State Regulation Research Articles

REGULATION OF THE PROFESSIONAL ACTIVITY OF LEGAL CONSULTANTS

Abstract. Legal consultants are the important component of the system of ensuring legal and social protection of the population, as well as maintaining law and order and justice in society. The importance of the professional activity of these persons determines the need to establish requirements for their qualifications and for the organization of the activity itself. This article examines the historical experience and features of state and alternative regulation of the activities of legal consultants. The initial regulation of the activities of persons providing paid legal services, from 1997 to 2005, was carried out at the state level through licensing and state control, then the activities of these persons were regulated in a civil law manner. In 2018, a specialized legislative act defined the status of a legal consultant and chambers of legal consultants, as well as fixed the mechanism for self-regulation in the field of legal assistance with mandatory participation of consultants in a self-regulatory organization. The article examines the provisions of legislative acts regulating the procedure for regulating the activities of legal consultants. Currently, the state imperatively establishes regulatory requirements for the qualifications of legal consultants, and also indirectly influences their activities by exercising regulatory, implementation and control functions in relation to the chambers in which they are members. In the context of self-regulation, it is the chambers that directly affect the activities of legal consultants, since they are endowed with regulatory and supervisory powers in relation to their members. The results of this study are to identify the specifics of regulating the activities of legal consultants, through different periods, as well as to identify the individual shortcomings of the current regulatory mechanism both in legislative acts and in practice of their application, with the development of proposals to eliminate them.

Латынь и церковнославянский как языки «ученого духовенства»: к истории духовного образования в XVIII веке

In the XVIII century, the clergy went through the most important processes related to the formation of the estate; the creation of a system of spiritual education plays an important role in this process. We will look at how the idea of literacy and scholarship as mandatory components of self-image was formed among the clergy, and how the languages included in these ideas have changed over the century. Having analyzed "literacy" and "scholarship" as elements of state regulation of the number of clergy, we will consider the concepts of literacy focused on the Church Slavonic language and literature, and their transformation after the spread of regular seminary "Latin" education. The material of archival documents allows you to see the assessment of the literacy of children of the clergy at admission to the seminary, as well as to understand exactly what skills were included in this assessment. Next, we reconstruct the semantic shift that has been taking place in the attitude of the clergy to seminary education over the course of a century: what kind of learning outcomes did the parents of seminarians expect when sending their children to educational institutions, and how these formulations have changed over the century. The system of spiritual education turns out to be built in such a way as to have priority over home schooling, and Latin is in the focus of attention as the main "filter" that allows separating the "learned" clergy from the "unlearned", i.e. "illiterate. But with the spread of seminary education, the status of "scholarship" begins to be associated no longer with the Latin language, but with less common languages: European (French and German) and "theological" (Greek and Hebrew).

Problems of information security in the management of electronic waste

Subject. The study is devoted to data security issues in the disposal of electronic waste. Objectives. The focus is on the analysis of problems and world experience in ensuring user information security in the organization of electronic waste management system, according to the circular economy principles. Methods. The study rests on the content analysis of regulatory and legal documentation on electronic waste management. The information base includes standards of the Institute of Scrap Recycling Industries (ISRI), the Basel Action Network, Sustainable Electronics Recycling International (SERI), European legislation on Waste Electrical and Electronic Equipment (WEEE), and Russian standards for waste management. Results. So far, Russia has no regulations on data security issues when handling out-of-service electronic equipment, according to the circular economy principles. We propose to supplement Russian regulatory documents with aspects of information security, which will have positive effects on the confidentiality of data available on electronic media when recycling electronic waste. Conclusions. It is required to introduce strict State regulation of processes of handling information contained on electronic media. This will enhance the credibility of e-waste recycling companies with regard to information security.

Transformation of priorities of state regulation of tourism and recreation in the Russian Federation

Transformation of priorities of state regulation of tourism and recreation in the Russian Federation

Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets.

