The acoustic attenuation, relative sound pressure levels and the equivalent Nikuradse wall roughness under variable flow conditions in a 600 mm concrete sewer pipe are experimentally investigated. The values of the acoustic attenuation are obtained in the case of airborne sound propagation in the dry pipe. A range of values of the equivalent wall roughness is artificially generated by deploying a periodical array of engineering bricks. A novel method of rapid evaluation of the acoustic attenuation is proposed. The method relies upon sound reflections from the adjacent manholes. The results demonstrate that the acoustic attenuation depends strongly on the value of the equivalent wall roughness. This work can pave the way to the efficient methodology for the in-situ, physical evaluation of the equivalent hydraulic roughness of new and existing sewer networks.