Regional Specificity Research Articles

Effect of UV exposure and natural aging on the in vitro PAHs bioaccessibility associated with tire wear particles in soil

Tire wear particles (TWP), as an emerging type of microplastics, are a significant source of contaminants in roadside soils due to their high concentration of pollutants, including polycyclic aromatic hydrocarbons (PAHs). This study explored the impact of ultraviolet (UV) exposure and natural aging on the in vitro bioaccessibility of PAHs associated with TWP in soil on a China-wide scale. Our findings suggested that UV exposure amplified the negative charge of TWP by 75 % and increased the hydrophobic groups on the particle surface. The bioaccessibility of 3- and 4-ring PAHs in TWP was significantly (p < 0.05) heightened by UV exposure. After 20 types of soils containing 2 % UV-exposed TWP underwent natural aging, the bioaccessibility of PAHs saw a significant decrease (p < 0.05) to 16–48 %, compared to 28–96 % in the unaged group. Soil pH and electrical conductivity (EC) were the two primary soil properties positively influencing the reduction of in vitro PAHs concentration and PAHs bioaccessibility. According to the prediction results, soils in southern China presented the highest potential region for the release of bioaccessible PAHs from TWP, highlighting the regional specificity of environmental impact. Our study provides valuable insights into the biological impact of PAHs associated with TWP on a regional scale, and offers scientific evidence for targeted soil risk management strategies.

Macrogenomics Reveals Effects on Marine Microbial Communities during Oplegnathus punctatus Enclosure Farming.

(1) Background: Laizhou Bay is an important aquaculture area in the north of China. Oplegnathus punctatus is one of the species with high economic benefits. In recent years, the water environment of Laizhou Bay has reached a mild eutrophication level, while microorganisms are an important group between the environment and species. In this study, we evaluated alterations in environmental elements, microbial populations, and antibiotic resistance genes (ARGs) along with their interconnections during Oplegnathus punctatus net culture. (2) Methods: A total of 142 samples from various water layers were gathered for metagenome assembly analysis. Mariculture increases the abundance of microorganisms in this culture area and makes the microbial community structure more complex. The change had more significant effects on sediment than on seawater. (3) Results: Certain populations of cyanobacteria and Candidatus Micrarchaecta in seawater, and Actinobacteria and Thaumarchaeota in sediments showed high abundance in the mariculture area. Antibiotic resistance genes in sediments were more sensitive to various environmental factors, especially oxygen solubility and salinity. (4) Conclusions: These findings highlight the complex and dynamic nature of microorganism-environment-ARG interactions, characterized by regional specificity and providing insights for a more rational use of marine resources.

Brain region-specific action of ketamine as a rapid antidepressant.

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ketamine's antidepressant action. We found that ketamine injection in depressive-like mice specifically blocks NMDARs in lateral habenular (LHb) neurons, but not in hippocampal pyramidal neurons. This regional specificity depended on the use-dependent nature of ketamine as a channel blocker, local neural activity, and the extrasynaptic reservoir pool size of NMDARs. Activating hippocampal or inactivating LHb neurons swapped their ketamine sensitivity. Conditional knockout of NMDARs in the LHb occluded ketamine's antidepressant effects and blocked the systemic ketamine-induced elevation of serotonin and brain-derived neurotrophic factor in the hippocampus. This distinction of the primary versus secondary brain target(s) of ketamine should help with the design of more precise and efficient antidepressant treatments.

