The upper mantle velocity structure in various island arc-marginal sea regions of the northwestern Pacific has been studied in detail to a depth of about 640 km from the analysis of P- and S-wave travel times data of 363 earthquakes with focal depths varying from 35 to 640 km. Wave velocities were obtained at the depths of foci by using Kaila's (1969) analytical method in several units of the northwestern Pacific margin: 1.(1) Honshu-Izu Bonin-Japan Sea,2.(2) Kyushu-Shikoku,3.(3) Hokkaido,4.(4) Okhotsk Sea,5.(5) southern Kurile Islands,6.(6) northern Kurile Islands,7.(7) Kamchatka,8.(8) Ryukyu Islands, and9.(9) Taiwan-Luzon. There is substantial evidence for large lateral variations, of the order of 8–10%, in both P- and S-wave velocity structure to about 250 km depth within the subducting lithospheric slab in the northwestern Pacific margin. The P velocity determined at 40 km depth, is found to be about 8.20 km/sec in the southern Kurile Islands 7.90 km/sec in the northern Kurile Islands, and the Japanese Is., 7.80 km/sec in Kamchatka and 8.05 km/sec in the Ryukyu Islands, and Taiwan-Luzon regions. The S velocity determined at 40 km depth, in the southern Kurile Is., is also found to be relatively higher, about 4.60 km/sec, compared to all other regions in the northwestern Pacific margin where it is varying from 4.30 to 4.45 km/sec. P and S velocities determined to about 185 km depth in the southern Kurile Islands region are found to be 3–5% higher than those obtained at comparable depths in the Hokkaido island, northern Kurile Islands and Kamchatka. P. velocities, determined to a depth of about 255 km, in the Ryukyu and Taiwan-Luzon regions are quite similar and are about 5% higher on the average, than the nearly constant P velocity of 7.88 km/sec found in the Kyushu and Shikoku islands of the southwest Japan. In the southwest Japan region, both P and S wave velocities are found to remain constant to almost 255 km depth. This might be due to the presence of a large magma chamber resulting also in the extensive volcanic activity observed in southwest Japan (e.g. Sakurazima volcano).The P- and S-wave velocity-depth functions, determined in the depth range of 290–640 km, in the Okhotsk Sea region, reveal a sharp first-order velocity discontinuity at 390 km depth. The observed velocity jumps are 9.2% for P and 5.6% for S waves in this region. In the central Japan region also, comprising the Honshu and the Japan Sea, there is a sharp first-order velocity discontinuity at depths of 365 km for P and 345 km for S waves with associated velocity jumps of 8.6% for P and 4.8% for S waves. The S velocities below this discontinuity to about 640 km depth in the central Japan and the Okhotsk sea regions are found to be considerably lower. The entire area, comprising the high heat-flow regions of the marginal seas of Japan and Okhotsk, may be a high temperature/high attenuation zone extending to 640 km depth. There is no evidence for the presence of a significant low-velocity layer in the northwestern Pacific margin.