Relative Youth Research Articles

Subtrochanteric shortening osteotomy in adult sickle cell disease patients with cemented total hip arthroplasty for hip deformities secondary to childhood osteonecrosis: is healing a challenge?

Hip deformity is frequent after childhood osteonecrosis in patients with sickle cell disease (SCD). When they are adults, they present a challenge as candidates for total hip arthroplasty (THA) because of abnormal bone development, their relative youth, and also because of their disease. Performing subtrochanteric osteotomy associated with THA is technically challenging, and healing of osteotomies has never been reported in this population with frequent osteonecrotic bone, whether using cemented or uncemented arthroplasties. We retrospectively analyzed 59 cemented THA with femoral corrective osteotomies (subtrochanteric shortening and transverse derotational osteotomy) performed on hip deformities between 1984 and 2018 in 59 sickle cell adult patients. The patient's age at the onset of osteonecrosis was an average of 8.4 years (6 to 10 years), and at the time of the THA was 28.6 years (19 to 41 years). All the patients had a minimum followup period of six years. Endocrinopathy was frequently associated to SCD Data and consequences were evaluated on bone union. The mechanical variables, such as the length of the resected femur, limb lengthening, the location of the osteotomy site, the size of the stem bridging the osteotomy, and any complications, were also analyzed. The average length of the resected femoral segment was 38.4mm. The length of the femoral stem (bridging the osteotomy) was average 13cm. The mean osteotomy union time was 10.6 months. Twenty-four osteotomies healed in six months, six in nine months, and 29 in twelve months, while five required bone grafts at nine months. The union time of the osteotomy was average 10.6 months. Complications included four cases of transient nerve palsy, and five intraoperative femur perforations. No statistically significant relationship was found between osteotomy union time and mechanical variables. The severity of endocrinopathy associated with sickle cell disease prolonged the healing time. In three cases, cement leakage into the osteotomy gap occurred without resulting in non-healing. Cemented THA, combined with a subtrochanteric femoral shortening with transverse derotational osteotomy, has a long union time but is effective for adult hip deformities of patients with sickle cell patients.

Community sports as a conduit for police–youth relationships: a scoping review

PurposeThis paper sought to bring together police science and sport-for-development (SFD) with a scoping review of the empirical literature on at-risk youth and police relationship-building in the context of sport interventions.Design/methodology/approachWe conducted a scoping review with a Setting, Perspective, Intervention, Comparison and Evaluation (SPICE) model to systematically examine existing studies on the involvement of police in sports-based youth development programs. A total of 1,247 records were identified, and ten empirical research studies were included in the review.FindingsThe review identifies the critical role of stakeholders, especially coaches and community leaders, in facilitating police–youth contact. Coaches often serve as boundary-spanners, building trust between police officers and at-risk youth. Police involvement in these programs is multifaceted, with officers participating as teammates, leaders or mentors. This participation helps dismantle barriers and foster positive relationships but shows that different roles are associated with different benefits and risk factors. Relatedly, the review highlights potential risks such as the hyper-criminalization of youth, emphasizing the need for program designs that promote equality and collaboration.Originality/valueThis paper provides the first significant steps toward conceptualizing the role of police within sport interventions by integrating community policing and SFD literature. We advocate for interdisciplinary collaboration between police science and SFD scholars to further develop police–youth relationships.

Pain-Related Injustice Appraisals, Sickle Cell Stigma, and Racialized Discrimination in the Youth with Sickle Cell Disease: A Preliminary Investigation.

