches included screening for opioid use disorder, providing medication to manage withdrawal symptoms, administering medication for opioid use disorder (MOUD), providing overdose reversal medication at the time of release, and linking people with community-based care following release from the detention center. The results demonstrate facilities located in the Northeast, larger jails, those in urban areas, and detention centers with higher turnover rates are significantly more likely to provide a wider variety of opioid treatment services. These findings have important implications for the prioritization of policies and the allocation of resources to support the adoption of opioid treatment services in local jails.