Related Domains Research Articles

Text-Guided Molecule Generation with Diffusion Language Model

Text-guided molecule generation is a task where molecules are generated to match specific textual descriptions. Recently, most existing SMILES-based molecule generation methods rely on an autoregressive architecture. In this work, we propose the Text-Guided Molecule Generation with Diffusion Language Model (TGM-DLM), a novel approach that leverages diffusion models to address the limitations of autoregressive methods. TGM-DLM updates token embeddings within the SMILES string collectively and iteratively, using a two-phase diffusion generation process. The first phase optimizes embeddings from random noise, guided by the text description, while the second phase corrects invalid SMILES strings to form valid molecular representations. We demonstrate that TGM-DLM outperforms MolT5-Base, an autoregressive model, without the need for additional data resources. Our findings underscore the remarkable effectiveness of TGM-DLM in generating coherent and precise molecules with specific properties, opening new avenues in drug discovery and related scientific domains. Code will be released at: https://github.com/Deno-V/tgm-dlm.

Ferroelectrically tuned tunneling photodetector based on graphene/h-BN/In2Se3 heterojunction

Transition metal dichalcogenides (TMDs) show promise for photodetection across various wavelengths. However, photoconductive devices often face various limitations such as low photoresponsivity or high dark current. This study introduces a highly sensitive photodetector using a graphene/h-BN/In2Se3 heterostructure. A substantial electron barrier (2.72 eV) at the graphene/h-BN junction effectively suppresses dark current, while the small hole barrier (1.39 eV) at the h-BN/In2Se3 junction facilitates efficient tunneling of photocarriers under illumination. The photodetector demonstrates a fast response time (Tr = 15 ms, Td = 5 ms), outstanding responsivity (1.18 × 104 μA/W), and detectivity (1.74 × 1010 Jones) at 4 V bias and 637 nm light illumination. Spectral measurements reveal a broad detection range from visible to near-infrared (450–1310 nm). Furthermore, leveraging the non-volatile ferroelectric properties of In2Se3 allows modulation of the barrier height, enabling non-volatile tunable photoconductivity. This study represents a significant advancement in ferroelectric based optoelectronic detection devices, providing strong support for applications in high-performance computing, neural networks, and related domains.

Bacterial Chaperone Domain Insertions Convert Human FKBP12 into an Excellent Protein-Folding Catalyst-A Structural and Functional Analysis.

Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain. Its folding activity is low, but it could be increased by inserting the chaperone domain from the homolog SlyD of E. coli near the prolyl isomerase active site. We inserted two other chaperone domains into human FKBP12: the chaperone domain of SlpA from E. coli, and the chaperone domain of SlyD from Thermococcus sp. Both stabilized FKBP12 and greatly increased its folding activity. The insertion of these chaperone domains had no influence on the FKBP12 and the chaperone domain structure, as revealed by two crystal structures of the chimeric proteins. The relative domain orientations differ in the two crystal structures, presumably representing snapshots of a more open and a more closed conformation. Together with crystal structures from SlyD-like proteins, they suggest a path for how substrate proteins might be transferred from the chaperone domain to the prolyl isomerase domain.

Big data-driven risk decision-making and safety management in agricultural supply chains

In the era of digitization, the integration of big data technologies has become instrumental in advancing agricultural supply chain management and bolstering risk decision-making processes. Agricultural supply chains, critical to ensuring food security and bolstering rural economies, face vulnerabilities stemming from a myriad of internal and external elements, including natural disasters and market dynamics. Consequently, the urgency to adopt effective risk management strategies is paramount. Contemporary studies have explored the utilization of big data in decision-making processes specific to agricultural supply chain risks, predominantly concentrating on preliminary risk prediction and characterization. Nonetheless, there exists a shortfall in comprehensively analyzing the intricate interplay among risk factors and establishing a holistic risk management decision-making framework based on such analyses. This research addresses these deficiencies through two principal investigative components. First, this research explores the analysis of risk factors and their interrelationships in the agricultural supply chain based on a decision tree algorithm with a transition structure. This algorithm enhances decision-makers’ understanding of risk factors and their interrelationships, and guide the implementation of effective risk mitigation measures and the formulation of contingency plans. Subsequently, the research constructs a corresponding data-driven multi-criteria decision-making method, assisting managers in balancing different risk management strategies in a volatile supply chain environment, considering costs, benefits, and feasibility to formulate the optimal strategy. The innovation of this research lies in the development of a novel risk analysis tool based on the transition decision tree algorithm. This is the first time that such advanced algorithms are applied to agricultural supply chain risk management, filling a gap in the current research. The outcomes of this study not only contribute to enhancing risk management practices within agricultural supply chains but also offer novel insights and methodological tools that are applicable in research and practices across related domains.