Despite the fact that perceptions of racialized discrimination, health-related stigma, and pain-related injustice have been associated with worse patient functioning, little is known about their unique relationships in Black youth living with sickle cell disease (SCD). In this study, we (1) examined the prevalence of perceptions of racialized discrimination, perceptions of health-related stigma, and pain-related injustice appraisals and (2) investigated how the aforementioned variables were uniquely related to functioning (i.e., functional disability, depressive, and anxiety symptoms) in Black youth living with SCD. The study sample included 30 non-Hispanic Black or African American youth living with SCD (17 male, 13 female youths). The average age of the sample was approximately 11.3years (SD = 2.73). Zero-order correlations and hierarchical regressions were used to examine and compare the multivariate relationships between perceived racialized discrimination, perceived health-related stigma, and perceived pain-related injustice and outcome variables (functional disability, anxiety symptoms, and depressive symptoms). For functional disability, perceived racialized discrimination and perceived pain-related injustice were significant predictors in the final model (F(3,26) = 11.00, p < .01). For depressive symptoms, health-related stigma trended toward significance (p = .09) as a predictor in the final model (F(2,26) = 6.69, p < .01). For anxiety symptoms, perceived pain-related injustice was the only significant predictor in the final model (F(3,26) = 10.25, p < .001). Results suggest that the youth living with SCD experience and perceive racialized discrimination, health-related stigma, and injustice surrounding their pain experience and these factors are associated with worse outcomes.

Exploring adolescents' and stakeholders' perceptions of online and school-based mental health provision.

Adolescents' engagement with online mental health support (e.g., apps, social media) may affect their engagement with traditional support, including in schools. However, research has typically considered engagement with online- and school-based mental health support separately meaning the mesosystemic interaction between the two is overlooked. Using co-produced exploratory qualitative methods, the present study explored adolescents' and adult stakeholders' perceptions of how and why adolescents engage with school-based and online mental health support, the interaction between these two modalities, and the associated risks and opportunities. A youth advisory board (n=4; Age=18-25) co-created data collection methods, ethics procedures, and data analysis. For the main phase of data collection, 27 adolescents (Age M=15.42, SD=1.58, Range=12-18, Girls=73.1%, White=84.6%) with mental health difficulties who had engaged with online support while at school were recruited from across England. Participants chose to participate in an interview (n=10) or focus group (n=17, 5 groups). In addition, interviews were conducted with 12 adult stakeholders who worked in fields related youth mental health. Data was analysed using template analysis resulting in four themes; (a) Support is abundant, but accessing what you need when you need it is tough, (b) Human connection is vital and can be achieved in diverse ways, (c) Striving for autonomy and control, (d) Navigating credibility and trust across contexts. Different types of support met adolescents' needs in different ways, and each offered relative strengths and weaknesses. Findings highlight how adolescents value autonomy and choice when engaging with support, using multiple different sources of support in complementary and self-directed ways to meet their needs. Several challenges were identified across settings, which could be overcome through increased collaboration. This improved collaboration has potential to improve the quality of support available to adolescents.

A Snapshot of Peer Relationships in Children and Youth: Pre- Versus During COVID-19.

Strong peer relationships are an essential component of a healthy, happy, and long lifetime. Given that there is little understanding of the impact of COVID-19 on peer relationships, this study explored the effects of the COVID waves on peer relationships for clinically referred children and youth while controlling for age, sex, and income. 11,281 children and youth between the ages of 4 and 18 years, who were receiving services from mental health agencies across Ontario from January 2018-March 2022, were assessed using the interRAI ChYMH. Chi-square tests of independence and logistic regression analysis was performed. Overall, as expected, there were significantly fewer peer relationship difficulties during COVID-19 compared to the pre-pandemic period. Despite the general decline of peer issues, individuals between the ages of 8-18, particularly males, were more likely to experience peer relationship difficulties compared to those 4-7 years old. Additionally, children from the lowest income households experienced greater peer relationship difficulties during COVID-19 when compared to those from the highest income households. The findings from this study demonstrate the nuanced changes in social behaviours due to the ongoing pandemic for children and youth and highlight those youth who are most in need of social and behavioural interventions.

Основные научные трактовки взаимосвязей общегражданской идентичности молодежи и национальной безопасности Российской Федерации

The purpose of this article is to consider various scholarly interpretations of the relationship between the nature of political identity of different age groups and ensuring national security in modern Russia. Based on the analysis of relevant segment of domestic scientific discourse, it is concluded that the problem of the relationship between general civic identity of the younger generation and ensuring national security in modern Russia is not singled out as a separate research area or a self-sufficient scientific problem. The author substantiates that this perspective is very important from both theoretical and practical points of view, since the solution of all accumulated problems in Russian society largely depends on the positioning of Russian youth in relation to the state and the main directions of its policy.

Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype.

The endocannabinoid system, which regulates fear- and anxiety-related behaviors, is dysregulated in adults with posttraumatic stress disorder (PTSD), as indicated by higher circulating anandamide (AEA) concentrations. The C385A (rs324420) polymorphism in the fatty acid amide hydrolase (FAAH) gene, which catabolizes AEA, is linked to higher AEA concentrations and greater PTSD symptoms in adults. Given that adolescence is a critical period during which trauma and psychiatric disorders emerge, understanding this relationship in youth is essential. This study examines PTSD symptoms, AEA concentrations, and FAAH genotype in a diverse adolescent sample. This study included 102 Detroit-area adolescents (M ± SD = 13.33 ± 2.21 years, 54.9% female) and their parents/guardians. The sample consisted of 40.2% White Non-Hispanic, 34.3% Black Non-Hispanic, 6.9% White Hispanic, 4.9% Asian/Pacific Islander, and 12.7% Biracial adolescents. Trauma exposure and PTSD symptoms were assessed using the UCLA PTSD Reaction Index for DSM-5. Plasma concentrations of AEA were measured by liquid chromatography-tandem mass spectrometry, and FAAH genotype was determined from saliva samples and high-throughput screening. The majority (90%) of adolescents reported trauma exposure, and 20% met PTSD criteria. Higher AEA concentrations were associated with more severe PTSD symptoms (p = 0.009), especially hyperarousal. The FAAH A-allele (present in 52.5% of participants) was associated with higher AEA concentrations (2.11 ± 0.69 pmol/ml, p = 0.013) and greater PTSD severity (22.65 ± 15.931, p = 0.027), particularly those with the reexperiencing cluster, compared to the CC genotype (1.79 ± 0.66 pmol/ml and 15.87 ±+ 13.043, respectively). Elevated AEA concentrations and the FAAH A-allele were associated with greater PTSD symptom severity in urban adolescents. These findings suggest endocannabinoid dysregulation may play a role in adolescent PTSD, highlighting the need for further research and targeted interventions.

Translating Blackness through youth language learning in the Dominican Republic

AbstractThis article presents findings from a six‐month Language and Social Justice course collaboratively designed with multilingual educators in the Dominican Republic. Teaching and learning processes with Dominican and Haitian youth (ages 18–24) illustrate how opportunities to learn about English and Kreyòl from a transnational perspective can disrupt dominant discourses about youth's relationships with themselves and each other. By intentionally focusing on counternarratives to notions that Dominican youth reject their Blackness and that Dominican and Haitian youth interact in tension rather than solidarity, this study highlights how youth “translate blackness” (García Peña, 2022) through language learning. Drawing from transnational literacy frameworks that engage the cultural and linguistic repertoires of Black youth in relationship with one another (Skerrett &amp; Omogun, 2020; Smith, 2023) and from Black‐centered language pedagogies (Anya, 2017; Clemons, 2021b), I describe how youth negotiate meanings and orientations to Blackness through language and literacy practices.

Disruptive papers – A novel bibliometric tool not yet ready for primetime in pediatric urology