Antecedents and processes leading to open innovation in SMEs

Open Innovation (OI) literature related to Small and Medium Enterprises (SMEs) has often been fragmented, hindering the effective generalisation of findings. We conducted a systematic multidisciplinary literature review to explore OI in the context of SMEs across various regions. OI research in SMEs was most common in Europe, followed by China, Korea, South East Asia, Africa, South America and the Middle East. Surprisingly, very little research has been done in the USA, Canada, and the Indian subcontinent. We aimed to identify the commonalities and regional specifics in the antecedents and processes leading to OI. The review included one hundred research articles from the Web of Science database. Our findings revealed four common antecedents of OI across the firms: Human Factors, Technology, Policy, and Heterogeneity. Additionally, we identified three standard processes that lead to the OI phenomenon: firm-level partnerships, collaboration with academia, and intermediation. Though the antecedents and processes hold across firms of different sizes, human factors, policy and heterogeneity among the antecedents and intermediation as the process holds more significance to the SMEs as a sector. This research has important implications for academia and the industry. Firstly, we have responded to the research gap by increasing the generalisation of results across the regions. Secondly, different stakeholders may look for literature that is directly relevant to them. Thirdly, SME managers need to know the specific attitudes to facilitate OI effectively. Fourthly, the importance of intermediation has been identified as an effective process leading to OI. Finally, we have categorised future research directions under different clusters.

Integrated Multi-Biomarker Responses of Juvenile Zebra Seabream (Diplodus cervinus) to Warming and Acidification Conditions

The impacts of climate change-related stressors are becoming more noticeable in the ocean, particularly in coastal marine ecosystems. Yet limited information still exists on the physiological state and ecological resilience of marine fish species, especially during their early life stages (i.e., larvae and juveniles). The present study investigated the effects of chronic exposure to seawater warming (OW; ΔT = +4 °C) and acidification (OA; ΔpH = −0.3 pH units, equivalent to pCO2~1000 µatm), acting alone or combined (OWA), on juvenile zebra seabream (Diplodus cervinus) physiological resilience, considering distinct levels of biological organization (i.e., biochemical, cell, organ and individual levels). After 60 days of exposure, both stressors, in isolation or combination, significantly decreased specific growth rate (−11% in OW, −42% in OA and −49% in OWA) and leukocyte counts (from −29% in OA and OWA up to −37% in OW) in relation to the control treatment. In addition, a decreased Fulton’s condition index (K) was observed under warming and acidification in combination (−35% in OWA). At the cell level, OW, OA and OWA triggered different biomarker responses in D. cervinus (i.e., up-regulation, down-regulation, or absence of significant effect). In general, the results are suggestive of an antagonistic effect when warming and acidification are combined. OWA yielded the highest integrated biomarker response (IBR) index value in the whole organism, muscle, brain and gills of D. cervinus juveniles, therefore suggesting that the effects of these stressors are more severe when they act together. The distinct patterns observed in each stress scenario highlight the importance of carrying out further studies adjusted to the specificities of different regions, i.e., accounting not only for the type and degree of severity of environmental stressors already felt and/or projected for that specific area, but also the physiological plasticity of species that inhabit a particular ecosystem. The gathered knowledge will allow one to determine the vulnerability of particular marine species and geographic areas and, most importantly, to draw up effective and tailor-made conservation strategies to overcome climate change impacts.

Two-Step Conservative Surgery for Complicated Forms of Diabetes-Related Foot Osteomyelitis.

Diabetes-related foot osteomyelitis (DFO) is a common yet complex condition, often complicated by concurrent soft tissue infections (STIs). This study evaluates the efficacy of a two-step conservative surgical approach, hypothesizing that it offers comparable outcomes to a one-step procedure. Conducted on a cohort of 93 patients with DFO, the study categorized cases into two types: OM1 (osteomyelitis without STI) and OM2 (osteomyelitis with STI). OM2 was further subdivided into OM2a (early diagnosis) and OM2b (late diagnosis), with OM2 patients undergoing initial soft tissue debridement followed by elective bone surgery. The results indicated no significant differences in infection recurrence or amputation rates between the two surgical approaches, with recurrence observed in 20.7% of cases and amputations in 10.8%. The two-step procedure was associated with higher inflammatory responses and greater need for antibiotics and hospital admissions. However, these factors did not translate into increased recurrence or amputation compared to the one-step procedure. The study supports the two-step approach as a safe and effective method for managing complicated DFO cases, providing a viable alternative to immediate amputation or single-stage surgery. Despite some limitations, including regional specificity and potential underdiagnosis in late-diagnosed cases, the findings offer valuable insights for clinical management and suggest further research to refine treatment protocols. The study's strengths include confirmed histopathological diagnoses and consistent follow-up, reinforcing the validity of the two-step surgical approach for complex DFO treatment.