Understanding signaling patterns of transformation and controlling cell phenotypes is a challenge of current biology. Here we applied a cell State Transition Assessment and Regulation (cSTAR) approach to a perturbation dataset of single cell phosphoproteomic patterns of multiple breast cancer (BC) and normal breast tissue-derived cell lines. Following a separation of luminal, basal, and normal cell states, we identified signaling nodes within core control networks, delineated causal connections, and determined the primary drivers underlying oncogenic transformation and transitions across distinct BC subtypes. Whereas cell lines within the same BC subtype have different mutational and expression profiles, the architecture of the core network was similar for all luminal BC cells, and mTOR was a main oncogenic driver. In contrast, core networks of basal BC were heterogeneous and segregated into roughly four major subclasses with distinct oncogenic and BC subtype drivers. Likewise, normal breast tissue cells were separated into two different subclasses. Based on the data and quantified network topologies, we derived mechanistic cSTAR models that serve as digital cell twins and allow the deliberate control of cell movements within a Waddington landscape across different cell states. These cSTAR models suggested strategies of normalizing phosphorylation networks of BC cell lines using small molecule inhibitors.

The legal basis of innovative activities in the conditions of military conflict and in the period of continuous economic recovery

The conditions for the formation of the legal basis for the implementation of innovative activities of economic entities in Ukraine in the conditions of a military conflict have been studied. The factors of the legal field of innovative activity of economic entities are defined, which include: internal factors of the legal basis of innovative activity of economic entities, which combine the legal consequences of the choice of the legal form of the organization of economic entities and a set of regulatory and legal acts of an internal nature and external factors the legal basis of the innovative activity of business entities, which are based on a complex of normative and regulatory acts of the national and international level, which determine the possibilities and limitations of making and implementing management decisions in the field of innovative activity. The high dynamics of transformations of the legal field of innovative activity of economic entities became a prerequisite for the development of a mechanism for monitoring the influence of legal factors on the course of innovative activity, the advantage of which is the possibility of adjusting management decisions based on monitoring data and controlling the effectiveness of adaptive management decisions in the field of innovation activity. The shortcomings of the existing system of regulatory and legal regulation of innovation activities in Ukraine are characterized and it is substantiated that in the post-war period, during the period of economic recovery, the tools of state regulation of the innovation sphere and the mechanisms of state support for innovative projects can be implemented for the accelerated reproduction of the production sector and the recovery of the socio-economic sphere of Ukraine. It was determined that the need to ensure a safe legal field for innovative and investment activity in Ukraine determines the need to improve the system of normative and legal regulation of innovative activity, create conditions for fair competition for innovative enterprises, and create guarantees for the protection of the interests of national and foreign investors.

ЗЕМЕЛЬНІ ПРАВОПОРУШЕННЯ: РОЗМЕЖУВАННЯ КРИМІНАЛЬНОЇ, АДМІНІСТРАТИВНОЇ І ДИСЦИПЛІНАРНОЇ ВІДПОВІДАЛЬНОСТІ

The constitutional principles of a democratic and legal state guide the development of Ukraine in the direction of people’s rule and a legal state. Therefore, the subsystem of legal norms regulating homogeneous relations in the sphere of public and state maintenance of law and order acquires special importance for the materialization of formal and declarative norms about a democratic and legal state. Therefore, it is relevant to substantiate the need to separate the rules (norms) of public (public) order and disciplinary responsibility for their violation from the branches of administrative legislation into a separate branch according to the postulates of law. It is appropriate that the state regulation of behavior in public (public) places should be set out in the Code of Public Order. And the norms regulating responsibility for land, forest, air, etc. misdemeanors were transferred to the basic codes regulating legal relations in the relevant spheres of socio-economic life. At the same time, the primary task is to update and reform legislation based on the postulates and axioms of legal theories. The formation and development of civil society, organized into a democratic, social, legal state, in accordance with the principle of popular sovereignty, leads to changes in the very essence of delictological legal relations, a return to the postulates of legal theory (in the context of revived natural law). The separation of prescriptions and sanctioned customs of public order into an independent branch of law by including public rules regulating this order in its institutions forms a system of norms of public legal order. The proposed differentiation and systematization of legal responsibility is the basis for bringing the legal system into compliance with the axioms of the theory of law (jurisprudence) based on the postulates of Roman civil law. This will contribute to the improvement of both public order, in particular, and the development of civil society institutions, democracy, and the establishment of the rule of law in general. As well as the humanization of legal responsibility, the spread of educational and psychological measures of social (moral) responsibility, the strengthening of the discipline of social coexistence, the education of citizens’ self-discipline as a component of individual legal awareness. The transfer of norms regarding the responsibility for land offenses of private law officials and citizens to the basic land code will allow to systematize and separate the norms regarding the direct administrative responsibility of public law officials (state authorities, local self-government bodies) for illegal actions (inaction), land offenses in the field of management. Key words: legal responsibility, criminal offense, administrative offense, land offenses, land offenses in the field of management, public order, public misdemeanor.

