COVID-19 has significantly impacted the health systems of developed countries, leading to a surge in the demand for medical supplies and equipment. This study is dedicated to shedding light on Türkiye's health diplomacy practices and its pivotal role as a facilitator in addressing the escalating global humanitarian and medical aid demand for medical equipment, supplies, medicines, and vaccines due to COVID-19. The study employs the PRISMA systematic analysis method as a data collection protocol to scrutinize Türkiye's international humanitarian and medical assistance during the COVID-19 pandemic in the context of health diplomacy practices. The study's findings, which are categorized under four headings: international humanitarian aid based on COVID-19, international medical equipment and supplies, international ventilator aid, and Türkiye's international COVID-19 vaccine aid, reveal that Türkiye has extended a broad spectrum of medical aid and support, including ventilators, vaccines, and medical equipment, to 161 countries across five continents, demonstrating its global reach and impact. Furthermore, as a testament to its “entrepreneurial and humanitarian foreign policy,” Türkiye has underscored regional and international cooperation through its medical and humanitarian endeavors. Türkiye's international humanitarian assistance has gone beyond material aid to encourage dialogue and has been a message of international solidarity for communities. In future research, establishing a connection between Türkiye's regional and international medical assistance and tangible political, social, and economic outcomes will validate the impact and benefits of its humanitarian efforts.