Characteristics of opinions in the societal and non-societal domains

With the increasing availability of user opinions on the web, understanding the distinct nature of opinions in societal and non-societal contexts becomes crucial for opinion mining and sentiment analysis tasks. Societal topics, encompassing social unrest, terrorist acts, and government policies, differ significantly from non-societal topics like product reviews, movie reviews, and restaurant reviews. Given the regional specificity of societal issues and the lack of sentiment-annotated resources for them, this paper highlights the need to comprehend the differences in opinions between these domains for effective sentiment analysis. Through statistical text and network analysis, it investigates word usage, sentiment word association, and homogeneity in societal versus non-societal contexts. The study also explores graph-based analysis as a novel approach to sentiment analysis, considering its advantage in easily expanding context through the addition of nodes, as opposed to the complexity of inserting relevant tokens in text. The findings suggest that while non-societal sentiment resources might not be directly applicable to societal domains, graph-based analysis offers promising avenues for sentiment analysis in diverse societal topics.

Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity.

The mechanism underlying the reversible unconsciousness induced by general anesthetics (GA) remains unclear. Recent studies revealed the critical roles of myelin and oligodendrocytes (OLs) in higher functions of the brain. However, it is unknown whether myelin actively participates in the regulation of GA. The aim of this study is to investigate the roles and possible mechanisms of myelin in the regulation of consciousness alterations induced by isoflurane anesthesia. First, demyelination models for the entire brain and specific neural nuclei were established to investigate the potential role of myelination in the regulation of GA, as well as its possible regional specificity. c-Fos staining was then performed on the demyelinated nuclei to verify the impact of myelin loss on neuronal activity. Finally, the activity of neurons during isoflurane anesthesia in demyelinated mice was recorded by optical fiber photometric calcium signal. The related behavioral indicators and EEG were recorded and analyzed. A prolonged emergence time was observed from isoflurane anesthesia in demyelinated mice, which suggested the involvement of myelin in regulating GA. The demyelination in distinct nuclei by LPC further clarified the region-specific roles of isoflurane anesthesia regulation by myelin. The effect of demyelination on isoflurane anesthesia in the certain nucleus was consistent with that in neurons towards isoflurane anesthesia. Finally, we found that the mechanism of myelin in the modulation of isoflurane anesthesia is possibly through the regulation of neuronal activity. In brief, myelin in the distinct neural nucleus plays an essential role in regulating the process of isoflurane anesthesia. The possible mechanism of myelin in the regulation of isoflurane anesthesia is neuronal activity modification by myelin integrity during GA. Our findings enhanced the comprehension of myelin function, and offered a fresh perspective for investigating the neural mechanisms of GA.

Dissection of the Male Urethra Demonstrating Its Topographical Specificity.

The urethra is a long muscular tubular organ that changes its internal configuration as it traversesdifferent regions. Therefore, the pathology of each region is distinctive, and regional characteristics may influence exploration and treatment. We set out to perform detailed dissections of the male urethra and illustrate the regional specificity for each urethral segment. Therefore, we dissected the vesical cervix, showing both the normal appearance and the appearance of prostatic middle lobe adenoma. We dissected the prostatic urethra, showing the seminal colliculus, ejaculatory ducts, and prostatic utricle. We revealed the membranous urethra surrounded by the striated sphincter. We have shown the appearance of the spongy urethral bulb with its cul-de-sac appearance, the aspect of the urethral lacunae, the navicular fossa, and the external urethral meatus. We performed cross-sections through the prostatic urethra as well as dissection of the bulbourethral glands at the level of the urogenital diaphragm. All the information obtained through dissection is illustrated in high-quality graphic form and correlated with clinical applications, making this work valuable teaching material.