Prawo małżeńskie osobowe Drugiej Rzeczypospolitej na ziemiach wschodnich dawnego zaboru rosyjskiego

The article describes the problems facing the marriage law in the eastern parts of the Second Polish Republic. These issues are mainly due to the lack of codification of matrimonial law throughout the territory of the Republic of Poland and the fact that exclusively civil jurisdiction in matrimonial matters was not implemented, as it was envisaged in Lutostański’s proposal. The decisions of ecclesiastical courts led to the creation of substantially invalid marriages and the spreading of legal bigamy. Failure to observe state regulations concerning the jurisdiction of ecclesiastical courts in dissolution or nullity cases, as well as mutual non-recognition of judgments of the ecclesiastical courts contributed to the creation of areas called “divorce meccas”. These designations referred to the Eastern Orthodox and Calvinist Church existing in the eastern territories of the Second Polish Republic. Taking into account the above, the article is intended to compare factors destabilising marriage law in the areas in question. To analyze this issue, primarily the historical and legal method was used.

Defect‐Driven Light Perception and Memristor Storage with Phase Transition in Vanadium Dioxide

AbstractTunable optical information storage is crucial in artificial retinal systems for mimicking neurobiological visual characteristics. The perception and storage of light signals rely heavily on the regulation of the conductivity states of memristor materials (e.g., transition metal oxides). Controlling light memristor behavior via defects and polymorphic phases remains underexplored and differs from traditional plasticity training via repeated testing. In this study, defect‐driven ultraviolet light perception and memristor storage with phase transitions in vanadium dioxide (VO2) thin films are presented. The effects of oxygen defects and the corresponding polymorphic phases on ultraviolet light memristors are investigated. The dependence of phonon vibrations and insulator–metal transition behavior on defect levels are revealed. Self‐doping and polymorphs enable VO2 to exhibit distinct ultraviolet memristor performance. It is anticipated that defect‐driven light memristors significantly contribute to the realization of artificial synaptic devices and the implementation of advanced electronic neuron systems.

Harmonization of Procedures in Romania with the Regulations of the EU Member States on the Limited Liability Company

The latest legislative amendments to Companies Law no. 31/1990 are expected to be well received by the business community, being described by the legislator, among others, as a relaxation of the conditions for registration and operation of the Limited Liability Company. Thus, significant changes concern the elimination of the minimum value of the share capital for this type of company, as well as the emphasis of the new provisions on the will of the shareholders regarding the transfer of shares, by removing the term of opposability to transfer provided in favour of third parties. Without claiming a thorough analysis of the matter, the article aims to highlight the most important aspects of these legislative changes.

