Relationship Of Body Mass Index Research Articles

Relationship of body mass index and kidney outcomes in patients with primary glomerulonephritis: A systematic review and meta-analysis.

Primary glomerulonephritis, is a major contributor to the development of chronic kidney disease and end-stage renal disease. Previous studies on the relationship between overweight/obesity with primary glomerulonephritis in the chronic kidney disease was inconsistent. This study aimed to systematically review and meta-analyze the relationship between body mass index and adverse kidney outcomes in patients with primary glomerulonephritis. PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure were searched. Patients were divided into an overweight/obesity group (group O) and a non-overweight/obesity group (group N) according to their body mass index values. Twenty-six studies with 11,038 patients were selected. Patients in group O had deteriorated baseline characteristics, including worse baseline estimated glomerular filtration rate (weighted mean differences [WMD] = -5.99), higher Scr (WMD = 7.34), uric acid (WMD = 47.53), 24-hour proteinuria (WMD = 0.40), and a higher prevalence rate of hypertension (odds ratio, OR = 2.70) and diabetes mellitus (OR = 2.644). On the histopathologic level, patients in group O had a significantly lower total glomerular number (WMD = -2.30); however, no difference was observed in mesangial cell proliferation, endocapillary hypercellularity, crescents, sclerosis, and tubular atrophy/interstitial fibrosis between the 2 groups. The incidence of adverse renal outcomes in the 2 groups was similar (OR = 0.96). The meta-analysis of hazard ratios from Cox regressions indicated a strong association between overweight/obesity and poor renal outcomes in glomerulonephritis (HR = 1.17). Overweight/obesity glomerulonephritis patients had remarkably poor baseline clinicopathological characteristics. Being overweight or obesity would likely impact the progression of primary glomerulonephritis but not serious enough to contribute to significant poor renal outcomes, which could be prevented by aggressive therapy.

The Cross-Sectional Relation of Body Mass Index to Adiposity among 8- to 19-Year-Olds within Several Races and Ethnicities

To assess the screening ability of a high body mass index (BMI) for high adiposity among 8- to 19-year-olds. This cross-sectional study included 6454 National Health and Nutrition Survey participants from 2011 through 2018. Fat and lean mass were measured with dual-energy X-ray absorptiometry (DXA). We expressed adiposity as fat mass index (FMI, kg ÷ m2) and %fat. Based on the Centers for Disease Control and Prevention 95th percentile, a high BMI correctly classified a high FMI for about 95% of participants in each racial and ethnic group. About 81% (Blacks) to 90% (Hispanics) of participants with a high BMI also had a high FMI. Further, children with a high BMI were 17 (Hispanics) to 46 (Blacks) times more likely to have a high FMI than those with a "normal" BMI. The screening ability of high BMI for high %fat was weaker because levels of %fat are influenced by both fat mass (numerator) and lean mass (denominator). Despite differences in body composition, a high BMI is a very good screening tool for identifying high FMI not only among White 8- to 19-year-olds but also among Asians, Blacks, and Hispanics. Compared with %fat, FMI is likely a better adiposity metric among children and adolescents.

Relationship of body mass index on the radiation exposure of patient in diagnostic coronary angiogram through radial route by dose area product

Relationship of body mass index on the radiation exposure of patient in diagnostic coronary angiogram through radial route by dose area product

Relationship of body mass index and plasma imatinib levels in CML patients and mitigation of clinical impact using PK-guided dosing strategy.