Spatial Analysis of Health System Factors in Infectious Disease Management: Lessons Learned from the COVID-19 Pandemic in Korea.

Infectious disease outbreaks present ongoing and substantial challenges to health systems at local, national, and global levels, testing their preparedness, response capabilities, and resilience. This study aimed to identify and analyze critical health system-level factors that influence infection outbreaks, focusing on the experience of the COVID-19 pandemic in Korea. Conducted as a secondary data analysis, this study utilized national datasets from Korea. Given the inherent spatial dependencies in the spread of infectious diseases, we employed a spatial lag model to analyze data. While city-specific characteristics did not emerge as significant factors, health system variables, particularly the number of community health centers and health budgets, showed significant influence on the course of the COVID-19 outbreak, along with spatial autocorrelation coefficients. Our findings underscore the importance of enhancing public healthcare infrastructure, considering regional specificities, and promoting collaboration among local governments to bolster preparedness for future outbreaks. These insights are crucial for policymakers and healthcare professionals in formulating effective strategies to prevent, manage, and mitigate the impact of infectious disease outbreaks.

Historical Prerequisites for the Formation of Legal Sovereignty of Russian Regions

The paper examines the theory of federalism in the political, administrative and territorial structure of the country. The collapse of the Soviet Union in the early 1990s caused the inclusion of the principle of national unity in the Constitution of the Russian Federation. The authors trace the dynamics of the division of powers between central and local authorities in Russia. The authors point out the importance of harmonizing the interests of the federal center and the regions, and the equal participation of all constituent entities of the Federation in state building as a guarantee of the unity of Russia. Building a competent balance in the distribution of powers between the federal center and the constituent entities of the Federation makes it possible to mitigate the contradictions that arise, which indicates the desire to ensure a balance of interests between the central government and the regions. The national authorities are working to increase the financial autonomy of the regions, giving them the right to exercise control over their funds. This approach, taking into account the differences in mentality, culture, and needs of the regions, allows for a flexible approach to the management of different constituent entities of the Federation. Increased attention to regional specifics is a vector of the policy of the modern Russian supreme power. The desire for a reasonable balance between the central government and the regions reflects the historical evolution of the Russian state structure towards genuine federalism.

Does Trust Lead to the Adoption of a Productive Climate Attitude? Relationship Between Trust, Corruption, and Climate Attitude in Developing Regions.

This study examines the relationship between institutional trust from an individual and societal perspective and perceived corruption and climate attitudes of individuals in Latin America. To this end, multilevel modeling was used to test whether the attitudes of individuals from 285 regions of Latin America are influenced by these constructs. Based on the results, it was found that in contrast to studies in developed countries, where institutional trust is positively associated with pro-climate attitudes, in Latin America institutional trust acts as an inhibiting factor and is inversely related to climate attitudes. Furthermore, the perception of corruption in public institutions was also identified as a factor inhibiting collective action to combat climate change. Moderation analysis revealed that individuals' level of education significantly influences this relationship, with a notable difference in climate attitudes between individuals with low and high levels of trust, especially among those with less education. These findings highlight the importance of taking regional specificities into account when examining the relationship between institutional trust, perceptions of corruption, and climate attitudes, and underscore the need for public policies that promote transparency and accountability of institutions to foster effective collective action on climate change.

Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle

Neuroactive steroids (i.e., sex steroid hormones and neurosteroids) are important physiological regulators of nervous function and potential neuroprotective agents for neurodegenerative and psychiatric disorders. Sex is an important component of such effects. However, even if fluctuations in sex steroid hormone level during the menstrual cycle are associated with neuropathological events in some women, the neuroactive steroid pattern in the brain across the ovarian cycle has been poorly explored. Therefore, we assessed the levels of pregnenolone, progesterone, and its metabolites (i.e., dihydroprogesterone, allopregnanolone and isoallopregnanolone), dehydroepiandrosterone, testosterone and its metabolites (i.e., dihydrotestosterone, 3α-diol and 17β-estradiol) across the rat ovarian cycle to determine whether their plasma fluctuations are similar to those occurring in the central (i.e., hippocampus and cerebral cortex) and peripheral (i.e., sciatic nerve) nervous system. Data obtained indicate that the plasma pattern of these molecules generally does not fully reflect the events occurring in the nervous system. In addition, for some neuroactive steroid levels, the pattern is not identical between the two brain regions and between the brain and peripheral nerves. Indeed, with the exception of progesterone, all other neuroactive steroids assessed here showed peculiar regional differences in their pattern of fluctuation in the nervous system during the estrous cycle. These observations may have important diagnostic and therapeutic consequences for neuropathological events influenced by the menstrual cycle.