Contrasting approaches to very highcapacity network regulation and policy: a comparative analysis of France, Portugal, Spain and the UK (2008–2020)

Purpose The purpose of this paper is to examine the factors that may have contributed to different levels of very high-capacity network (VHCN) coverage, with a particular focus on the role of regulation and State aid. Design/methodology/approach A comparative empirical study based on multiple case studies was conducted in France, Portugal, Spain and the UK. Findings Although France, Portugal and Spain initially adopted similar regulatory strategies for VHCN deployment, the outcomes differed significantly. The UK, with a more demanding regulation, achieved a residual coverage. This study highlights the importance of the regulatory approach to VHCN access in balancing private and public investment and emphasizes the importance of State aid in the policy agenda for nationwide VHCN deployment projects. Research limitations/implications Research on complex phenomena, such as the impact of regulation on investment or the effectiveness of State aid procedures, may focus on specific events to the detriment of others, which could bias the results. Practical implications The findings of this study provide insights for policymakers involved in State aid decisions and regulators by understanding the importance of timely State aid interventions, efficient governance and the impact of regulation on investment incentives. Originality/value This paper extends the literature on the impact of regulation on investment incentives and State aid as a tool to complement private investment for VHCN deployment through in-depth case studies.

C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function

Molecular glues can induce proximity between a target protein and ubiquitin ligases to induce target degradation, but strategies for their discovery remain limited. We screened 3,200 bioactive small molecules and identified that C646 requires neddylation-dependent protein degradation to induce cytotoxicity. Although the histone acetyltransferase p300 is the canonical target of C646, we provide extensive evidence that C646 directly targets and degrades Exportin-1 (XPO1). Multiple cellular phenotypes induced by C646 were abrogated in cells expressing the known XPO1C528S drug-resistance allele. While XPO1 catalyzes nuclear-to-cytoplasmic transport of many cargo proteins, it also directly binds chromatin. We demonstrate that p300 and XPO1 co-occupy hundreds of chromatin loci. Degrading XPO1 using C646 or the known XPO1 modulator S109 diminishes the chromatin occupancy of both XPO1 and p300, enabling direct targeting of XPO1 to phenocopy p300 inhibition. This work highlights the utility of drug-resistant alleles and further validates XPO1 as a targetable regulator of chromatin state.

Probiotics for oral health: a critical evaluation of bacterial strains.

Oral health is critical for total body health and well-being; however, little improvement in oral health status has occurred in the U.S. over the past 20 years. Tooth decay and gum disease remain highly prevalent, with more than 90% and 50% of adults suffering from these conditions, respectively. To combat this lack of improvement, alternative approaches to dental care are now being suggested. One such alternative therapy is probiotics for oral care. In the oral cavity, probiotic strains have been shown to reduce levels of oral pathogens, inhibit the formation of dental caries, and reduce the levels of bacteria that cause halitosis. However, as the oral care probiotic market expands, many products contain bacterial species and strains with no documented health benefits leading to confusion and mistrust among consumers and clinicians. This confusion is enhanced by the regulatory status of probiotic products which puts the onus of safety and efficacy on the manufacturer rather than a central regulatory body. The overarching goal of this review is to provide consumers and clinicians with documented evidence supporting (or refuting) the health benefits of oral care probiotics marketed for sale in the United States. This includes defining what constitutes an oral care probiotic product and a strain level analysis of candidate probiotics from the genera Streptococcus, Lactobacillus, Bifidobacterium, and Bacillus. Additionally, prebiotics and postbiotics will be discussed. Finally, a set of considerations for consumers and clinicians is provided to empower probiotic product decision making. Together, this review will improve understanding of oral care probiotics marketed in the US for dental professionals and consumers.

Boosting Electrochemical Nitrate Reduction at Low Concentrations Through Simultaneous Electronic States Regulation and Proton Provision.