In situ characterization of optical micro/nano fibers using scattering loss analysis

We experimentally demonstrate the in situ characterization of optical micro/nano fibers (MNFs). The MNF (test fiber, TF) is positioned on a microfiber (probe fiber, PF) and simulated for the scattering loss at various PF and TF diameters. The TF is fabricated using chemical etching technique. The PF is a conventional single-mode fiber with an outer diameter of 125 μm. We measure the scattering loss along the TF axis at various positions i.e., diameters by mounting it on the PF. The diameter profile of the TF is inferred from the measured scattering loss and correlated with its surface morphology measurement. This work demonstrates an effective, low-cost, and non-destructive method for in situ characterization of fabricated MNFs. It can detect and determine the irregularities on the surface of OMNFs. It can also be used to quantify the local evanescent field. Detecting such local points can improve studies that are carried out using these fields in various sensing and related study domains. It is simple to implement and can be accessed by all domains of researchers.

The Effect of Vocational Training on Visually Impaired People's Quality of Life.

Quality of life (QOL) is frequently utilized in clinical medicine and research to assess a patient's health status and treatment effectiveness. This study investigates the impact of vocational training on the QOL of visually impaired individuals. We employed the brief Taiwan version of the World Health Organization QOL Questionnaire (WHOQOL-BREFTW) to assess four domains: physical, psychological, social, and environmental, using a nonequivalent pretest-posttest control group design. The experimental group participated in 6 months of vocational training, including life and career reconstruction. After completing the vocational training, the average QOL score for the experimental group was 3.34 ± 0.18, while the control group had a score of 3.10 ± 0.85. The generalized estimating equation (GEE) results revealed a notable improvement of 10.81 (1.10) in the posttest overall QOL scores compared to the pretest scores in the control group. Vocational training significantly improves the overall QOL for visually impaired individuals. It is noteworthy that the psychological, social relationship, and physical health domains of WHOQOL-BREF TW exhibited the most significant improvements. This emphasizes the following: 1. professional knowledge and technical learning can enhance the abilities of the visually impaired. 2. The improvement in QOL occurs primarily at physical, psychological, and social levels. These levels involve maintaining physical health, reducing dependence on medical care, and enhancing self-care abilities for life reconstruction. 3. Integrating electronics with directional action can help to mitigate the risks associated with outdoor activities.

Physical Activity and Quality of Life among High School Teachers: A Closer Look

Background: Understanding the relationship between teachers’ physical activity (PA) and quality of life (QoL), which is impacted by work-related stress, could help develop guidelines for improvement. The purpose of this study was to investigate the impact of physical activity on high school teachers’ quality of life and the differences in QoL and PA between male and female teachers. Methods: The sample consisted of 499 respondents (193 men and 306 women), all working in the educational system. The International Physical Activity Questionnaire (short form) was used for PA assessment, and the WHOQoL questionnaire to measure QoL. Results: Physical health and Psychological health domains were areas where male teachers scored better (p < 0.01, both), while female teachers had higher scores in Social relationships domain (p < 0.05). Regression analysis showed that PA affects Physical health: Sig. = 0.056; Psychological health: Sig. = 0.000; Social relationships: Sig. = 0.001; Environment: Sig. = 0.021 in men, and Physical health (Sig. = 0.009) and Psychological health (Sig. = 0.039) in women. Conclusions: The findings of this study allow us to conclude that, whereas female teachers’ PA primarily impacts their physical and psychological domain, male teachers’ PA has an impact on their overall QoL.

