The African Continental Free Trade Area Agreement (AfCFTA) represents a significant milestone in Africa's pursuit of regional integration and economic development. Envisioned as a pan-African initiative, the AfCFTA aims to establish a single market for goods and services, promote intra-African trade, and foster economic growth across the continent. This paper examines the challenges of regional integration in Africa and explores the potential benefits of the AfCFTA Agreement in addressing these challenges. This study uses qualitative research methods, with secondary data from scholarly publications, journal articles, reports from international organisations and literature studies that were thematically analysed. The results of the study shows that the challenges of integration in Africa are mostly driven by disparities in economic development and industrial capacities among African nations, persistent trade barriers, non-tariff obstacles, weak institutional frameworks, the paradox of sovereignty, and inadequate infrastructure. The study also reveals that the adoption of the AfCFTA Agreement in 2019, has brought more African nations involved in addressing these challenges of economic integration, and fostering deep cooperation within the continent. This paper concludes that the AfCFTA Agreement has the potential to be a transformative force in advancing regional integration and economic prosperity in Africa. However, a pragmatic approach is continually needed to address these challenges of integration. This paper thus recommends fostering inclusive growth and economic diversification through targeted policies that can address economic disparities among African nations. Also, emphasising the inclusion of marginalised sectors, such as small and medium-sized enterprises (SMEs) and informal traders, which is essential for maximising the AfCFTA's potential benefits and fostering sustainable economic growth. 
 
 Keywords: AfCFTA, Africa, Economic Integration, Regional Integration, Trade barriers.
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