Historically, word of mouth, total citation count, H-index, and expert opinion were some of the primary metrics used to identify the most influential papers. This method is subject to significant bias. The disruption score was initially created with the intent of measuring the degree to which a publication introduces a new idea, is repeatedly referenced and may be used as an additional publication evaluation metric. To use disruptive score, a novel bibliometric index to identify influential papers in pediatric urology. A customized search was executed using PubMed to identify papers from NEJM, JAMA, European Urology, Journal of Urology, Urology, Journal of Pediatric Urology, and Journal of Pediatric Surgery between 1954 to 2022 to identify pediatric urology related publications. Once accrued, all papers collected were run through a validated data set to identify a disruption score, where the 50 most disruptive papers were identified. The disruption score ranged from 1 to -1, with a positive score representing papers that are disruptive (challenge current knowledge), whereas a negative score represents developmental papers (help support previous publications). The 50 most disruptive papers were then cross referenced with the NIH iCite tool to identify how many times the article was cited and then the most disruptive articles and the most cited articles were compared. In total, 12,085 articles were identified and included. The database for analysis of disruption score included articles published from 1954 to 2014, leaving a total of 6544 of the papers for which a disruption score was calculated. Most of the articles identified were published in the Journal of Urology (n=32) and Journal of Pediatric Surgery (n=15). Fourteen of the top 50 papers were published prior to 1980 and 7 after 2000. Of the 35 total articles with iCite data available, only 8 articles had greater than 100 total citations. Many of the most disruptive articles identified did not have a large number of citations, highlighting the need to look beyond citation counts when assessing article importance. While this method was able to highlight some lesser-known articles, it does not appear that these citations are all highly impactful, which may be due to the relative youth of the field. Disruption score provides a new way to assess the impact of publications within the field of pediatric urology. While novel, we feel this metric should be used with caution in pediatric urology at this time.

Making it real: Actioning the mental health strategy with Pacific Island communities.

This paper explores the practical implications of the World Health Organization strategy of focussing on community-based mental health and wellbeing ecosystems in the context of the Pacific Island Countries. It draws on the expertise of the participants of a collaborative workshop held during the Creating Futures conference in 2023 to discuss successes, challenges, barriers, opportunities in the implementation of the framework and to examine potential future actions. Some of the significant factors that make for effective and sustained community-based mental health systems include appropriate central coordination and oversight of community-based services, adequate frameworks for quality assurance, meaningful data collection and sustained long-term funding, as well as a range of workforce factors. Flexible and place-based approaches also need to be considered in effective implementation, moving away from Western diagnostic 'labels' to communication that is effective at the local level. Positive community resources as well as the relative youth of the mental health sector in the Pacific Island Nations are huge opportunities to develop affective and appropriate community mental health systems.

Digital Learning and Work Readiness among Marginalized Women

In the era of information communication and technology, all aspects of human life are influenced by ICT. In general, the aim of this research is to identify the readiness of marginalized youth in relation to the use of ICT (knowledge, attitudes, and preferences) in the workplace. The research was conducted in three marginalized communities in three provinces in Indonesia, namely 1) Kalibaru in North Jakarta, 2) Getasan in Semarang Regency, Central Java, and 3) Sekotong in West Lombok, West Nusa Tenggara. This research applies a quantitative approach by conducting a household survey and a youth survey, and a qualitative approach by conducting a series of focus group discussions. The household survey participants were 220 families, and in the youth survey, the participants were 220 youth aged 18-29 years. Questionnaires are used in household and youth surveys. For FGD, an FGD protocol was developed. The results of this research indicate that youth unemployment is considered an important policy in Indonesia. Certification for internships is important to recognize the qualifications and skills of the employees trained and mentored in the company. In addition, considering the limited number of job opportunities in the market, the intense competition, and the limited skills and education of marginalized young people, it seems important to encourage young people to become entrepreneurs. Data obtained from the field shows that only one-third of the participants in this study had attended vocational courses or training provided by any training provider. One of the reasons is that the distance between where they live and the training location is far, while transportation costs are not covered by the training provider. Apart from that, parents also forbid teenagers, especially girls, from going far outside the village to take part in job training. This study shows that young people understand the existence of differences in gender treatment in the workplace. The difference lies in the position of the worker, the regulations, and the salary/wages given to the worker.Men are expected to have higher positions, heavier work responsibilities, and higher salaries/wages than women. There are also gendered jobs, such as sewing and hairdressing for women, while technical jobs are reserved for men. The causes of this segregation are largely rooted in a patriarchal culture that places men as superior. This research shows that the participants have gadgets to communicate with each other. However, only a few of them use sophisticated gadgets to carry out online trading, which can be caused by a lack of knowledge and skills in digital trading and marketing, as well as online management and supply chains. This means that people have sophisticated gadgets just to communicate on social media and play games just to fill their time. They do not use it for economic activities.

