Asian Region Research Articles

Sojourning and Being Well Among Contemporary Chinese Gay Men in a Tourism Destination: An Extension of Dynamic Equilibrium Theory

This study proposes an extension of the dynamic equilibrium model to investigate the intrinsic mechanisms underlying the well-being experiences of Chinese gay tourists visiting Thailand. The enhanced model incorporates elements such as stock-challenge, flow-resource, and self-concept clarity, which illuminate the intrinsic dynamics of the inner well-being framework. Findings were derived from a video ethnography conducted collaboratively by researchers and participants. The results demonstrate that the impact of sojourning on well-being among gay Chinese travelers is influenced by their typical life and travel experiences, as well as the personalized meanings they associate with tourism and well-being. These responses are intricately shaped by their personal, social, and cultural contexts. This research provides rich insights into the holiday experiences and behaviors of contemporary Chinese gay adults, emphasizing the need for the development of tailored tourism policies and marketing strategies to cultivate gay-friendly destinations within the Asia region.

The complete chloroplast genome of Calyptothecium philippinense Broth. (Pterobryaceae, Hypnales)

The genus Calyptothecium, currently comprising ca. 30 species worldwide, is the largest genus within the family Pterobryaceae. However, a comprehensive taxonomic revision of this genus is lacking. Calyptothecium philippinense Broth. 1899, a moss species widely found in the tropical regions of Asia, is characterized by the unique rugose leaves and large auriculate leaf bases. In this study, we sequenced the complete chloroplast genome (CPG) of C. philippinense using the Illumina NovaSeq 6000 platform. The length of the CPG of C. philippinense was determined to be 124,513 bp, with an AT content of 74%. The CPG of C. philippinense exhibited a standard quadripartite structure, consisting of one small single-copy (SSC) region (18,541 bp), one large single-copy region (LSC) (87,222 bp), and two inverted repeat (IR) regions (9375 bp each). A total of 126 genes from the CPG of C. philippinense were annotated, including 82 protein-coding genes, eight ribosomal RNA genes, and 36 transfer RNA genes. Phylogenetic analysis based on the CPGs of 25 bryophyte taxa revealed that the three Pterobryaceae species C. philippinense, Calyptothecium hookeri (Mitt.) Broth. and Pterobryopsis orientalis (Müll. Hal.) M. Fleisch. formed a robust clade. The findings could facilitate more accurate classification and help elucidate evolutionary relationships within Calyptothecium.

Drying trend in land and sea in East Asia during the warm season over the past four decades

Abstract The East Asian region is typically characterized by warm and humid conditions from late spring to summer. However, in recent decades, this region has experienced an increase in severe drying conditions, deviating from historical climatological patterns. This study investigated the precipitation-evaporation (P-E) trends across land and sea regions in East Asia (EA) during the extended summer season (April to September) from 1980 to 2022, and the key physical processes driving these trends through moisture budget decomposition and numerical experiments. The results reveal pronounced drying trends in southeastern China and the Yellow Sea and parts of the Korea Strait and Korean Peninsula over the past 43 years. The underlying physical processes driving these drying conditions differ between land and sea in EA. In southeastern China, the drying is driven by dynamic processes, particularly moisture divergence related to wind changes. This is linked to anomalous strengthening of descending motion due to the Indo-Pacific warm pool warming induced by both anthropogenic global warming and natural Pacific Decadal Oscillation-like sea surface temperature (SST) patterns. Conversely, drying in the Yellow Sea and adjacent areas is influenced by thermodynamic moisture advection. The altered humidity distribution due to global warming-induced SST patterns, which are higher over the Northwest Pacific marginal sea and lower in inland China, drives dry air transport from inland China to the Yellow Sea via background southwesterly wind. These findings enhance our understanding of the drying trend and their distinct processes in EA’s land and sea areas during the extended summer.

