Fertilization is one of efforts to increase maize production, and among the commercial fertilizers is compound fertilizer, which contains NPK. Due to varied contents of NPK in such fertilizers, the research was conducted to study effectiveness of fertilizers that contain NPK (1510-20) against growth and production of maize. The research was conducted at irrigated field MK1 (dry season 1) from May to August 2017 at Sidorejo Village, Umbulsari Subdistrict, Jember Regency. The research used hybrid maize of var. P 31, organic fertilizer 2 t/ha, Randomized Block Design (RBD) with 3 replications. There were 8 treatments of combined fertilization, so that there were 24 experimental plots. The treatments included Urea: 250 kg and 350 kg, NPK (15-10-20): 250 kg, 350 kg, 450 kg, and 550 kg. The standards of comparisons were without fertilizer and recommended fertilizer. Size of the experimental plot is 6 m x 6 m. Results of the research showed that the application of 250 kg urea + 250 kg NPK 15-10-20/ha produced the highest production of grains, 10.08 t/ha. It could increase the production for about 1.61 % in comparison with the recommended dose (350 kg urea + 450 kg phonska/ha) and increase 9.20 % in comparison with fertilization that used to be applied by the farmer (400 kg urea + 500 kg Phonska/ha). The highest RAE (Relative Agronomic Effectiveness) above 100 can be achieved by the application of 250 kg Urea + 250 kg NPK (15-10-20)/ha for about 102 %. The application of 250 kg urea + 250 kg NPK 15-10-20/ha has made profit Rp. 24,247,000 or using B/C ratio 1.724 is higher than fertilization using the recommended dose (350 kg/ha urea + 450 kg/ha NPK Phonska), which made profit Rp. 23,811,000 or using B/C ratio 1.714. Based on yield of grains and farming calculation, it is suggested to apply 250 kg urea + 250 kg NPK (15-10-20