This research aims to present new data regarding the relative sea-level variations and related morpho-evolutive trends of Naples coast since the mid-Holocene, by interpreting several geomorphological and historical elements. The geomorphological analysis, which was applied to the emerged and submerged sector between Chiaia plain and Pizzofalcone promontory, took into account a dataset that is mainly composed of: measurements from direct surveys; bibliographic data from geological studies; historical sources; ancient pictures and maps; high-resolution digital terrain model (DTM) from Lidar; and, geo-acoustic and optical data from marine surveys off Castel dell’ Ovo carried out by using an USV (Unmanned Surface Vehicle). The GIS analysis of those data combined with iconographic researches allowed for reconstructing the high-resolution geomorphological map and three new palaeoenvironmental scenarios of the study area during the Holocene, deriving from the evaluation of the relative sea-level changes and vertical ground movements of volcano-tectonic origin affecting the coastal sector in the same period. In particular, three different relative sea-level stands were identified, dated around 6.5, 4.5, and 2.0 ky BP, respectively at +7, −5, and −3 m MSL, due to the precise mapping of several paleo-shore platforms that were ordered based on the altimetry and dated thanks to archaeological and geological interpretations.