The ongoing humanitarian crisis in Ukraine, intensified by the conflict that began in February 2022, has resulted in 14.7 million individuals requiring humanitarian aid by 2024. This crisis has led to significant socioeconomic challenges, with households adopting various coping strategies to manage economic stress. Understanding these strategies and their regional variations is crucial for effective crisis response and resource allocation. The purpose of the article. To analyze and present findings on the coping strategies adopted by Ukrainian households in response to the ongoing humanitarian crisis and conflict, with a particular focus on regional differences and the most severely affected areas. The object of the research. Household coping strategies across different regions of Ukraine, including selling assets, spending savings, purchasing food on credit, seeking additional employment, reducing health and education expenditures, and using degrading income sources. The methods of the research. The study employed a quantitative data collection methodology developed by REACH, utilizing both face-to-face household surveys and computer-assisted telephone interviews. The dataset encompassed 10,434 interviews conducted at the household level across 23 oblasts, targeting a 95% confidence level and an 8% margin of error. The hypothesis of the research. The research appears to hypothesize that there are significant regional variations in the adoption of coping strategies, with areas closer to the conflict zone experiencing more severe economic stress and resorting to more extreme coping measures. The statement of basic materials. The research identified ten distinct coping strategies and analyzed their adoption rates across different regions of Ukraine. Eastern and southern regions, particularly Donetska, Kharkivska, Zaporizka, Khersonska, and Sumska oblasts, consistently demonstrated higher adoption rates of various coping strategies. Donetska oblast emerged as the epicenter of economic stress, with 50% of households reporting the sale of assets or spending of savings. Zaporizka oblast led in purchasing food on credit (18.63%) and reducing health expenditures (55.28%). Significant regional disparities were observed, with some oblasts showing coping strategy adoption rates far exceeding national averages. The originality and practical significance of the research. This study provides a comprehensive, region-specific analysis of household coping strategies in Ukraine during an ongoing crisis, offering valuable insights for targeted interventions. The research's practical significance lies in its potential applications for socio-economic management, including informing the design of targeted social safety nets and economic support programs, guiding efficient resource allocation based on region-specific needs, and supporting the development of tailored healthcare and education policies. Conclusions and prospects for further research. It provides a baseline for monitoring and evaluating the effectiveness of future interventions and informs long-term regional development strategies and crisis response planning. By offering a nuanced understanding of how different regions are coping with the crisis, this research enables policymakers to develop more effective, localized approaches to addressing Ukraine's complex humanitarian challenges.