Generative AI in Clinical Research: Regulatory Submissions, Clinical Data Management, and Beyond

Artificial intelligence and its subsets, such as generative artificial intelligence, have been making headlines due to their potential to accelerate the growth and expansion of various industries, including healthcare. However, the majority of application areas in healthcare revolve around diagnosing diseases, finding lead molecules for potential treatments, optimizing hospital operations, and other related aspects. This means that there are areas where the potential of these technologies is still to be realized. Examples of where such technologies could produce a significant impact across multiple elements are clinical research and its related domains, including regulatory submissions, clinical data management, clinical documentation, and other closely related areas. When artificial intelligence and its related technologies are utilized in these areas, they yield unparalleled outcomes regarding efficiency, consistency, and reproducibility. This, in turn, supports professionals involved in clinical research, like medical writers, statistical programmers, and other stakeholders, to drastically improve the speed by which they produce the initial drafts of various outputs, reduce the risk of errors that could lead to submission rejection, and optimize the overall clinical research workflow. Despite the potential of this area, the number of available solutions that support the aforementioned domains remains low. This is further complicated by the fact that there are even fewer numbers of working solutions.

Effects of an ice roller on chronic kidney disease-associated pruritus in patients receiving haemodialysis.

Chronic kidney disease-associated pruritus is a distressing symptom and has a far-reaching impact on patients' sleep and quality of life for most patients receiving haemodialysis. Traditional therapies have limited effectiveness. This study aimed to invent a self-operated ice roller and evaluate its efficacy in relieving pruritus, sleep quality, and quality of life. This study was experimental with a two-arm parallel group design. A convenient sampling method was used to recruit 60 patients receiving haemodialysis who reported pruritus (5D-Itch Scale score >5) lasting over 4 weeks in Taiwan. The participants were randomly assigned to one of two groups: the intervention group used an ice roller for 7 days, while the control group received no anti-pruritus treatment. This study was experimental with a two-arm parallel group design. The measurement instruments included the 5D-Itch Scale, Pittsburgh Sleep Quality Index and WHOQOL-BREF-Taiwan Version. The analysis of covariance, chi-square, Independent t tests,and partial Eta2 (η2 p) were used to analyse the data. The participants' mean age was 62.77 years. Application of the ice roller significantly decreased overall pruritus (p < .05; η2 p = .09) and distribution of pruritus-associated bodily parts (p = .03; η2 p = .08). There were no statistically significant differences in sleep quality and related indicators between the experimental and control groups at the study endpoint. Regarding quality of life, only the social relationship domain significantly differed between the two groups (p = .02; η2 p = .08). The ice roller can decrease pruritus and its distribution in patients receiving haemodialysis, serving as an adjunct therapy alongside conventional anti-pruritus treatments.

Effects of staged rehabilitation training on inflammatory factor levels and red blood cell distribution width followingcardiac valve replacement

BackgroundThe current study was conducted aimed atexploring the effects of staged rehabilitation training on the levels of inflammatory factors and red blood cell distribution in patients who underwent cardiac valve replacement.MethodsA total of 140 patients who underwent cardiac valve replacement at The First Hospital of Hebei Medical University between April 2021 and November 2022 were included in this study. During the postoperative rehabilitation phase, the patients were randomly assigned to either the control group or the experimental group. The experimental group received staged rehabilitation training (n = 70), while the control group received conventional care and rehabilitation suggestions without specialized staged rehabilitation training (n = 70). Informed consent was obtained from all patients prior to theirinclusion in the study. Clinical data of the patients were collected andanalyzed. RDW was measured using an automated blood cell analyzer on postoperative day 1, 14, and 28. Levels ofTNF-α, IL-6 and CRP were measured using ELISA. Quality of life was evaluated usingthe WHOQOL-BREF questionnaire. The effects of postoperative rehabilitation were assessed using the 6MWD test. The occurrence of adverse events in the postoperative periodwas alsoanalyzed.ResultsThere were no significant differences in the general characteristics of the two groups of patients (P > 0.05). On the first day after surgery, no significant differences were seen in RDW between the two groups (P > 0.05). However, on the 14th and 28th day after surgery, the experimental group exhibited a significant reduction in RDW compared to the control group (P < 0.05). On the first day after surgery, the levels of serum TNF-α, IL-6 and CRP were comparable between the two groups (P > 0.05). However, on the 14th and the 28th after surgery, the experimental group showed evidently lower levels of TNF-α, IL-6 and CRP compared to the control group (P < 0.05). The experimental group demonstrated higher scores in the domains of physical health, psychological state, social relationships, and environment in the WHOQOL-BREF questionnaire compared to the control group (P < 0.05). Furthermore, the experimental group exhibited increased average,minimum,maximum walking distances in the6-minute walking test compared to the control group (P < 0.05). There were no significant differences in the incidence of postoperative adverse events between the two groups of patients (P > 0.05).ConclusionStaged rehabilitation training exerteda positive effect on the levels of inflammatory factors and red blood cell distribution in patients following cardiac valve replacement. This type of rehabilitation training facilitated the patient’s recovery process by reducing the inflammatory response and improving the condition of red blood cells. Additionally, it enhanced the quality of life and rehabilitation outcomes for patients.

