Membrane electrode assemblies (MEAs) are the key components of zero-gap CO2 electrolyzers, having various functions in the electrolysis process. The catalyst layers serve as the reaction interface, the porous transport layers ensure reactant and product transport to and from the catalysts, while the membrane is responsible for the ion transport between the two half cells. Thus, the structure of the MEA has a determining role on the electrolyzer operation. Industrial application requires large surface area electrolyzers and / or assembly of stacks. The scale-up, however, imposes different challenges on MEA preparation and on electrolyzer operation, therefore the optimal operating conditions can not necessarily be translated from small-scale (< 10 cm2) experiments.With the aim to scale-up the CO2 electrolysis to an industrially relevant level (>2500 cm2 active area), we thoroughly study the MEA components in a test electrolyzer cell having 100 cm2 active area. Currently we focus mainly on the optimization of the catalyst layers and the porous transport layers. The used electrolyzer size is already large enough that we can draw relevant conclusions for the operation of the large-scale electrolyzer, however, still offers possibility to screen a wide range of parameters.I will present selected results on how the improvement of the quality of the catalyst layers - through the optimization of the catalyst ink and the coating process- results in enhanced CO2 reduction performance. We also focus on the screening of different porous transport layers on the anode side with the long-term goal to reduce the precious metal consumption of the CO2 electrolysis. In the second part of my presentation, I will show how the operational parameters (e.g. cell temperature, humidity) affect the stability of the electrolysis. We have thoroughly investigated one of the biggest issues of the anion exchange membrane CO2 electrolysis: the carbonate precipitate formation and the related flooding phenomenon. We identified the pressure drop at the cathode side as a key test output parameter, which can serve as an early warning for the start of the undesired precipitation. When it is recognized in time, and the adequate preventive measures are applied, the lifetime of the electrolyzers can be greatly improved.