Regulation Of Tumor Immunity Research Articles

Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy?

Since all T-cell-mediated immune responses require antigen presentation, antigen-presenting cells (APCs) may be of central importance for the generation and regulation of tumor immunity. This article describes approaches used to induce tumor immunity via modulation of the presentation of tumor antigen, either by tumor-antigen-exposed dendritic cells or by tumor cells engineered to act as APCs.

Effect of regional or distant lymph node removal and of splenectomy on immunologic responses in Ehrlich tumor-bearing mice.

To study the role of regional (RLN) and distant (DLN) lymph nodes and of the spleen in the regulation of tumor immunity, we monitored tumor growth in mice subjected to lymph node removal or splenectomy. We found that tumor growth was facilitated when RLN were removed before or soon after tumor inoculation and that RLN removal after extirpation of the immunizing tumor decreased the host resistance to a subsequent challenge. When splenectomy preceded tumor inoculation, tumor growth was not affected, however, marked growth inhibition was observed when splenectomy was performed 5 days after tumor inoculation. Furthermore, splenectomy combined with extirpation of the immunizing tumor increased the host resistance to a subsequent challenge. We conclude from these studies that RLN or the spleen may be of immunologic importance in the host's tumor resistance.

Mechanism by Which the Spleen May Act in Regulating Tumor Immunity After Tumor Resection<xref ref-type="fn" rid="FN2">2</xref>

Mechanism by Which the Spleen May Act in Regulating Tumor Immunity After Tumor Resection<xref ref-type="fn" rid="FN2">2</xref>