e18522 Background: Imatinib is a mainstay of treatment for patients with chronic myeloid lymphoma (CML). Exposure-response relationships have been demonstrated and trough levels between 800 and 1000 ng/ml are usually associated with Major Molecular Response (MMR), prolonged survival and acceptable safety. The extent to which body mass index (BMI) might influence drug pharmacokinetics (PK) and clinical outcome remains to be investigated. Methods: Therapeutic drug monitoring was performed in 60 adult patients (56 years, M33/27F) starting imatinib (400 mg QD) for CML, and baseline deviation from target Cmin was used to subsequently adjust dosing using Monolix software. Baseline BMI was calculated and collected along with other patient characteristics and comedications likely to alter imatinib PK. Response (MMR at 3 months) and drug-related toxicity (CTCAE grading) were recorded. Patients were divided into three subgroups: BMI<18.5; 18.5<BMI<24.5, and BMI>24.5. The association between BMI and trough imatinib levels at baseline, further differences in toxic events and response rate between cohorts, as well as differences in dosing after PK-guided dose adjustment, were all tested using appropriate statistical analysis. Results: Mean imatinib trough levels at baseline were 1172 (754-4737), 870 (276-1767) and 820 (334-2217) ng/ml for patients with BMI<18.5, 18.5<BMI<24.5 and BMI>24.5, respectively. Patients with BMI<18.5 were statistically overexposed (p<0.01, ANOVA). Conversely, there was a trend towards lower exposure in patients with BMI>24.5, but this was not statistically significant. Multivariate analysis confirmed that low BMI was an independent factor for overexposure with imatinib. After PK-guided dosing, a statistically significant difference in dosing after correction was observed, as overexposed patients had their dose reduced to an average of 330 mg QD, whereas underexposed patients had their dose increased to an average of 500 mg QD (p<0.01, paired t-test). Consequently, when comparing in the three different cohorts the incidence of both response and toxic events, no difference was observed among patients (p=0.33 and p=0.911 for efficacy and toxicity respectively, Chi-2 test). Conclusions: Low BMI (<18.5) puts patients at risk of significant overexposure to imatinib, whereas there is a trend towards lower exposure in patients with high BMI (>24.5). This could potentially lead to either increased toxicity or lack of efficacy is no adjustment in dosing is performed. Here, TDM with subsequent adaptive dosing helps to correct the dose according to the initial deviation from target, thus smoothing the clinical impact of the differences in exposure observed at the start of treatment.

Cervical length screening among low-risk women; relationship of body mass index on cervical length and risk of preterm birth

BackgroundPreterm birth (PTB) contributes to nearly 11% of all deliveries in the world. The majority of spontaneous preterm birth (sPTB) remains unexplained. Risk factors include abnormal body mass index (BMI), short cervical length, comorbidities and many more. However, there is limited study on the association between body mass index, cervical length and preterm birth in Malaysia among low-risk women. Hence, we aim to examine the relationship between body mass index, cervical length and the risk of spontaneous preterm birth.MethodIn this prospective cohort study, pregnant women between 16 and 24 weeks who fulfilled the criteria were recruited. Women with history of preterm birth were excluded. Demographic and clinical data (age, BMI, ethnicity, education level and parity) were obtained. Cervical length was measured using transvaginal scan. Patients were then followed up till delivery to determine their delivery gestation and outcome of delivery.ResultsOut of 153 women who participated in this study, 146 women had cervical length of more than 30 mm, six had cervical length between 25 mm and 30 mm and one had cervical length of 24 mm. There were nine (9) cases of sPTB, with all of them being late preterm with normal midtrimester cervical length. Almost half of them (44%) were overweight/obese. A significant association was found between age, cervical length, and parity compared to BMI. Nevertheless, no significant association was seen between the BMI and risk of sPTB.ConclusionThis study demonstrates a higher BMI is associated with longer cervical length, but it is not necessarily protective against sPTB. Hence, we concluded there is a limited role in cervical length screening among low-risk women regardless of their BMI in predicting sPTB.

Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization.