Industrially induced warming triggered synchronous intensity changes in the East Asian summer and winter monsoons

Anomalies in the East Asian monsoon system significantly disrupt the densely populated East Asian region, underscoring the importance of understanding such changes and improving current predictive abilities. On the basis of instrumental records, previous studies have shown that the East Asian winter monsoon (EAWM) and summer monsoon (EASM) interact with each other. However, owing to the lack of long-term high-resolution EAWM records, it remains unclear how and whether human activity has affected the phase relationship between the EASM and EAWM since the Industrial Revolution. In this study, we present a precisely dated high-resolution EAWM record for the last 300 years from a crater lake in northeastern China. Our results indicate that the EAWM intensity was relatively weak and fluctuated significantly between 1700 and 1850 CE. After 1850 CE, the EAWM strengthened rapidly and exceeded its intensity observed at the end of the Little Ice Age. In addition, a comparison of our reconstructed EAWM record with the published EASM record clearly shows in-phase variations during the Current Warm Period. We concluded that the climatic effects of industrially induced warming enhance the EAWM by slowing the Atlantic meridional overturning circulation and increasing the meridional temperature gradient, while also strengthening the EASM by increasing hemispheric meridional gradients and affecting other large-scale processes. Under the sustained intensification of human activity, the EASM and EAWM are likely to continue exhibiting synchronous variations in the future.

Cachexia in tuberculosis in South-East Asian and African regions: knowledge gaps and untapped opportunities.

Tuberculosis (TB) and cachexia are clinical entities that have a defined relationship, making them often found together. TB can lead to cachexia, while cachexia is a risk factor for TB. This article reviews cachexia in Tuberculosis patients in Southeast Asian and African regions by conducting a comprehensive literature search across electronic databases such as PubMed, Google Scholar, and Research Gate between 2013 and 2024 using keywords including 'Africa', 'cachexia', 'prevalence', 'implications', 'tuberculosis', and 'Southeast Asia. This article utilized only studies that satisfied the inclusion criteria, revealing knowledge gaps and untapped opportunities for cachexia in TB across Southeast Asian and African regions. Many Southeast Asian and Western Pacific patients initially receive a tuberculosis diagnosis. Sub-Saharan African countries are among the 30 high TB burden nations, according to the WHO. Food inadequacy and heightened energy expenditure can impair the immune system, leading to latent TB and subsequently, active infection. Symptoms needing attention: shortness of breath, productive cough, hyponatremia at 131mmol/l, hypoalbuminemia at 2.1g/dl, elevated aspartate transaminase at 75U/l, increased lactate dehydrogenase at 654, and normocytic anemia. Comorbidities, such as kidney disease, cardiovascular disease, and asthma, can influence the nutritional status of individuals with TB. While efforts like screening, contact tracing, and utilizing gene Xpert to detect TB cases were implemented, only a few proved effective. It is essential to conduct further studies, including RCTs, in Southeast Asia and Africa to evaluate and manage cachexia in TB patients.

A Systematic Review on the Epidemiology and Treatment Options of Multiple Myeloma in Asia

Multiple myeloma (MM) accounts for almost 15% of all neoplastic malignancies around the globe. This systematic review intends to analyse data on the treatment and management of MM in selected regions in Asia to identify and prioritize areas that need attention. A comprehensive review of original articles, published in English from 2005 to 2022, derived from the PubMed/MEDLINE database was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. There were 98 studies from select regions of Asia (China, India, Taiwan, Hong Kong, and Singapore) on newly diagnosed MM and relapsed/refractory MM. This review evaluated the trends in disease outcomes with the gradual shift in treatment regimens from doublet to triplet. Additionally, this review also explored autologous stem cell transplant outcome and anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy in MM patients. This is the first systematic review attempting to collect data on the utility and comparison of innovative agents and modifications in treatment regimens in the context of the Asian population. This review established that the body of evidence for the management of MM was generally of poor quality and there is a need for more versatile studies in the region. Novel and innovative drug regimens may help in combating the illness but consorted efforts by researchers, industry partners, policymakers, and the government are key factors in the long-term survival of MM patients. In the current systematic review, the authors have tried to give a comprehensive account of the available treatments, trends in MM management and prognosis for MM in Asia.