Вертикальні провалені отвори до вулканічних печер на поверхні Марса

Studies of Mars have indicated the presence of caves of volcanic and possibly glacial origin on its surface. During volcanic eruptions, flows of lava flow out. As they cool, they are covered with a hard crust and form lava tubes. After the eruption is over, the lava flows out of the tubes at the lowest point and leaves the cavity. Therefore, lava caves are located on the slopes of volcanoes close to the surface. Sometimes their upper part collapses. A large part of the surface of Mars is covered with volcanic craters and mountain ranges. Dark, rounded spots were found in photographs of one of the volcanic plateaus of Tharsis. Their study showed that they are entrances to volcanic caves. The relative youth of these formations is indicated by the sharp edges of these dips. Lava tubes on Mars appear as straight chains of collapses with flat bottoms and nearly vertical slopes. Such objects should become the object of research by future settlers.

Self-harm, suicidal ideation, depression and peer relationships in transgender and gender diverse adolescents accessing specialist mental health services.

There are an estimated 25 million transgender and gender diverse (TGD) individuals worldwide, with 1.2%-2.7% of this population being under the age of 18. Community studies describe increased rates of mental health difficulties such as depression, self-harm, suicidal ideation and difficulties with peer relationships for TGD youth over cisgender peers. However, comparatively little is known about the mental health symptomatology of TGD youth attending specialist mental health services (CAMHS) in the UK. This cross-sectional study explored data from 170 young people participating in the Beating Adolescent Self-Harm (BASH) trial. Baseline data about self-harm, depression, and impact on daily life was compared for those who identified as TGD (n = 18) with those who identified as cisgender (n = 152). In the transgender group, 18 (100%) scored ≥27 on the MFQ suggesting severe depression and had total scores on the SDQ impact scale of ≥3, in the very high range. In comparison in the cisgender group, 140 (92.1%) scored ≥27 on the MFQ and 103 (67.8%) had total scores on the SDQ impact scale of ≥3. The TGD group reported higher rates of self-harm, poorer peer relationships, less prosocial behaviour and greater interference with friendships and leisure activities and impact in the classroom. Both groups reported similar symptoms of depression. Whilst this exploratory study has limitations, these results suggest that TGD youth attending CAMHS may experience greater mental health problems than their cisgender peers.

Association between endogenous sex hormones and adiposity in youth across a weight status spectrum.

While endogenous sex hormones (e.g., testosterone, estradiol) are important factors regulating adipose tissue distribution, studies evaluating such relationships in youth across a wide weight status spectrum are limited. We performed a cross-sectional analysis of 8-21-year-old youth. Multiple linear regression models were used to evaluate associations between sex hormones and adiposity measures (android/gynoid ratio (A/G), total fat mass (FM), visceral adipose tissue (VAT), waist circumference (WC)) and total lean mass (LM), adjusting for pubertal stage and race/ethnicity, and stratified by sex and weight status. Among 342 youth, the mean age was 13.0 ± 2.8 years old (52.6% female; 38.9% normal weight [NW]; 27.8% overweight/obesity [OW/OB]; 33.3% severe obesity [SO]). Testosterone was positively associated with LM among males with NW (1462 g, 95% CI: 255-2668 g) and OW/OB (3792 g, 95% CI: 1244-6340 g), with A/G and WC among males with NW (0.01, 95% CI: 0-0.2 and 10 mm, 95% CI: 4-16 mm, respectively), and negatively associated with WC among males with SO (-43 mm, -81 to -5 mm). Estradiol was positively associated with A/G, FM, and WC among males with SO, and VAT in females with NW. Our findings showed that sex hormones were associated with adipose tissue deposition in youth across the weight spectrum. Sex hormones (e.g., testosterone, estradiol) are associated with various adiposity measures among male and female children and adolescents across a weight status spectrum. We evaluated associations between sex hormones and various adiposity measures among 8-21-year-olds across a weight status spectrum (normal weight, overweight/class 1 obesity, class 2-3 obesity). We found that estradiol was positively associated with total fat mass, android/gynoid ratio, and waist circumference in males with class 2-3 obesity, and testosterone was positively associated with lean mass in males with normal weight and overweight/class 1 obesity. Sex hormones may influence, or may be influenced by, adiposity in youth.