Mammographic density phenotypes, adjusted for age and body mass index (BMI), are strong predictors of breast cancer risk. BMI is associated with mammographic density measures, but the role of circulating sex hormone concentrations is less clear. We investigated the relationship between BMI, circulating sex hormone concentrations, and mammographic density phenotypes using Mendelian randomization (MR). We applied two-sample MR approaches to assess the association between genetically predicted circulating concentrations of sex hormones [estradiol, testosterone, sex hormone-binding globulin (SHBG)], BMI, and mammographic density phenotypes (dense and non-dense area). We created instrumental variables from large European ancestry-based genome-wide association studies and applied estimates to mammographic density phenotypes in up to 14,000 women of European ancestry. We performed analyses overall and by menopausal status. Genetically predicted BMI was positively associated with non-dense area (IVW: β = 1.79; 95% CI = 1.58, 2.00; p = 9.57 × 10-63) and inversely associated with dense area (IVW: β = - 0.37; 95% CI = - 0.51,- 0.23; p = 4.7 × 10-7). We observed weak evidence for an association of circulating sex hormone concentrations with mammographic density phenotypes, specifically inverse associations between genetically predicted testosterone concentration and dense area (β = - 0.22; 95% CI = - 0.38, - 0.053; p = 0.009) and between genetically predicted estradiol concentration and non-dense area (β = - 3.32; 95% CI = - 5.83, - 0.82; p = 0.009), although results were not consistent across a range of MR approaches. Our findings support a positive causal association between BMI and mammographic non-dense area and an inverse association between BMI and dense area. Evidence was weaker and inconsistent for a causal effect of circulating sex hormone concentrations on mammographic density phenotypes. Based on our findings, associations between circulating sex hormone concentrations and mammographic density phenotypes are weak at best.

Relationship of Body Mass Index on Patient-Reported Outcomes After Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial.

Body mass index is known to contribute to outcomes for patients with knee osteoarthritis. Furthermore, body mass index influences the protein expression of orthobiologic treatments like platelet-rich plasma and microfragmented adipose tissue. We performed a secondary analysis of the association of body mass index with patient-reported outcomes for patients with knee osteoarthritis who received either platelet-rich plasma or microfragmented adipose tissue injections. Seventy-one patients with knee osteoarthritis were randomized to receive a single ultrasound-guided injection of platelet-rich plasma or microfragmented adipose tissue. Platelet-rich plasma was created from 180 cc of anticoagulated blood and processed using a double-spin, buffy-coat concentration system. Microfragmented adipose tissue was created using autologous lipoaspirate that was processed according to minimal manipulation guidelines. Patient-reported outcomes and osteoarthritis outcome scores (Knee Osteoarthritis and injury Outcome Score) were tracked for 12 mos. Forty-nine patients (platelet-rich plasma = 23, microfragmented adipose tissue = 26) completed 12-mo follow-up. Knee Osteoarthritis and injury Outcome Score quality of life and activity of daily living subscores were inversely correlated (both P < 0.05) with body mass index in the microfragmented adipose tissue but not platelet-rich plasmagroup. Knee Osteoarthritis and injury Outcome Score pain and sport subscores showed a trend toward inverse correlation with body mass index in the microfragmented adipose tissue group ( P = 0.07 and P = 0.06, respectively), but not platelet-rich plasma. Body mass index was negatively associated with patient-reported outcomes in patients who received microfragmented adipose tissue injections for knee osteoarthritis, but not for patients receiving platelet-rich plasma.

Interactive Relations of Body Mass Index, Cardiorespiratory Fitness, and Sex to Cognitive Function in Older Adults.

The course of cognitive aging is influenced by multiple health factors. This cross-sectional study investigated the interactive relations between body mass index (BMI), maximum oxygen consumption (VO2max), and sex on neuropsychological outcomes in community-dwelling predominantly older adults. Participants were 164 healthy adults [M (SD) = 64.6 (12.5) years, 56% men, 87% white] who participated in an investigation of cardiovascular risk factors and brain health. Multivariable regression analysis, adjusted for age, education, ethnicity, smoking, alcohol consumption, and depression, examined the interactive relations of BMI, VO2max, and sex to multiple neuropsychological outcomes. Significant BMI*VO2max*sex interactions for Grooved Pegboard dominant (p= .019) and nondominant (p= .005) hands revealed that men with lower VO2max (l/min) displayed worse performance with each hand as BMI increased (p's < .02). A significant BMI*sex interaction for Logical Memory-Delayed Recall (p= .036) (after adjustment for blood glucose) showed that men, but not women, with higher BMI demonstrated worse performance (p= .036). Lastly, significant main effects indicated that lower VO2max was related to poorer logical memory, and higher BMI was associated with poorer Trail Making B and Stroop interference scores (p's < .05). Among men, higher cardiorespiratory fitness may protect against the negative impact of greater BMI on manual dexterity and motor speed, making VO2max a target for intervention. Higher BMI is further associated with poorer executive function and verbal memory (in men), and lower VO2max is associated with poorer verbal memory.