MORTALITY FROM MALIGNANT MELANOMA IN BRAZIL BETWEEN THE YEARS 2013 AND 2022: Regional trends, in relation to gender, ethnicity and age group

Introduction: Skin cancer is the most common type of cancer in Brazil, with a high cure rate if treated early. Melanoma, an aggressive type of skin cancer, accounts for 79% of deaths from skin cancer. Its incidence is increasing globally due to sun exposure and other behavioral changes. This study analyzes mortality from cutaneous melanoma in Brazil, considering regional, gender, and ethnic factors. Methodology: Retrospective and observational study based on data from the Mortality Information System (SIM) from 2013 to 2022. Data on deaths from malignant melanoma of the skin were analyzed across various regions, genders, age groups, and ethnicities. Relevant literature selection was conducted through searches in BVS and PubMed. Results: The mortality rate from melanoma ranged from 1,547 to 1,959 deaths annually from 2013 to 2022. The Southeast region had the highest number of deaths, followed by the South and Northeast. The Southeast recorded a total of 7,821 deaths during the period, while the North had the lowest number, with 471 deaths. Men were more affected than women, accounting for 57.5% of deaths. White ethnicity accounted for 82.1% of deaths. Mortality increased progressively with age, stabilizing after age 70. Discussion: Melanoma mortality exhibited fluctuating patterns in Brazil, with peaks in 2019 and declines in 2020-2021. Regional disparities reflect differences in healthcare access, cultural habits, and socioeconomic factors. Higher mortality among men may be linked to greater exposure to risk factors and lower rates of early diagnosis. The high incidence among white individuals underscores the need for specific health policies. Preventive strategies should focus on raising awareness about sun exposure, early diagnosis, and improving healthcare infrastructure. Conclusion: The study highlights the need for public health policies tailored to regional specificities to reduce melanoma mortality in Brazil. Awareness campaigns, screening programs, and improved treatment access are essential to mitigate the effects of cutaneous melanoma.

Деякі регіональні особливості вимушеної міграції з України: столиця та інші регіони.

The forced migration of Ukrainians within the country and abroad has become a characteristic feature of the era of full-scale invasion. It saved the lives and health of many people, as a decrease in population density in the areas most affected by the hostilities leads to a decrease in human losses. Despite the great research interest in the topic of forced migration, some aspects of it still remain poorly understood, in particular, it is important to study the peculiarities of forced migration at the localities level, at least in large cities. The purpose of this article is to single out the category of forced migrants who lived in Kyiv before the full-scale invasion by the aggressor country and to identify the peculiarities of staying abroad and the attitudes of this group. To achieve this goal, general scientific methods of analysis, synthesis, and induction were used. Empirical data were collected using the method of sample surveys. The method of grouping was used to distinguish Kyiv residents from the general population of respondents, and the method of comparison was used to identify the peculiarities of their forced migration abroad. The study found that Kyiv residents are more likely to settle abroad in the capitals of their destination countries. Among them, there are more unmarried and childless individuals, which creates prerequisites for socio-economic integration outside the country. Also, people from the capital were less likely to have relatives abroad at the time of the full-scale invasion, which is likely due to their low level of participation in external labor migration in the previous period. Migrants from the capital proved to be better integrated in the countries of settlement, which is reflected in their proficiency in the local language, employment in the local labor market, and higher levels of financial well-being. At the same time, they retain stronger ties to Ukraine. Residents of Kyiv region are similar to Kyiv residents in some respects, while in others they are similar to residents of other regions. The study also revealed cases where the population of Kyiv region exhibited characteristics intermediate between Kyiv and other regions. The development of effective strategies for migration management, socio-economic development of the country during the war and post-war revival needs to take into account regional specifics.

