Event Abstract Back to Event The significance of sleep in disorders of consciousness Nicole Chwala-Schlegel1*, Julia Lechinger1, Theresa Stemeseder1, Katharina Weilhart1, Victor Cologan2, Steven Laureys2, Silvia Parapatics3, Georg Gruber3 and Manuel Schabus1 1 Lab for Sleep&Consciousness, Univ. of Salzburg, Germany 2 Cyclotron Research Centre, Univ. of Liège, Belgium 3 The Siesta Group, Vienna & Medical University of Vienna, Department of Psychiatry and Psychotherapy, Austria It is well known that abnormalities of sleep are extremely common in patients suffering from clinical disorders of consciousness. These patients exhibit more arousals and awakenings than healthy individuals and decreases in rapid eye movement (REM) and slow wave sleep (SWS) are common. Previous studies report that the reappearance of organized sleep elements, like stage 2 sleep spindles or K-complexes have predictive value for a good outcome. A better characterization of sleep timing and sleep architecture in this group of patients might therefore be of foremost ethical relevance. However, it appears that the very existence of sleep is a challenging issue as these patients do not show the normal behavioural, physiological and regulatory signs of sleep. Up to now we performed 24h polysomnographies in 34 patients being either in a vegetative (VS, i.e., unresponsive wakefulness) or minimally conscious state (MCS, i.e., inconsistent but discernible evidence of consciousness) following brain injury. Coma state was classified using the Coma Recovery Scale-Revised (CRS-R). Results: First analysis indicates that VS and MCS patients differ especially in REM sleep, sleep spindles and cortical desynchronization arousals. More complex sleep architecture (presence of SWS and/or REM) appears to be present in MCS as compared to VS patients (Chi² = 5.87, p = .053). Furthermore, CRS-R is associated with sleep onset latency (r16 = .58, p < .001), and spindle intensity at central and frontal recordings sites (e.g. C4, r32 = .34, p < .05). Finally the arousal index indicates to be higher in MCS than VS patients (t14 = -1.86; p = .084). Conclusion: 24hr polysomnographies should allow the identification of EEG markers which can help in assisting diagnostic processes and prognostic statements. Keywords: Neuropsychiatry, rem Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neuropsychiatric Applications Citation: Chwala-Schlegel N, Lechinger J, Stemeseder T, Weilhart K, Cologan V, Laureys S, Parapatics S, Gruber G and Schabus M (2011). The significance of sleep in disorders of consciousness. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00236 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Nicole Chwala-Schlegel, Lab for Sleep&Consciousness, Univ. of Salzburg, Salzubrg, Germany, nicole.chwala2@sbg.ac.at Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nicole Chwala-Schlegel Julia Lechinger Theresa Stemeseder Katharina Weilhart Victor Cologan Steven Laureys Silvia Parapatics Georg Gruber Manuel Schabus Google Nicole Chwala-Schlegel Julia Lechinger Theresa Stemeseder Katharina Weilhart Victor Cologan Steven Laureys Silvia Parapatics Georg Gruber Manuel Schabus Google Scholar Nicole Chwala-Schlegel Julia Lechinger Theresa Stemeseder Katharina Weilhart Victor Cologan Steven Laureys Silvia Parapatics Georg Gruber Manuel Schabus PubMed Nicole Chwala-Schlegel Julia Lechinger Theresa Stemeseder Katharina Weilhart Victor Cologan Steven Laureys Silvia Parapatics Georg Gruber Manuel Schabus Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.