The effect of ACE cycle based instruction on geometry self-efficacy beliefs in polygons learning area

The assessment of self-regulation, which is important for the geometry learning area and can be associated with the stages of the ACE cycle, is important for success. The study was conducted to determine the effect of the ACE cycle-based learning process on students’ geometry self-efficacy beliefs in the 7th grade polygons learning area. Quasi-experimental design with pretest-posttest control group, one of the quantitative research methods, was preferred in the study. The study group consisted of a total of 46 students, 24 in the control group and 22 in the experimental group, studying in the seventh grade of a middle school in the eastern Anatolia region of Turkey. In the 4-week implementation, the lessons were conducted according to the ACE learning cycle in the experimental group, while no intervention was made in the control group. In this study, the Self-Efficacy Scale for Geometry was used as a data collection tool and independent sample t-test and dependent sample t-test were used to analyze the data. The results showed that the instruction shaped according to the ACE learning cycle was more effective on students' geometry self-efficacy beliefs in the related learning domain.

Female-Specific Refugee Trauma Impacting Psychological Wellbeing Post-Settlement: A Scoping Review of Research

Women represent approximately half of the refugee population, yet female-specific trauma pre, during, and after the refugee journey impacting post-settlement psychological wellbeing, is rarely explored. This scoping review described sources of evidence, key concepts, and gaps regarding traumatic experiences and the psychological wellbeing of women from refugee backgrounds following traumatic experiences with a particular interest in positive change post-settlement. Inclusion criteria were a) women from refugee backgrounds who experienced traumatic events throughout the refugee journey, and b) reported positive changes in their psychological wellbeing post-settlement. The systematic search strategy identified references from PsycINFO, PubMed, Embase, SCOPUS, and CINAHL databases as well as Google Scholar across 1992–2023. Ten studies were extracted, and data were mapped to study characteristics, trauma characteristics, psychological wellbeing domains, and recommendations for further studies. Findings described an emphasis on qualitative methods, utilizing interviews as a data collection technique, and recruiting participants from countries of origin or host countries with typically small populations of women from refugee backgrounds. It excluded individuals with disabilities. Traumatic experiences were signified as trauma types (refugee trauma and female-specific trauma) and trauma durations (acute trauma and prolonged trauma). Psychological wellbeing domains of autonomy, personal growth, and positive relations were the most represented, and purpose in life and self-acceptance were the least represented across the studies. Studies suggested further exploration of female-specific refugee trauma and its impacts to provide tailored support services. In conclusion, there was a paucity of studies that considered the psychological implications of experiencing female-specific refugee trauma influencing positive psychological wellbeing.

Process Mining Success Factors and Their Interrelationships

AbstractProcess mining—a suite of techniques for extracting insights from event logs of Information Systems (IS)—is increasingly being used by a wide range of organisations to improve operational efficiency. Despite extensive studies of Critical Success Factors (CSFs) in related domains, CSF studies tailored to process mining are limited. Moreover, these studies merely identify factors and do not provide essential details such as a clear conceptual understanding of success factors and their interrelationships. Through a multi-phased approach (applying published process mining case studies, conducting two in-depth case studies and expert interviews), this paper presents an empirically validated process mining CSF model and CSF interrelationships. This validated CSF model identifies ten process mining CSFs, explains how these factors relate to the process mining context and analyses their interrelationships with regard to process mining success. The findings provide a guide for organisations to invest in the right mix of CSFs for value realisation in process mining practice.

Intolerance of Uncertainty and Anxiety (but not Alexithymia) Mediate the Association Between Autistic Traits and Quality of Life.