MR Imaging Findings in Anti-Leucine-Rich Glioma Inactivated Protein 1 Encephalitis: A Systematic Review and Meta-analysis.

Antibodies against leucine-rich glioma inactivated protein 1 (LGI1) constitute a common form of autoimmune encephalitis. On MR imaging, it may show T2 FLAIR hyperintensities of the medial temporal lobe (T2 FLAIR-MTL), involve the basal ganglia, or be unremarkable. We performed a systematic review and meta-analysis to obtain prevalence estimates of abnormal findings on MR imaging in anti-LGI1 encephalitis. A human brain map of the LGI1 microarray gene expression was derived from the Allen Human Brain Atlas. PubMed and Web of Science were searched with the terms "LGI1" and "encephalitis" from inception to April 7, 2022. Thirty-one research publications, encompassing case series and retrospective cohort and case-control studies, with >10 patients with anti-LGI1 encephalitis and MR imaging data were included. Pooled prevalence estimates were calculated using Freeman-Tukey double-arcsine transformation. Meta-analysis used DerSimonian and Laird random effects models. Of 1318 patients in 30 studies, T2 FLAIR-MTL hyperintensities were present in 54% (95% CI, 0.48-0.60; I2 = 76%). Of 394 patients in 13 studies, 27% showed bilateral (95% CI, 0.19-0.36; I2 = 71%) and 24% unilateral T2 FLAIR-MTL abnormalities (95% CI, 0.17-0.32; I2 = 61%). Of 612 patients in 15 studies, basal ganglia abnormalities were present in 10% (95% CI, 0.06-0.15; I2 = 67%). LGI1 expression was highest in the amygdala, hippocampus, and caudate nucleus. Only part of the spectrum of MR imaging abnormalities in anti-LGI1 encephalitis could be included in a meta-analysis. MR imaging findings were not the main outcomes in most studies, limiting available information. I2 values ranged from 62% to 76%, representing moderate-to-large heterogeneity. T2 FLAIR-MTL hyperintensities were present in around one-half of patients with anti-LGI1. The prevalence of unilateral and bilateral presentations was similar, suggesting unilaterality should raise the suspicion of this disease in the appropriate clinical context. Around 10% of patients showed basal ganglia abnormalities, indicating that special attention should be given to this region. LGI1 regional expression coincided with the most frequently reported abnormal findings on MR imaging. Regional specificity might be partially determined by expression levels of the target protein.

Stubble burning: What determines this fire?

Despite the recognized impact of agricultural fires on air pollution and public health globally, with significant consequences observed in regions such as China, India, and Turkiye, there remains a critical gap in understanding their underlying causes. This study aims to identify the key factors influencing agricultural fires in Turkiye between 2012 and 2021. This research conducts a thorough district-level evaluation using extensive micro-level data, remote sensing datasets, and robust methodologies, including fixed effects and spatial panel data methods. The study finds that variables such as the cultivation of second-crop corn and regional conflicts positively correlate with fire occurrences. In contrast, factors like cotton cultivation, livestock presence, and forested areas are inversely related to fire incidents. These findings underscore the complicated relationship between agricultural practices, environmental factors, and socio-economic conditions influencing fire occurrences. The study's outcomes offer significant policy implications, highlighting the necessity for customized strategies to curb agricultural fires. These strategies encompass promoting alternative crop patterns, tackling socio-economic determinants, and accommodating regional specificities.

Fusion Genes Landscape of Lung Cancer Patients From Inner Mongolia, China.

