The article discusses issues regarding regional aspects and development priorities of industrial production inTadjikistanRepublic. The contemporary state of Tadjikistan industry and its position in republic’s GNP is analyzed. Disproportions in industry development both on the country’s as well as on regional levels are disclosed. It is shown that the uneven development of regions is connected with a number of factors, including different level of adaptation to market conditions, infrastructure specificity (logistic, labor resources, energy availability etc).. Besides, the uneven development of industry in regions depends substantially on the state management, to mention only the reduced investments volume and cancellation of economy and social compensations.. The statistics reveal a negative trend in the industrial production share in GNP, the share has fallen from 38,1 % in 2001 down to 13,6 % in 2014. The mathematic models expect the forecast GNP growth to outstrip the industrial production growth, thus pointing at the necessity to secure the outstripping industry growth.. The structural disproportion in industry development in different regions presents a factor hampering to introduce management decisions aiming to enhance the innovative development of regional economy and to ensure thus the necessary stabilization of social environment in the country.