Each effective indicator depends on numerous and various factors. The more detailed is the study of the influence of factors on the magnitude of the effective indicator, the more accurate are the results of the analysis and the evaluation of the quality of the subject of the research work. Hence, in the analysis of economic activity, an important methodological issue is the study and measurement of the influence of factors on the magnitude of the economic indicators studied. The article deals with the analysis of the investment intensity of the gross regional product of the Baikal region of the Russian Federation. The author has introduced into scientific circulation the following indicators: the investment intensity of the gross regional product, the science intensity of the gross regional product and the science return of the invested capital. The paper reveals the influence of the factors affecting the investment intensity of the gross regional product in the Baikal region of the Russian Federation and provides methodological approaches to its calculation. Also, the article presents the author’s analytical and systematized statistical material for the analysis of the key indicators revealing the impact on the investment intensity of the gross regional product in the Baikal region of the Russian Federation. The paper is produced in the framework of the scientific project of the Siberian Branch of the Russian Academy of Sciences No. XI.174.1.4 “Activation of the internal development potential of regions of the resource specialization (on the example of the Baikal region)”.