In India, hilly region especially northern part is more seismically active region. Flat Slab systems are widely popular in multi-storey buildings. Flat slab building has more advantages than a regular building like fast construction, free design space, reduced floor to floor height and economical. Flat slab buildings are also being built in high seismicity region. Buildings on hilly ground are vulnerable due to their vertical and horizontal irregularity and they undergo high shear and torsion during the earthquake. Further due to short column and soft storey on uphill side has higher lateral forces that are cause to failure of buildings. In this paper, an attempt has been made to assess the seismic behavior of flat slab resting on hilly slope with soft storey and set back configuration. The methodologies have been adopted are linear dynamic analysis i.e. response spectrum analysis. Building is analyzed and designed by Etabs software. Maximum displacement, maximum inter-storey drift and storey shear are determined as response quantities. It is observed from the study that for flat slab buildings on hill slopes the storey shear is very high in the bottom columns at higher ground level, therefore extra care should be taken to design these columns for earthquake load.