Electrochemically converting nitrate (NO3 -) into ammonia (NH3) has emerged as an alternative strategy for NH3 production and effluent treatment. Nevertheless, the electroreduction of dilute NO3 - is still challenging due to the competitive adsorption between various aqueous species and NO3 -, and unfavorable water dissociation providing *H. Herein, a new tandem strategy is proposed to boost the electrochemical nitrate reduction reaction (NO3RR) performance of Cu nanoparticles supported on single Fe atoms dispersed N-doped carbon (Cu@Fe1-NC) at dilute NO3 - concentrations (≤100ppm NO3 --N). The optimized Cu@Fe1-NC presents a FENH3 of 97.7% at -0.4V versus RHE, and a significant NH3 yield of 1953.9mmolh-1gCu -1 at 100ppm NO3 --N, a record-high activity for dilute NO3RR. The metal/carbon heterojunctions in Cu@Fe1-NC enable a spontaneous electron transfer from Cu to carbon substrate, resulting in electron-deficient Cu. As a result, the electron-deficient Cu facilitates the adsorption of NO3 - compared with the pristine Cu. The adjacent atomic Fe sites efficiently promote water dissociation, providing abundant *H for the hydrogenation of *NOx e at Cu sites. The synergistic effects between Cu and single Fe atom sites simultaneously decrease the energy barrier for NO3 - adsorption and hydrogenation, thereby enhancing the overall activity of NO3 - reduction.

Monitoring of the BEPs actions plan implementation in the context of fiscal regulation: scientific substantiation of the methodology

Since January 2017, Ukraine has joined the OECD's Inclusive Framework and committed itself to implementing the BEPS Minimum Standard. The national tax system is similar in structure to the tax systems of developed countries. At the same time, the country's recognition of generally accepted standards for combating aggressive tax planning requires significant adaptation of the legal framework. Monitoring of the legislative process of implementing the BEPS Action Plan is an important area of further development of state regulation in the tax area and an effective means of achieving the proper quality of tax legislation and creating a modern and efficient tax system. The regulatory assessment of the state of national legislation will facilitate a detailed understanding and analysis of possible positive effects, achievement of results in the fight against tax evasion and base erosion, and avoidance of legal conflicts and contradictions. Monitoring the legislative process of implementing the BEPS Action Plan measures allows us to identify the necessary areas for improving the national legislative system and track the positive and negative effects of the application of legislative norms. Monitoring of regulatory legal acts is a tool for the development of future-oriented legislation, as it involves the study of legislation to obtain information necessary for assessing, forecasting, controlling and formulating recommendations for improving the regulatory framework and ensuring its optimal condition. As a member of the OECD Inclusive Framework, Ukraine has implemented the BEPS Action Plan Minimum Standard through significant adaptation of the national tax legislation and its approximation to the provisions of international tax instruments. Monitoring of the legislative process of implementing the BEPS Action Plan is an important area of development of state regulation in the tax area and an effective means of achieving the proper quality of national tax legislation and further development of an effective tax system.

Politics of International Labor Migration and the Survival of (Illegal) Brokers in Indonesia

Indonesian labor migration is a multifaceted process heavily influenced by private actors, particularly brokers who operate both within the bounds of legality as recruitment agencies and outside it as illicit recruiters. These brokers are frequently accused of exploiting Indonesian migrant workers, leading to government efforts to limit their roles. However, despite legislative efforts, such as the 2017 law aimed at restricting the roles of labor-recruiting companies and illegal brokers, these intermediaries persist. Drawing on the concept of brokerage and the Theory of Strategic Action Field, this article explains why brokers remain despite legislative challenges. This study also argues that state regulations inadvertently create structural holes, thereby providing brokers with opportunities to maintain their involvement in labor migration. Through 56 in-depth interviews with various actors—including current and former migrant workers, recruiters, recruitment agencies, civil society organizations (CSOs), and government officials—the study illuminates how the Indonesian government’s framing of "procedural migration” contains inherent loopholes. Brokers then exploited these gaps to legitimize their presence and assert control over workers’ destinies. These brokers adeptly adapt to regulatory changes and influence migration.

Maternal interoceptive focus is associated with greater reported engagement in mother-infant stroking and rocking.

