Relationship Of Lipid Profile Research Articles

Evaluation of lipid profile in systemic lupus erythematosus and relation with interleukin-10

Objectives: To detect pattern of dyslipidemia in patients of SLE and clarify the correlation between lipid profile with disease activity, inflammatory factors, and cytokines. Materials and Methods: Blood collected from 65 SLE patients and 30 healthy controls measured Th-17, IL-17, IL-10 by flow cytometer. Statistical analysis: The relationship of lipid profile with various parameters was analyzed and stepwise logistic regression was used to assess the predictors of dyslipidemia. Results: The unique pattern of dyslipidemia in high disease activity was a significant decline in high density lipoprotein (HDL) and apolipoprotein A1 when compared to low disease activity. IL-10 was the strongest predictor for HDL (CI: -0.31 to -0.20, p=0.000). This is the first time a relation of IL-10 with HDL has been determined in SLE patients. Conclusions: IL-10 elevation is associated with decline in HDL. Since IL-10 appears to be a potential modulator of dyslipidemia in SLE, it can serve a new target for lipid metabolism to reduce cardiovascular risk in SLE.

The relationship of lipid profile and blood pressure in men in the European North of Russia

The relationship of lipid profile and blood pressure in men in the European North of Russia

The relationship of lipid profile with severity of disease and mortality in patients with COVID-1.

Serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol may be associated with a poor prognosis in COVID-19 patients. We think it may be essential to understand the role of lipids in the pathophysiology of COVID-19. One hundred eighty-nine patients admitted to the emergency department between 20th January and 20th February 2021 and later decided to be hospitalized to an inpatient clinic or intensive care unit were included in the study. The patients were determined to be hospitalized to the inpatient clinic or intensive care unit according to the Turkish Ministry of Health COVID-19 guidelines. A demographic information form was established for each patient. The primary findings we have obtained were as follows: (1) CRP, PCT, D-Dimer levels were found to be high, while Albumin, TC, HDL-c, and LDL-c levels were found to be low in critical type patients; (2) CRP, PCT, and D-Dimer levels were higher in the patients who were intubated compared to those who were not intubated. Albumin and HDL levels were low; (3) DH was found to have a significantly negative relationship with TC and HDL-c, and (4) Sensitivity of LDL-c in predicting mortality was found as 69 % and specificity as 70 %. It was observed that patients with low LDL-c levels had higher mortality rates. We think that hypocholesterolaemia may be an indicator of the impending danger. Our study examined COVID-19 in terms of lipid metabolism and offers a different perspective on the disease (Tab. 4, Ref. 23). Text in PDF www.elis.sk Keywords: COVID-19, lipid, mortality.

Relationship of Lipid Profile with Wagner Severity Level in Diabetic Feet at General Hospital Dr. M. Djamil Padang

A B S T R A C TIntroduction Diabetic foot is an erosion or injury to the epidermis or the distal soleof the foot and the base of the foot in people with diabetes mellitus (DM). Diabeticfoot is a major cause of limb amputation in non-traumatic cases. Per year, as manyas 2-3% of people with diabetes experience complications of diabetic foot. Theprevalence of DM sufferers with diabetic foot is 20-40% in developing countries. InIndonesia, the prevalence of DM sufferers with diabetic foot is around 15% with 32%mortality rate. One factor plays an important role in predisposing the occurrence ofdiabetic foot is the lipid profile. The aim of this study was to determine the correlationbetween lipid profile and Wagner Severity Level on diabetic foot patients at Dr. M.Djamil Central Public Hospital, Padang in the period of July 2020 to December 2020.Method: This research is an observational analytic study with cross sectionalanalytic design. The research sample of 47 cases was taken by non-probabilitysampling with the consecutive sampling method. This research is an observationalanalytic study with cross sectional analytic design. The research sample of 47 caseswas taken by non-probability sampling with the consecutive sampling method.Result: There were 47 cases that met the inclusion criteria where the 51-60 yearsage group (55.3%) was the largest group in cases of diabetic foot. Of these groups, itwas dominated by female patients, namely 31 patients (66.0%). Meanwhile, the BodyMass Index (BMI) was dominated by the group with BMI <25 kg/m2 with a total of26 patients (55.3%). Diabetic foot patient at Dr. M Djamil Central Public HospitalPadang who underwent amputation was 25 patients (53.2%) where most of them,namely 40 patients (85.1%) had suffered from Diabetes Mellitus for> 5-10 years. Thefindings obtained based on the Wagner Severity Level were that the Wagner grade 3-5 (heavy) group consisted of 24 people (51.1%) and Wagner 1-2 (mild) as many as 23people (48.9%). The results of the bivariate test between lipid profile levels withWagner Severity Level in diabetic foot patients showed a significant correlation asindicated by a p value <0.05. Conclusion: Wagner Severity Level which is gettinghigher in diabetic foot patients shows low HDL levels, high LDL levels and high levelsof triglycerides in blood plasma.