Previous research has indicated that autistic individuals report lower quality of life (QoL) than non-autistic people. It is unclear whether it is the autism traits themselves or co-occurring thinking styles or mental health difficulties that most impair QoL. This study tested a hypothesised model to explore how 'intolerance of uncertainty' (IU), alexithymia (difficulty in identifying and describing own emotions), and anxiety play into the association between autistic traits and QoL. Online survey data were analysed from 116 autistic and 51 non-autistic adults who completed six standardised questionnaires measuring autistic traits, alexithymia, IU, anxiety and QoL (physical health, psychological health, social relations, and environment domains). The autistic group reported higher scores for alexithymia, IU and anxiety, and lower scores for QoL across domains, compared to the non-autistic group. Across the entire sample, autistic traits, alexithymia, IU and anxiety were positively correlated with one another, and negatively related to the four domains of QoL. Finally, IU and anxiety partially serially mediated the pathways from autistic traits to physical health and environment domains of QoL, and fully mediated the pathways from autistic traits to psychological health and social relations domains of QoL, across the full sample. The lower QoL experienced by autistic people may be explained in part by the mediating effect of both IU and anxiety (but not alexithymia). This study highlights the need for evidence-based interventions to address both IU and anxiety to improve QoL for autistic people/those with high levels of autistic traits.

Non-reflective hard source method for multiple physically extended sources and scattering bodies

In this paper, we focus on methodologies to inject a noise source in a numerical model of noise propagation in confined domains. This is a problem of primary importance when dealing with propagation of fluid-dynamic induced noise in confined basins, like ships at sea or wind farms. We first assess the performance of the literature hard source (HS) and transparent source methods; successively, we propose a novel method named the non-reflective HS (NRHS) method. It takes advantage of the linearity of the equation governing the propagation of acoustic waves in fluids and is based on the decomposition of the total signal in the sum of direct and reflected signals. It presents the advantages of the hard source method removing the main drawback consisting of the well-known problem of spurious reflections. To check the reliability of the HS vs the NRHS, a non-dimensional parameter (the encumbrance) has been defined, which gives a measure of the extension of the generation domain with respect to the propagation domain in relation to the principal wavelength of the acoustic waves and the presence of reflecting surfaces. The method herein developed gives accurate results in the case of a single-point source, where the literature methods behave well; more importantly, the NRHS method maintains its own accuracy when a noise source needs to be represented by a large number of points in space, situations of very practical importance where the standard methods may exhibit inaccuracy. This is a point of importance since the use of large generation domains is in favor of the accuracy of the source characterization, which can exhibit a complex directivity. The new method has been tested in a number of archetypal situations characterized by the presence of a reflecting plane, a scattering body close to the source location, and two sources placed side by side. In all cases, the method has shown its own superiority with respect to the standard HS method, still preserving the flexibility and simplicity of the latter.

Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models.

The RNA recognition motif (RRM) is the most prevalent RNA binding domain in eukaryotes and is involved in most RNA metabolism processes. Single RRM domains have a limited RNA specificity and affinity and tend to be accompanied by other RNA binding domains, frequently additional RRMs that contribute to an avidity effect. Within multi-RRM proteins, the most common arrangement are tandem RRMs, with two domains connected by a variable linker. Despite their prevalence, little is known about the features that lead to specific arrangements, and especially the role of the connecting linker. In this work, we present a novel and robust way to investigate the relative domain orientation in multi-domain proteins using inter-domain vectors referenced to a stable secondary structure element. We apply this method to tandem RRM domains and cluster experimental tandem RRM structures according to their inter-domain and linker-domain contacts, and report how this correlates with their orientation. By extending our analysis to AlphaFold2 predicted structures, with particular attention to the inter-domain predicted aligned error, we identify new orientations not reported experimentally. Our analysis provides novel insights across a range of tandem RRM orientations that may help for the design of proteins with a specific RNA binding mode.

Navigating the Scholarly Arena: Examining Disparate Research Trends and Discrepancies Across Management, Economics, Sport Management, and Sports Economics Fields

To define the research paths in the fields of management, economics, sport management, and sports economics, this research undertook a comprehensive analysis. The research was based on profile analysis of the top five researchers in each field, with careful examination of variables including gender distribution, citation metrics, H-index, and publication volumes obtained from the Google Scholar database. Strikingly, a significant finding emerged, showing the overwhelming male predominance among the top five researchers across all studied domains. In addition, there were noticeable differences in the number of citations and H-index; management and economics had better metrics than their sports-centric counterparts, namely sport management and sports economics. This study is a significant tool for deciphering the complexities of research trends and discrepancies that exist within the management, economics, sport management, and sports economics fields. This investigation adds to the corpus of current knowledge while providing a basic comprehension necessary of these disparate but related domains.