The relationship of body mass index, diet, and eating pattern with orthorexia nervosa amongst medical students

Orthorexia nervosa (ON) is an obsessive behavior towards healthy food with more importance on the quality than the quantity of food. Medical students tend to experience ON. The prevalence of ON in the Faculty of Medicine, University of Tanjungpura (FK UNTAN) is around 56.1%. The study is conducted to assess the relationship between body mass index (BMI), diet, and eating patterns with ON indications for students of the Medical Study Program, FK UNTAN. This study uses mixed method (quantitativequalitative), for 66 students (2020 and 2021 batches) through proportionate stratified sampling and 10 students with low and high ON indications with the convenience methode. Analysis used Spearman's rho correlation test and contingency coefficient; qualitative analysis used descriptive inductive method. Bivariate analysis showed p&amp;gt;0.005 for BMI (p=0.139, diet (p=0.105), and the results were invalid for dietary pattern. Qualitative analysis shows people with ON can be influenced by social media which is characterized by their habit of seeking inspiration for healthy eating behaviors. There is no statistically significant relationship between BMI, diet, and eating patterns with ON but still found in FK students because of their knowledge related to nutrition, health and the desire to avoid illness.

Relative Body Mass Index Improves the BMI Percentile Performance for Detection and Monitoring of Excess Adiposity in Adolescents.

Obesity is defined as excess adipose tissue; however, commonly used methods may under-detect adiposity in adolescents. This study compared the performance of body mass index percentile (BMI%) and relative body mass index (RBMI) in identifying excess body fat percentage (BF%) and estimated RBMI cut points to better stratify severity of adiposity. In 567 adolescents ages 11-19 year, BF% measured by DXA was used to compare BMI% and RBMI performance at different degrees of adiposity. RBMI cut points for adiposity detection were derived via ROC curve analysis. BF% was strongly correlated with BMI% (r = 0.889, p < 0.001) and RBMI (r = 0.901, p < 0.001). However, RBMI exhibited less dispersion and better discriminated the relationship with BF% independent of age, race, and gender. Both BMI% and RBMI performed similarly for detecting high BF% (≥25 BF% in males; ≥30 BF% in females). Nonetheless, the relationship of BMI% with BF% was diminished among leaner adolescents. RBMI detected overweight in 21.3% more females and 14.2% more males. RBMI improved the detection of excess adiposity in individuals otherwise classified as having normal weight or overweight by BMI%. RBMI is a valuable and accessible tool for earlier detection, intervention, and effective follow-up of excess adiposity in youth at higher risk for complications.

Relationship of body mass index and perceived stress in medical undergraduates

Background: Young adults are prone to stress due to various life events. Managing these stressors can be difficult for them making them, cope with these through behavioral changes, the most common being unhealthy and irregular eating habits and a lack of physical activities. Aims and Objectives: This study aims to find the correlation between body mass index (BMI) and perceived stress among young adults. Any gender differences are also evaluated. Materials and Methods: Out of the 300 1st year medical students enrolled, height and weight for BMI and perceived stress scale-10 (PSS-10) scores were obtained for 228 participants as a one-time reading for every participant. Then, the relationship between these values of BMI and PSS was evaluated. Results: Out of the analyzed participants, 46.1% were in the normal BMI category, with 15.8% being underweight. Out of the 38.1% of participants with an above-normal BMI, 2/3rd were found to be obese. Moderate stress was seen in 75% of participants. We found a weak negative correlation between BMI and stress (significant at 0.05). Conclusion: The majority of the youth experience stress at moderate level, which is concerning for society as they indulge in stress eating to cope but end up being obese and more prone to metabolic diseases, thus entering a vicious cycle of obesity, disease, and stress. Hence, activities such as exercise, meditation, and others must be included in daily life to balance physical and mental health.