Parental caregiving during infancy is primarily aimed at the regulation of infants' physiological and emotional states. Recent models of embodied cognition propose that interoception, i.e., the perception of internal bodily states, may influence the quality and quantity of parent-infant caregiving. Yet, empirical investigations into this relationship remain scarce. Across two online studies of mothers with 6- to 18-month-old infants during Covid-19 lockdowns, we examined whether mothers' self-reported engagement in stroking and rocking their infant was related to self-reported interoceptive abilities. Additional measures included retrospective accounts of pregnancy and postnatal body satisfaction, and mothers' reports of their infant's understanding of vocabulary relating to body parts. In Study 1 (N = 151) and Study 2 (N = 111), mothers reported their engagement in caregiving behaviours and their tendency to focus on and regulate bodily states. In a subsample from Study 2 (N = 49), we also obtained an objective measure of cardiac interoceptive accuracy using an online heartbeat counting task. Across both studies, the tendency to focus on and regulate interoceptive states was associated with greater mother-infant stroking and rocking. Conversely, we found no evidence for a relationship between objective interoceptive accuracy and caregiving. The findings suggest that interoception may play a role in parental engagement in stroking and rocking, however, in-person dyadic studies are warranted to further investigate this relationship.

Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes.

To explore the potential association between the KLF14 rs4731702 polymorphism and metabolic syndrome traits among patients diagnosed with type 1 diabetes (T1D). The study group included 350 patients with T1D and 250 healthy control subjects. The analysis focused on the genotyping of KLF14 rs4731702 single nucleotide polymorphism (SNP), as well as evaluating serum concentrations of inflammatory markers, blood pressure, lipid profiles, and the quantitative status of CD4 + CD25highFOXP3+ T cells. Patients with T1D carrying the T allele of KLF14 rs4731702 SNP had higher high-density lipoprotein cholesterol, lower low-density lipoprotein cholesterol, as well as lower glycated haemoglobin and serum concentration of proinflammatory markers than C allele carriers. They also developed hypertension less often than carriers of the C allele. The analysis of CD4 + CD25highFOXP3+ regulatory T-cell status based on KLF14 genotype showed that, in T1D patients, those with the TT genotype had the highest frequency of these cells compared to carriers of the CC and CT genotypes. Our study suggests that the T allele of the KLF14 rs4731702 SNP might confer a protective effect against the development of obesity, hypertension, dyslipidaemia, and chronic inflammatory state in patients diagnosed with T1D.

A critical history of child protection and welfare services for disabled children in the Republic of Ireland, 1960–2023

Existing research demonstrates at least threefold higher rates of maltreatment for disabled children than for their non-disabled peers. The situation is compounded by pervasive impediments to effective safeguarding practice for disabled children. While scholarly attention to this area is growing, one aspect remains thoroughly neglected in the Irish context, namely, historical accounts of disability and child protection are stark by their absence. This article presents key historical changes in child protection and welfare practice for disabled children from 1960 to 2023 in the Republic of Ireland. The account illustrates how discourses of risk aversion, rights and inclusion have collided with increased bureaucratisation and state regulation. Towards achieving a critical theoretical exposition of the history, conceptual conventions of the ‘5-P’ child protection model (prevention, paramountcy, partnership, protection and parental responsibility) are applied. Key lessons for policymakers and practitioners about the sociocultural construction of child protection and disability are then extracted and, with respect to informing future practice, critically explored.

Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma.

The presence of basal lineage characteristics signifies hyperaggressive human adenocarcinomas of the breast, bladder and pancreas. However, the biochemical mechanisms that maintain this aberrant cell state are poorly understood. Here we performed marker-based genetic screens in search of factors needed to maintain basal identity in pancreatic ductal adenocarcinoma (PDAC). This approach revealed MED12 as a powerful regulator of the basal cell state in this disease. Using biochemical reconstitution and epigenomics, we show that MED12 carries out this function by bridging the transcription factor ΔNp63, a known master regulator of the basal lineage, with the Mediator complex to activate lineage-specific enhancer elements. Consistent with this finding, the growth of basal-like PDAC is hypersensitive to MED12 loss when compared to PDAC cells lacking basal characteristics. Taken together, our genetic screens have revealed a biochemical interaction that sustains basal identity in human cancer, which could serve as a target for tumor lineage-directed therapeutics.