On-board diagnostics (OBD) remote monitoring technology is essential for continuously tracking emissions from heavy-duty diesel vehicles (HDDVs) in operation. However, the dew point protection (DPP) mechanism of nitrous oxides (NOx) sensors frequently results in invalid measurement data, impeding effective NOx emissions monitoring. Current research has yet to offer a practical solution to this challenge. To bridge this gap, a novel machine learning-driven approach has been introduced to correct faulty data. This method focuses on using characteristic data extracted from remote monitoring records to train a NOx concentration prediction model. Consequently, predicted values replace the inaccurate measurements triggered by DPP, enabling self-correction of NOx measurements. To validate the effectiveness of this approach, field tests were conducted on four HDDVs. Among the three compared prediction models, the Random Forest (RF) model demonstrated superior performance on the test dataset, achieving an impressive average R2 value of 0.706, while maintaining low RMSE and MAE values of 0.0335 and 0.0199, respectively (normalized). Post-correction analysis indicated that despite DPP being active for only 10–17% of each month, it accounts for a significant 20–50% of NOx emissions, with a relative error margin of less than 12.3% in our estimation. This research holds pivotal importance in enhancing the quality of remote monitoring data (RMD), thereby enabling seamless and efficient emissions tracking for HDDVs.