Body mass index, socioeconomical status, and physical activity among school-going children: A correlational study

Abstract: BACKGROUND AND OBJECTIVE: Childhood obesity is currently one of the major concerns in the pediatric field. Socioeconomic status (SES) and physical activity (PA) are key factors in achieving efficient weight status and help them to prevent obesity in the future. Hence, the present study was undertaken to find out the relationship of body mass index (BMI), SES, and PA among school children. METHODOLOGY: A correlational study was carried out on randomly selected 120 children studying in the 6th, 7th, and 8th standards from two different schools in Surat city. The underweight, healthy weight, and overweight–obesity status were based on BMI percentiles for age and sex. SES was assessed using the Kuppuswamy scale based on parameters such as the head of the family’s educational status, occupational status, and overall aggregate income of the whole family. PA during the previous 7 days was assessed using the Gujarati version of the Physical Activity Questionnaire for Children (PAQ-C [G]). Spearman’s correlation test was applied to find out the correlation of BMI, SES and PA among all the students. RESULTS: Overall, boys have higher PAQ-C scores as compared to girls. Inadequate PA was noted among all children. Results of the present study showed that there was a statistically significant weak positive correlation of SES with BMI (r = 0.34, P &lt; 0.05), a statistically significant moderate positive correlation of SES with PA (r = 0.65, P &lt; 0.05) but a statistically significant moderate negative correlation was found for BMI and PA (r = −0.46, P &lt; 0.05). CONCLUSION: The study concludes a significant relationship between BMI, SES and PA among school children.

Pediatric obesity and development of the penis and testis.

Pediatric obesity is increasing in many countries as socioeconomic status improves and the consumption of high calorie food increases. Thus, effect of obesity on genital development is an important topic. This study aimed to determine relationships of body mass index (BMI) with penile parameters and testicular volume in pediatric patients without penile or testicular abnormalities. Data from 1,499 male pediatric patients from our center were analyzed. Patients with penile or testicular abnormalities were excluded. Their age ranged from 2 to 18 years. These patients were divided into two groups based on their BMI: normal BMI (5th-85th percentile) and high BMI (≥85th percentile). Factors used in analysis included age, anthropometric indicators, baseline penile length (BPL), stretched penile length (SPL), penile circumference (PC), and mean testicular volume. These same parameters were analyzed for different age groups. Pediatric patients with normal BMI showed longer BPL and SPL than patients with high BMI (p<0.05). However, PC and mean testicular volumes showed no significant difference between the two groups. BPL was significantly longer in the normal BMI group starting at ten years of age. SPL was significantly longer in the normal BMI group starting at eleven years of age. Our study confirms that having a higher BMI during childhood has a negative effect on penile length. However, there was no significant relationship between BMI and PC or testicular volume.