A Latent Profile Analysis of Religious Parents' Responses to Their Sexual and Gender Diverse Child.

Prior research indicates that religious parents can have negative, positive, or ambivalent responses to their child's sexual orientation and gender identity (SOGI). Yet, to our knowledge no research has quantitatively examined patterns of sexual and gender diverse (SGD) youth's perceptions of their religious parents' responses to their SOGI. Without examining variations in these patterns, we are unable to better understand the experiences of SGD youth with religious parents. In the current paper, we examined patterns of SGD youth's perceptions of their religious parents' SOGI-specific rejection, acceptance, and SOGI change efforts. We also examined if these patterns differed by SGD youth's individual and contextual factors. The analytic sample consisted of online responses from 5,686 SGD youth (Mage = 15.95). We found four distinct profiles: Positive Parental Response, Moderate Negative Parental Response, Low Parental Response, and High Negative Parental Response. The largest profile was the Positive Parental Response, suggesting that many SGD youth perceived positive responses from their religious parents. SGD youth with diverse gender identities and intersecting identities, such as race/ethnicity, were more vulnerable to religious parents' negative responses. Findings have implications for existing resources and programs aimed at strengthening SGD youth's relationship with their religious parents.

Spanish adaptation and validation of the Partner Behaviours ss Social Context (PBSC) self-report

Basic psychological needs theory (Deci &amp; Ryan, 2000) is an interesting approach to understand the dynamics of romantic relations. Having valid and reliable instruments will allow assessment of the romantic relationship from this perspective. The aim of this study is to present the development of a Spanish version of the Partner Behaviours as Social Context (PBSC, Ducat &amp; Zimmer-Gembeck, 2010) scale. Through two studies, the factor structure originally proposed is analyzed, determining scale reliability and validity. The results confirm the six-dimension structure, although with some differences. It can be concluded that the proposed scale is an especially interesting instrument for the study of relationships in Spanish-speaking youth.

A Multigroup Structural Equation Modeling Approach for Analyzing Differences Among Sexually Diverse Youth

ABSTRACT High rates of negative behavioral health outcomes among sexually diverse (SD) youth are consistently documented, but population-level trends obscure within-group differences. Social dynamics intersect in youths’ lives in ways that cannot be accounted for by summing their independent effects. An intersectional perspective is essential to understanding the behavioral health outcomes of SD youth. We performed multigroup structural equation modeling using an SD subset of New Mexico Youth Risk and Resiliency Survey (N = 10,037) respondents to examine the moderating role of supportive adult relationships for lesbian, gay, and bisexual youth across 12 intersecting (sexual orientation by race/ethnicity by sex) identity categories. Standardized estimates show that supportive relationships are associated with moderate reductions in psychological distress among lesbians (β = –0.459 for Native, β = –0.303 for Hispanic, and β = –0.421 for white) and female bisexual youth (β = –0.352 for Native, β = –0.376 for Hispanic, and β = –0.393 for white). Among male youth, supportive relationships are associated with reduced likelihood of substance use for gay (β = –0.330 for Native, β = –0.464 for Latinx and β = –0.591 for white) and bisexual youth (β = –0.442 for Native, β = –0.306 for Latinx and β = –0.290 for white). This study challenges monolithic characterizations of SD youth, illustrating that the health-promotive benefits of support differ based on sexual orientation, race/ethnicity, and sex.

