In the current geopolitical and economic situation, the relevance of developing domestic segment of entrepreneurs is increasing due to the accelerated formation of new enterprises capable of ensuring economic stability in the Russian regions. One of the most important factors determining the prospects for such formation is the financial conditions for starting an activity. The analysis of this problem is still poorly presented in domestic scientific literature, there are no systematic studies of it. This article eliminates this gap and aims to study the impact of bank lending volume, together with attracted funds of the population as a source of financing new entrepreneurship, on the dynamics of new entries. For the period of 2012–2021, the author reveals multidirectional trends of such dynamics in the segments of commercial companies and individual entrepreneurs in the Russian regions. A significant interregional differentiation has been established both in terms of the parameters forming new enterprises and regional financial conditions. The development of negative trends in the field of SME lending is stated. A model is proposed that substantiates a significant influence of financial factors on the dynamics of business entries in the segments of commercial companies and sole proprietors. This dynamics is also influenced by a number of other economic conditions – the state of regional labor markets, the population and its real incomes, the number of economic entities, etc. Against the background of negative expectations in the economy and a decline in business activity, a sharp deterioration in the financial security of new enterprises is viewed as possible. Regional policy should stimulate the development of entrepreneurship through simplifying the access of entrepreneurs to sources of financing, reducing the cost of borrowed funds. Anti-crisis government policies of 2022 also have a certain potential to solve the problems of financing new enterprises.