Association of Body Mass Index with Peripheral Vascular Resistance

Objectives: To determine the relationship of body mass index (BMI) with peripheral circulation in healthy adults. Methodology: This cross-sectional study was carried out at Jamshoro's Liaquat University of Medical and Health Sciences' Physiology Department. The study lasted one year (January to December 2018). One hundred and eighty healthy persons under the age of forty were chosen, including males and females. After calculating the BMI, to determine the peripheral circulation, arterial blood pressure and heart rate (pulse rate) were recorded. Data was analyzed using IBM SPSS version 23.0. Results: A total of one hundred eighty (180) people took part in the study, 94 (52.2%) of whom were men and 86 (47.8%) of whom were women. Participants in the study had an average age of 21.83 5.88 years. The average person weighed 66.12 kg and was 2.85 m tall. Their average body mass index was 25.10±6.55. The pulse rate (beats/minute) in underweight, normal, overweight, and obese were 73.85±6.17, 73.56±6.04, 76.66±6.72, and 78.85±6.85, respectively (p&lt;0.01). The mean arterial pressures in underweight, normal weight, overweight, and obese were 87.08±6.70, 85.72±8.15, 91.20±6.57 and 94.59±8.14mmHg respectively (p&lt;0.01) Mean pulse pressure in BMI groups mentioned above were also statistically significant (p&lt;0.01), i.e., 36.32±6.43, 39.12±8.12, 40.33±6.78 and 43.49±6.67mmHg respectively. Similarly, systolic BP (mmHg) in underweight, normal weight, overweight, and obese were 111.32±9.31, 113.17±10.41, 120.86±9.23 and 127.23±10.77 respectively (p&lt;0.01). Conclusion: Peripheral vascular resistance varies in accordance with body mass index, but no variation is noted on the basis of gender. In the present study, mean systolic and diastolic BP were significantly different on the basis of difference in BMI.

The effect of body mass index and waist circumference on selected important seminal parameters

A cross sectional study was carried out in a fertility clinic of Sri Lanka in 2018 to find the relationship of body mass index and waist circumference with seminal parameters such as volume, count, motility and morphology of the male with fertility issues (n=105). The male infertility which can cause psychosocial issues, is rising in the modern society. Most of the etiologies of male infertility are unknown and could be biological in origin. Thus, the study was launched to achieve the target up to a certain extent. Every male who visited the clinic for fertility issues was personally evaluated on consent to gather the anthropometric and demographic data. Further, the semen samples of them were also collected for semen analysis. The effect of obesity (BMI and waist circumference wise) on each seminal parameter was tested separately with two statistical tests such as Spearman correlation and Wilcoxon signed rank test and found to have no significant effect from either BMI or waist circumference hence obesity on seminal parameters such as count, volume motility and morphology. Perhaps this could be due to finding of a smaller number of individuals who were in obese and extreme obese situations.

The relation of body mass index and total symptom burden in female oncologic patients

Objectives: Examine the relationship between obesity and symptom burden (SB) among female oncologic patients evaluated in cancer rehabilitation (CR) clinics. Secondary aims included evaluation of the relationship between obesity and SB among race, types of cancer, comorbid conditions and differences in symptom severity on the Edmonton Symptom Assessment Scale (ESAS) questionnaire across body mass index. Background: Obesity is a risk factor for some types of breast and gynecologic cancers. Studies have shown an increased risk for pain persistence and higher symptom severity experienced by obese female patients who undergo oncologic treatments. The severity of symptom burden (SB), however, has not been studied in obese oncologic patients in the rehabilitation medicine setting. Methods: Retrospective chart review study in CR clinics, single institution. All the medical records of female patients (n = 61) who completed ESAS on initial evaluation in CR clinics were evaluated, from August 2020 to January 2022. Results: Obese female patients reported increased SB based on the ESAS questionnaire, specifically three symptom domains: pain, drowsiness, and spiritual distress. Conclusions: Nutrition counseling and lifestyle modifications in CR clinics may positively impact SB.

