Acute Myocardial Infarction (AMI) is one of the leading causes of death in the world, and immune cells such as neutrophils and macrophages are implicated in its pathophysiology. Despite decades of research, there is much debate on the roles of these immune cells, however, new concepts are emerging. This review summaries the recent advances in our understanding of the involvement of neutrophils and macrophages in post-AMI cardiac healing. Recently, neutrophils and monocytes were found to begin their phenotypical transformation in the bone marrow following an AMI, before migration to the infarct region. Novel cytokines and feedback loops have been identified in coordinating the process of immune cell recruitment to the heart post-AMI including subsets of pro- and anti-inflammatory neutrophils and new pathways of WNT signalling that alter macrophage phenotypes to a pro-inflammatory phenotype. There is also an interplay between these cells during regulation of immune cell migration as neutrophils are involved in polarising macrophages toward a reparative archetype that promotes clearance of apoptotic cells and cellular debris. Resident macrophages in the pericardial cavity also showed a cardioprotective role which may have important implications in cardiac surgeries that involve removal of the pericardium.