Dioxins rank among the most hazardous persistent organic pollutants, presenting a serious threat due to their long environmental lifespan and capacity for bioaccumulation. This comprehensive review delves into the historical, chemical, and toxicological aspects of dioxins, spotlighting significant incidents such as the Seveso disaster and the repercussions of Agent Orange. The review offers a thorough analysis of the sources of dioxin formation, encompassing natural occurrences like volcanic eruptions and wildfires, alongside man-made activities such as industrial combustion and waste incineration. It examines regional variations in dioxin contamination, revealing air concentrations that can range from less than 0.01 pg TEQ per m3 in remote regions to as high as 2 pg TEQ per m3 in urban environments. With global dioxin emissions estimated at around 97.0 kg TEQ per year, Asia and Africa emerge as the highest emitters among the continents, with the total global dioxin release approximately at 100.4 kg TEQ annually. Dioxin emissions per capita show stark contrasts across six continents, from 10.77 g TEQ per capita in Europe to a concerning 71.66 g TEQ per capita in Oceania. Furthermore, the concentration of dioxin compounds produced during combustion varies significantly, ranging from 15 to 555 ng m-2. While dioxin emission regulations are intricate and differ globally, most nations require that concentrations remain below one ng m-2. Globally, dioxin production is estimated at 17 226 kilograms annually, equating to about 287 kilograms in toxic equivalent (TEQ). This review critically examines the severe health implications of dioxins, which include carcinogenic effects, endocrine disruption, and immunotoxicity. Innovative remediation strategies, such as using nanomaterials for adsorption and advanced oxidation processes, are identified as promising pathways to tackle this pressing issue. Ultimately, this review underscores the necessity for enhanced monitoring systems and comprehensive policy frameworks to facilitate sustainable dioxin management and regulatory compliance. Taking decisive action is vital to protect public health and the environment from the ongoing threat posed by dioxins.
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