Impact of Socio-economic Status on Socio-emotional Development of Children Attending Different Early Childhood Care and Education (ECCE) Centers

The purpose of the 2018–20 study, which took place in the Karnataka state's Dharwad taluk, was to determine how children's social and emotional development was impacted by their socioeconomic status. The study's objectives were to evaluate the social and emotional development of children in both rural and urban locations, as well as to determine the impact of SES on these development factors. A total of 208 children aged between three and six years, comprising 104 from rural and 104 from urban areas, were chosen for the study. Children's social and emotional development was evaluated using the Transdiciplinary Play Based Assessment-2 instrument. The child's family's socioeconomic position was assessed using a Aggarwal Socio-economic status scale. A qualitative approach utilizing the naturalistic observation method was used to observe, analyze, and study the effects of play-based activities on social and emotional development. Naturalistic observations were produced by combining field notes from participant observation with video footage of kids playing in an unstructured manner. The findings showed that most kids in both urban and rural anganwadis were in the social and emotional development watch and worry category. The social and emotional development of children was shown to be significantly correlated with their socioeconomic level. According to the statistical analysis, preschoolers in both rural and urban areas showed a substantial relationship and difference. In both rural and urban settings, children from lower middle class families scored lower on social and emotional development and related domains than did children from upper middle class families.

G도 유치원 교사 인식을 통해 본 코로나19 이후 유아 발달 실태

Objectives This study investigated the status of early childhood development after COVID-19 based on teacher perception.&#x0D; Methods To this end, 173 public and private Gindergarten teachers located in G-do were surveyed, and the collected data were analyzed through frequency analysis, multiple response analysis, independent sample T-test, variance analysis, and mean difference test using SPSS 21.0.&#x0D; Results 81% of public and private Kindergarten teachers working in G Province recognized that COVID-19 had a significant impact on early childhood development, and the main factors affecting early childhood development were “wearing masks” and “social distancing.” Specifically, mask-wearing has caused direct difficulties in communication, social distancing, non-face-to-face distance learning, and the reduction in the number of Kindergarten attendance days. As a result, among the five Kindergarten curriculum areas, the areas that were most affected can be seen as the ‘communication domain’ and the ‘social relations domain’.&#x0D; Conclusions The measures to support early childhood development suggested by this study include the operation of various programs in each area, strengthening early childhood-connected integrated education, and administrative support in terms of personnel, budget, and structure. In addition, it was suggested that longitudinal studies for preemptive and preventive policy support, community cultural studies to strengthen communication and cooperation among early childhood education officials, and basic research to secure policy independence of early childhood education institutions need to be activated.&#x0D;

Racial discrimination and parenting perceptions among low-income Black couples.

Racism affects Black individuals in the United States through multiple institutional, social, and economic injustices. Relationship scientists have called for greater attention to the potentially harmful effects racism might exert on Black families. A small literature has begun to document negative associations between experiences of racism and romantic relationship functioning. However, even less empirical work has focused on a central relationship domain for many Black couples: parenting. The present study used cross-sectional data (N = 312 couples) from low-income Black couples who had recently had a child together. We examined associations between both partners' experiences of racial discrimination and their coparenting relationship quality and parenting stress. We next controlled for depression and relationship dedication as substantive covariates that could guide future research in this area. Actor-partner interdependence models revealed actor associations between discrimination and poorer parenting outcomes and a partner association specifically between one's partner's discrimination experience and own lower coparenting relationship quality. This partner effect was no longer significant, and actor effects were attenuated, when controlling for depression and relationship dedication, respectively. Our findings indicate that the negative effects of racial discrimination on Black couples' relationships are also apparent in the parenting domain, even above and beyond associations of individual depression and relationship dedication. These findings underscore the urgent need for more basic science to better understand the harms of racism for Black families, identify mechanisms that drive those effects, and highlight ways that clinical services can begin to address these impacts even now. (PsycInfo Database Record (c) 2024 APA, all rights reserved).