The relationship of body mass index to setup errors, dosimetric parameters and incidence of radiation pneumonitis in non-small cell lung cancer patients undergoing intensity-modulated radiation therapy: a single-center observational study

Background The relationship among body mass index (BMI), setup error and radiation pneumonitis is not clearly illustrated. Objective The present study aimed to investigate the role of BMI in non-small cell lung cancer (NSCLC) patients’ radiation treatment, focusing on its relationship with setup error of patient positioning, the dosimetric parameters of intensity-modulated radiation therapy (IMRT) and the incidence of radiation pneumonitis. Methods This prospective observational study included 523 cases of NSCLC patients during 2020–2022. Patients were divided into different groups by different BMI. The setup error was obtained by cone beam CT (CBCT) at three positions, lateral (LAT), longitudinal (LNG) and vertical (VRT). IMRT dosimetric parameters of V 5, V 20, and mean dose were collected. Results Patients with BMI ≥28 kg/m2 showed significantly higher absolute values of LAT, LNG and VRT, higher V 5, V 20, mean dose, as well as higher total incidence of radiation pneumonitis and grade III radiation pneumonitis compared with patients with BMI <24 kg/m2 or 24–28 kg/m2. Spearman’s analysis demonstrated that the absolute values of LAT, LNG and VRT were positively correlated with BMI, and positive correlation existed among BMI, dosimetric parameters and setup errors. ROC curves showed that LAT in setup errors and V 5 in dosimetric parameters had the best diagnostic value for prediction of radiation pneumonitis. Only BMI, LAT, V 5 and V 20 were the independent risk factors for radiation pneumonitis. Conclusions Setup error caused by higher BMI might be associated with the dosimetric parameters, as well as the incidence of radiation pneumonitis in NSCLC patients.

Relationship of body mass index to percent body fat determined by deuterium isotopic dilution and impedancemetry among Tunisian schoolchildren.

This study aims to evaluate the relation of body mass index (BMI) to fat mass among children by two techniques impedancemetry and deuterium oxide dilution (D2O). This study was carried out in 156 schoolchildren aged between 8 and 11 years. The children received interrogation specifying lifestyle and food habits. Body composition was determined using the impedancemetry and D2O technique. The results showed a difference between the percentage of obese and overweight children according to BMIZ classification (30.1%), bioelectrical impedance method (14.7%) and D2O technique (42.9%). Despite the difference between the last two classifications, we found a significant correlation between body fat percentages determined by impedancemetry and D2O technique (r = 0.695, p<0.01). Bioelectrical impedance analysis underestimated %BF by 78.02% in overall children, by 70.05% in boys and by 84.73% in girls compared to D2O technique. This study has demonstrated that the percentage of overweight and obesity varied according the methods used. Further development of body composition methods is needed in children for the real determination of the obesity prevalence and therefore a better monitoring of this public health problem.

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA. Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women. Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data. Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups. Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.

Physiological association of the breakpoint with the duration of hyperventilation.

To determine the relationship of body mass index (BMI) with breath-holding time (BHT) as well as that of BHT with the duration of hyperventilation (DOH) in young healthy adults. An observational study was performed at Shalamar Medical and Dental College, Lahore, Pakistan, between May 2021 and June 2022. Healthy first-year Bachelor of Medicine, Bachelor of Surgery students aged 18-22 years, with a normal BMI were included. Spirometric measurements were taken through a spirometer pod connected to a pneumotachometer (model: Power Lab 26T). Body mass index was calculated as the weight (kg) to height (m2) ratio. Pearson correlation, linear regression, and t tests were applied using SPSS. A total of 101 subjects participated, comprising of 44 men and 57 women. A weak negative association was found between BMI and BHT in all subjects (r= -0.08, p=0.34), in men (r= -0.24, p=0.11), and in women (r= -0.092, p=0.497). Furthermore, a strong association was observed between BHT and DOH in all subjects (r=0.64, p=0.000), in men (r=0.604, p=0.000), and in women (r=0.518, p=0.000). Moreover, a nonsignificant weak inverse linear regression was found between the BMI and BHT of all subjects (β= -0.087, p=0.38), of men (β= -0.241, p=0.11), and of women (β= -0.092, p=0.49). Lastly, a significantly strong positive regression was observed between the BHT and DOH of all subjects (β=0.637, p=0.000), of men (β=0.604, p=0.000), and of women (β=0.518, p=0.000). No association was found between BMI and BHT. A strong positive association was observed between BHT and DOH in all healthy young people.