Towards global citizenship–role of cross border higher education across the ASEAN region

Towards global citizenship–role of cross border higher education across the ASEAN region

The Prevalence of Amputation in Regional Asia due to Diabetic Foot Ulcers 2024: A Systematic Review and Meta-analysis

Background: Over the past decade, the prevalence of diabetic foot ulcers (DFUs) has notably increased, posing a significant risk of foot amputation in individuals with diabetes. Purpose: This systematic review and meta-analysis aimed to determine the rates of amputation associated with DFUs in patients with diabetes mellitus. Methods: A comprehensive literature search was conducted across multiple databases, including Scopus, PubMed, Cochrane, Web of Science, DOAJ, and Google Scholar. Full-text articles related to diabetic foot ulcer amputation were reviewed and extracted for analysis. Publication Bias: Assessed using a funnel plot in Jamovi (2.0.0), indicating a likelihood of publication bias. Meta-analysis Summary: Conducted using the Joanna Briggs Institute methodology, yielding a pooled meta-analysis result of 0.027. Odds Ratio (OR): Calculated for amputation risk in DFU patients, with a 95% Confidence Interval (CI). Random Effects Model: Employed to synthesize relevant outcomes. Heterogeneity: Evaluated using the I² statistic. Forest Plots: Generated to visualize study results. Results: Eighteen studies were included in the meta-analysis, encompassing a total of 7115 DFU patients in the Asian region. Among these patients, 2730 underwent foot amputations. Amputation Rate: The incidence of foot amputation was significantly higher among DFU patients. Pooled Odds Ratio: The OR for foot amputation in DFU patients was 0.34 (95% CI: 0.23-0.46). Publication Bias: The asymmetrical funnel plot suggested a high likelihood of publication bias. Conclusion: The presence of DFUs significantly elevates the risk of foot amputation in diabetic patients. Continuous monitoring and preventive strategies are essential to mitigate this risk, particularly in the Asian population.

Association between cigarette smoking and nasopharyngeal cancer risk: a meta-analysis.

Nasopharyngeal cancer (NPC) is a relatively rare yet aggressive malignancy, primarily affecting regions of East and Southeast Asia. This study aims at providing an up-to-date quantification of the association between cigarette smoking and NPC risk, overall and by histological subsites. We conducted a systematic review and meta-analysis of case-control and cohort studies on the association between cigarette smoking and NPC risk published up to May 2023. The methodology used is original and efficient and includes both a comprehensive umbrella review and a traditional review. We estimated pooled relative risks (RR) of NPC according to smoking status, intensity, duration, and time since quitting. Among 46 eligible articles, 40 original studies were included in this meta-analysis. Compared with never smokers, the pooled RR of NPC was 1.61 for current, 1.28 for former, and 1.62 for ever smokers. The RR for ever compared with never smokers was 2.37 for squamous cell NPC and 1.06 for undifferentiated NPC. NPC risk significantly increased linearly with smoking intensity and duration, and decreased linearly with increasing time since quitting. This meta-analysis confirms the link between tobacco smoking and NPC, highlighting the significant risk posed even by moderate cigarette consumption. Additionally, our findings underscore the differential risk between squamous cell and undifferentiated subtypes of NPC, shedding light on the distinct implications for NPC prevention strategies.

Genetic Structure and Phylogeographic Divergence of Thymallus brevicephalus in the Ob‐Irtysh River Headwaters

ABSTRACTClarifying the genetic structure and population history of a species can reveal the impacts of historical climate and geological changes, providing critical insights for developing effective conservation strategies for ecologically significant fish. The Markakol grayling (Thymallus brevicephalus), an endangered species found in the Altai‐Sayan Mountain region of Central Asia, serves as an ideal model for studying these factors. In this study, populations of a grayling (Thymallus) species discovered in the upper Irtysh River headwaters in Xinjiang, China, were analyzed to assess genetic diversity and population structure. Mitochondrial DNA sequences (cytochrome b and control region), along with 10 microsatellite markers, were used to examine genetic variation. Phylogenetic and genetic distance analyses confirmed the species, long misidentified as Arctic grayling (T. arcticus), as T. brevicephalus. This species can be divided into two distinct geographic groups: eastern and western, with the Crane River acting as the boundary. The divergence between these groups likely corresponds to refugia formed during the Pleistocene glaciation of the Altai Mountains, approximately 0.48 MA (million years ago) (range: 0.30 to 0.71 Ma). High haplotype diversity (Hd > 0.5) and low nucleotide diversity (π < 0.005) suggest that, despite the species' genetic richness, T. brevicephalus remains vulnerable to genetic drift, which could threaten its long‐term survival. This vulnerability may stem from inbreeding within small refugial populations during the glacial period, followed by gradual population expansion. Our study offers novel insights into grayling populations, with results that have direct implications for management by serving as a tool for the identification of conservation units.

