In modern conditions, innovative infrastructure is a fundamental element for the development of a regional economic system. The availability of an efficient innovation infrastructure optimizes the process of the implementation of promising production ideas and their commercialization in the industrial sector of the region. The purpose of this study is connected with the assessment possibility of the influence level of innovations on the competitiveness of regional economic system in the context of global competition and uncertainty growth in social and production processes. The methodological basis of the study is presented by the results of research studies by domestic and foreign experts, within which a comprehensive analysis of conditions and specifics of innovative transformations in the development of the region was carried out, with the identification of promising opportunities for relevant innovations’ integration into the regional socio-economic system. In accordance with this, in the course of the study, the following general theoretical and special research methods were applied: statistical analysis, generalization, grouping, systematization, deduction, induction, and graph theory. The result of the study is the assessment of the impact of innovations on the development of the regional economic system, as well as to form the conditions for construction of innovative infrastructure and predict the results of its impact on the level of competitiveness of the region in case of its optimal integration in accordance with the functioning of national or international organizations. The results obtained can be used by state and regional authorities that provide optimal innovative development and implementation of an economically determined sequence of activities within the framework of regional innovation policy, as well as small and medium-sized production entities, scientific and educational organizations operating in the development and implementation of high-tech products with increased value.