Relationship between Serum Uric Acid and Lipid Profiles in Thai Adults

Although the link between serum uric acid, including hyperuricemia and metabolic syndrome had beenreported, the relationship of lipid profiles with serum uric acid remains not comprehensively assessed inThai adults. This current study was performed to examine the relation between serum uric acid and lipidprofiles in Thai adults. A total of 192 blood samples were collected from Thai adults aged 20 years and over(men, n = 67 and women, n = 125). We analyzed serum uric acid levels and serum lipid profiles, includingserum total cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein. Multiple linearregression analysis was used to evaluate the relationship between serum uric acid and lipid profiles. Ourresults found that triglycerides and total cholesterol was linearly related with serum uric acid levels (0.404,95% CI, 0.578, 95% CI 0.164-0.993, respectively). Meanwhile an inverse relation was observed betweenserum uric acid levels and high-density lipoprotein (-0.042, 95% CI -0.015 - -0.067).This study suggested that triglycerides, total cholesterol and obesity had a significant linear association withserum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated.Theearly prevention of obesity and dyslipidemia can reduce the incidence of associated hyperuricemia and goutamong Thai adults

GW27-e0958 Lipid profiles and myocardial injury in patients undergoing percutaneous coronary intervention: a systematic review

percutaneous coronary intervention (PCI) is one of the dominant methods for revascularization in patient with coronary artery disease (CAD), which accompanied with high incidence of periprocedural myocardial injury (PMI). However, the relationship of lipid profiles with PMI in patients after PCI was

Relationship of Lipid Profile and Serum Ferritin levels with Acute Myocardial Infarction.

National Health and Nutrition Examination Survey (NHANES III), 1988-1994, first time reported a significant, positive association in iron storage and heart disease risk. Thereafter several researchers have found an association between iron overload, serum ferritin (SF) and MI. No such Indian study was available in the literature and so we decided to find out the relation of lipid profile and Serum Ferritin with myocardial infarction (MI). Fifty indian patients of AMI (study group) and fifty indian healthy volunteers (control group) were included for the present study. Lipid profile including TC, HDL-c, LDL-c, VLDL-c & TG and SF levels were estimated in all subjects. Mean ± SD of TC level was 250.64 ± 25.61, of HDL-c was 36.52 ± 2.86, of LDL-c was 165.69 ± 26.80, of VLDL-c was 42.35 ± 8.53 and of TG was 211.83 ± 42.65 in study group while these values were 174.46±47.68, 43.2±12.52, 98.37±41.13, 32.88±21.45 and 164.42±107.29 respectively in control group. All the parameters were found not only raised in patients of acute myocardial infarction (AMI) but were also statistically significant when compared with control group (p=<0.01). Mean ± SD of SF levels was 268.43±30.17 ng/ml in study group and 110.96±56.5 ng/ml in control group; this level was found not only raised in patients of AMI but were also statistically significant when compared with control group (p=<0.01). TC, LDL-c, VLDL-c, TG and SF levels were raised in patients of AMI and found to be statistically significant; while HDL-c levels were reduced in such patients and is also statistically significant. It can be concluded that there exists an association in lipid profile and SF with AMI therefore dyslipidemia and raised SF levels are the features of AMI.

EFFECT OF LIPID PROFILE ON PROGNOSIS IN THE PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS

BackgroundThe patients with Amyotrophic lateral sclerosis (ALS) are particularly predisposed to malnutrition for a variety of reasons which include dysphagia, fear of choking and aspiration, inability to feed themselves and...

The relationship of lipid profile and menstrual cycle with acne vulgaris

Objective The aim of this study was to find lipid profile and hormone levels in patients with severe acne vulgaris and to correlate lipid profile with hormone levels. Design and methods Prospective study was performed in the 60 patients of severe acne vulgaris. Lipid profile and serum testosterone, estrogen, and progesterone levels were measured in three consecutive menstrual cycles during luteal phase (19th to 21st day). Their results were compared with a group of 60 age-matched healthy controls. Results Total cholesterol (TC), LDL-C, testosterone, and progesterone levels were higher in patients. Estrogen and HDL-C levels were decreased in patients. Positive correlation was found between testosterone and TC and LDL-C. Estrogen levels were positively correlated with VLDL-C, triglyceride levels, and HDL-C and negatively correlated with TC and LDL-C. Conclusions These abnormalities must be considered in the pathogenesis of the disease and must be taken into account for the treatment of patients of acne.

The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data

Lipophilic molecules, like chlorpyrifos (CPF), present a special problem for interpretation of biomonitoring data because both the environmental dose of CPF and the physiological (pregnancy, diet, etc.) or pathological levels of blood lipids will affect the concentrations of CPF measured in blood. The objective of this study was to investigate the distribution of CPF between plasma and tissues when lipid levels are altered in late pregnancy. CPF was sequestered more in the low-density lipid fraction of the blood during the late stages of gestation in the rat and returned to nonpregnant patterns in the dam after birth. Plasma partitioning of CPF increased with increases in plasma lipid levels and the increased partitioning of CPF into plasma lipids resulted in less CPF in other tissue compartments. Gavage dosing with corn oil also increased plasma lipids that led to a moderate increase of CPF partitioning into the plasma. To mechanistically investigate the potential pharmacokinetic effects of blood lipid changes, an existing CPF physiologically based pharmacokinetic/pharmacodynamic model for rats and humans was modified to account for altered lipid-tissue partition coefficients and for major physiological and biochemical changes of pregnancy. The model indicated that plasma CPF levels are expected to be proportional to the well-known changes in plasma lipids during gestation. There is a rapidly growing literature on the relationship of lipid profiles with different disease conditions and on birth outcomes. Increased blood concentrations of lipophilic chemicals like CPF may point to altered lipid status, as well as possibly higher levels of exposure. Thus, proper interpretation of blood biomonitoring data of lipophilic chemicals requires a careful consideration of blood lipids.

2P-0346 Relationship of lipid profile and gene polymorphism related to lipid metabolism in Japanese

2P-0346 Relationship of lipid profile and gene polymorphism related to lipid metabolism in Japanese