The Tibetan Plateau (TP) exerts a profound influence on global climate change. In the boreal winter, the TP has a notable impact on the Asian winter monsoon. Nevertheless, the relationship between the TP and the climate of the remote Arctic region is not yet fully understood. The North Pacific and North Atlantic pressure systems exhibit dynamic linkages through the Aleutian Low–Icelandic Low seesaw in the boreal winter season. However, the extent to which large mountains, such as those in the TP, influence this coupling remains unclear. In this study, we conducted an orographically sensitive experiment using the Whole Atmosphere Community Climate Model Version 6. The results obtained from the model indicate that the TP influences Arctic pressure anomalies specifically via the modulation of the Aleutian Low–Icelandic Low seesaw. Specifically, the TP favors the eastward extension of a pattern resembling the Pacific–North American pattern, achieved by enhancing the horizontally propagating wave trains originating from the eastern Pacific, thus establishing a clear Aleutian Low–Icelandic Low seesaw. In addition, the TP was a critical factor in the stratosphere–troposphere coupling as it facilitated the shift of the stratospheric polar vortex towards Eurasia in a poleward direction, potentially leading to the extension of the wave train emanating from the North Pacific across North America. These results suggest that the TP significantly contributes to Arctic climate variability. This influence is observed via the TP-mediated modulation of the teleconnection between the North Pacific and North Atlantic regions and stratosphere–troposphere coupling.