Lung cancer is the leading cause of cancer-related deaths globally. Gene fusion, a key driver of tumorigenesis, has led to the identification of numerous driver gene fusions for lung cancer diagnosis and treatment. However, previous studies focused on Western populations, leaving the possibility of unrecognized lung cancer-associated gene fusions specific to Inner Mongolia due to its unique genetic background and dietary habits. To address this, we conducted DNA sequencing analysis on tumor and adjacent nontumor tissues from 1200 individuals with lung cancer in Inner Mongolia. Our analysis established a comprehensive fusion gene landscape specific to lung cancer in Inner Mongolia, shedding light on potential region-specific molecular mechanisms underlying the disease. Compared to Western cohorts, we observed a higher occurrence of ALK and RET fusions in Inner Mongolian patients. Additionally, we discovered eight novel fusion genes in three patients: SLC34A2-EPHB1, CCT6P3-GSTP1, BARHL2-APC, HRAS-MELK, FAM134B-ERBB2, ABCB1-GIPC1, GPR98-ALK, and FAM134B-SALL1. These previously unreported fusion genes suggest potential regional specificity. Furthermore, we characterized the fusion genes' structures based on breakpoints and described their impact on major functional gene domains. Importantly, the identified novel fusion genes exhibited significant clinical and pathological relevance. Notably, patients with SLC34A2-EPHB1, CCT6P3-GSTP1, and BARHL2-APC fusions showed sensitivity to the combination of chemotherapy and immunotherapy. Patients with HRAS-MELK, FAM134B-ERBB2, and ABCB1-GIPC1 fusions showed sensitivity to chemotherapy. In summary, our study provides novel insights into the frequency, distribution, and characteristics of specific fusion genes, offering valuable guidance for the development of effective clinical treatments, particularly in Inner Mongolia.

Планово-учетная деятельность и периодическая отчетность прокуратуры Кабардино-Балкарской автономной области в 1925–1926 гг.: особенности и перспективы источниковед-ческого анализа

The article is devoted to the peculiarities and prospects of the source analysis of planning and ac-counting activities and periodic reporting of the Prosecutor's office of the Kabardino-Balkarian Autonomous Region in 1925-1926. For this purpose, the plans of regional and district prosecutor's offices, checklists for collecting information on the current activities of regional prosecutor's of-fices, notebooks for recording the participation of public prosecutors in court sessions, statements on the movement of inquiries, investigative cases, cases of press revelations, monthly statements, survey reports, characteristics, literary (text) and "digital" (quantitative) reports (with elements of statistical generalization), summary reports on personnel and current activities, semi-annual re-ports on the work of the Prosecutor's office of the KBAO and district prosecutor's offices, crime reports, etc. It was established that information on the personnel composition, plans and account-ing of daily work, the management of assistants, the organization of the activities of prosecutors, the effectiveness of work with the rural population, the quality of supervisory activities, the state of crime, interaction with court authorities, criminal labor institutions, preventive activities to combat crime were subject to accounting etc. It is assumed that the analysis of the planning, ac-counting and reporting documentation of the Prosecutor's office of the KBAO in the second half of the 20s of the twentieth century has a further research perspective for studying the features of the formation and development of the mechanism of the young Soviet state and its system of law en-forcement agencies, the dynamics of the cadre and the regional specifics of supervisory activities for compliance socialist legality in the territory of the KBAO and the fight against crime, etc.

Evaluation of the Effectiveness of Digitalization Projects in the Field of Citizen Appeals, Considering Regional Specifics

The article examines the essence, goals and types of citizens' appeals, the procedure for their consideration, as well as the regulatory and organizational support of working with citizens' appeals. The issue of appeals of individuals to the executive bodies of state power in the constituent entity of the Russian Federation was considered in more detail. The problems of implementing digitalization projects in the field of receiving citizens' appeals are considered, the methodology for assessing the effectiveness of the implementation of digitalization projects in the field of receiving citizens' appeals is adapted, taking into account the specifics of the region, a comparative analysis of the implementation of digitalization projects is carried out on the example of the constituent entity of the Russian Federation, comparing the results obtained for 2020-2022.