Pharmacogenomics: An Update Review

Pharmacogenomics studies how genetics affects how drugs affect the human body. The terms genomics and pharmacology are the sources of the field's name, which represents the intersection of genetics and medicine. The discovery of the laws of heredity in 1866 marked the beginning of the area of pharmacogenetics (PGx). The FDA has established PGx testing recommendations, so whenever these 250+ drugs are being reviewed, testing should be considered. Physicians in the fields of pain management, mental health, and cardiovascular health are among those who provide PGx recommendations. Antidepressant medications offer several therapeutic options that are similar, which makes them a prime candidate for the use of PGx. It makes sense that pharmaceutical companies are hesitant to use pharmacogenomics in clinical investigations given its relative youth. Clinical trials and pharmacogenomic testing together have many advantages. Finding populations with risk factors unrelated to the medication itself may also be facilitated by pharmacogenetics. Oral anticoagulants and chemotherapy treatment regimens are now recommended based on a patient's pharmacogenetic condition. When it comes to patient dosing, pharmacogenetic techniques are gradually replacing the traditional method of depending solely on trial and error. The present therapeutic application of pharmacogenetics can also be applied to drug research and development.

A transversal cross-sectional study of factors related to HPV vaccination status and cancer screening participation among French women aged 25–40

BackgroundIn 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health authorities wanted to increase Human Papilloma Virus (HPV) vaccination and screening rates. There were still many barriers to these measures among young women, their families, and health professionals and teachers. Between 2014 and 2019, international studies found inconsistent effects of HPV vaccination on UCC screening. In 2022, a survey was conducted among women aged 25 to 40 in the Nord-Pas-de-Calais region to assess participation 1) in HPV vaccination and its barriers, 2) in UCC screening as a function of HPV vaccination status.MethodsData were collected using an anonymous online questionnaire distributed by QR code in 80 general practices randomly selected in the Nord-Pas-de-Calais region between January and June 2022. Results were analyzed bivariately using the Chi2 test, multivariately when numbers allowed, and in age subgroups (sensitivity analysis).Results407 complete questionnaires (for 602 participating women) were analyzed. In our sample, 41% of women aged 25 to 40 in the Nord-Pas-de-Calais region were vaccinated against HPV viruses in 2022. The risk factors for non-vaccination, after multivariable adjustment, were: the periods of eligibility for vaccination in the early days of French vaccination (2007–2012: odds ratio OR = 0.04 [95% CI, 0.02–0.09]; 2012–2017: OR = 0.5 [0.3–0.8]), information received from non-medical sources (OR = 0.3 [0.2–0.6]), and absence of information about vaccination (OR = 0.12 [0.05–0.27]). In our sample, 90% of women were screened for UCC. In bivariate analysis, women at risk of not being screened were those who were youngest, had been vaccinated against HPV, were not heterosexual, lived alone, had gynecological follow-up by their general practitioner, and did not have regular gynecological follow-up. Sensitivity analysis showed that the only risk factor significantly correlated with non-screening regardless of age group was lack of regular gynecological follow-up.ConclusionsParticipation in HPV vaccination and UCC screening is improved by medical education and gynecological follow-up. This multicenter study, limited by the relative youth of vaccination in France, should be repeated after 2037 to assess the possible effect of vaccination on screening.

Data-Driven Reliability Prediction for District Heating Networks

As district heating networks age, current asset management practices, such as those relying on static life expectancies and age- and rule-based approaches, need to be replaced by data-driven asset management. As an alternative to physics-of-failure models that are typically preferred in the literature, this paper explores the application of more accessible traditional and novel machine learning-enabled reliability models for analyzing the reliability of district heating pipes and demonstrates how common data deficiencies can be accommodated by modifying the models’ likelihood expressions. The tested models comprised the Herz, Weibull, and the Neural Weibull Proportional Hazard models. An assessment of these models on data from an actual district heating network in Funen, Denmark showed that the relative youth of the network complicated the validation of the models’ distributional assumptions. However, a comparative evaluation of the models showed that there is a significant benefit in employing data-driven reliability modeling as they enable pipes to be differentiated based on the their working conditions and intrinsic features. Therefore, it is concluded that data-driven reliability models outperform current asset management practices such as age-based vulnerability ranking.