Editorial for the virtual special issue (VSI) “metal and metalloid contamination in soil and vegetables”

BackgroundIndustrial growth and population expansion have led to increasing contamination of soils and plants by metals and metalloids. Toxic elements such as lead, cadmium, and arsenic persist in the environment, presenting significant risks to both ecosystems and human health. This editorial introduces the Virtual Special Issue, which compiles recent studies on the infiltration of these contaminants into soils and their bioaccumulation in plants. ObjectivesThis special issue aims to explore the interaction between human activities and metal/metalloid contamination, highlight key bioaccumulation mechanisms, transfer dynamics, and assess the risks posed to human health by contaminated soils and plants. MethodsThe contributions to this issue include a variety of methodologies, both in laboratory and field settings, such as soil contamination assessments, bioaccumulation studies in plant species, and risk estimations for human exposure. ResultsThe compiled studies demonstrate significant contamination levels in soils and plants, especially in regions of Africa and Asia, where cadmium, mercury, zinc, and arsenic frequently exceed safety guidelines. These findings emphasize the urgent need for stricter contamination controls and further investigation in underrepresented regions. ConclusionThis issue provides crucial insights into metal and metalloid contamination in agricultural systems, offering evidence that can inform environmental policies and support the development of sustainable agricultural practices to mitigate contamination risks.

Phylogeographic analysis of Begomovirus coat and replication-associated proteins.

Begomoviruses are globally distributed plant pathogens that significantly limit crop production. These viruses are traditionally described according to phylogeographic distribution and categorized into two groups: begomoviruses from the Africa, Asia, Europe and Oceania (AAEO) region and begomoviruses from the Americas. Monopartite begomoviruses are more common in the AAEO region, while bipartite viruses predominate in the Americas, where the begomoviruses lack the V2/AV2 gene involved in inter-cellular movement and RNA silencing suppression found in AAEO begomoviruses. While these features are generally accepted as lineage-defining, the number of known species has doubled due to sequence-based discovery since 2010. To re-evaluate the geographic groupings after the rapid expansion of the genus, we conducted phylogenetic analyses for begomovirus species representatives of the two longest and most conserved begomovirus proteins: the coat and replication-associated proteins. Both proteins still largely support the broad AAEO and Americas begomovirus groupings, except for sweet potato-infecting begomoviruses that form an independent, well-supported clade for their coat protein regardless of the region they were isolated from. Our analyses do not support more fine-scaled phylogeographic groupings. Monopartite and bipartite genome organizations are broadly interchanged throughout the phylogenies, and the absence of the V2/AV2 gene is highly reflective of the split between Americas and AAEO begomoviruses. We observe significant evidence of recombination within the Americas and within the AAEO region but rarely between the regions. We speculate that increased globalization of agricultural trade, the invasion of polyphagous whitefly vector biotypes and recombination will blur begomovirus phylogeographic delineations in the future.

Genetic dissection and genomic prediction of drought indices in bread wheat (Triticum aestivum L.) genotypes.

Drought constitutes the main obstacle to agricultural productivity in the Central and West Asia and North Africa (CWANA) region, notably leading to substantial reductions in wheat yields due to terminal water stress. The adoption of drought-resistant wheat varieties appears to be a vital strategy to maintain wheat production in the face of climatic challenges. In this context, a study was conducted utilizing a set of 198 elite bread wheat genotypes developed at the International Center for Agricultural Research in the Dry Areas (ICARDA). This set of elite genotypes was evaluated at the Sidi Al-Aidi station in Morocco over two years (2021-2022), under rain-fed and irrigated conditions. Phenotypic assessments for grain yield and drought indices were performed, alongside genotyping the population using 15k SNP markers. These preparatory steps facilitated a genome-wide association study (GWAS) and genomic prediction, leveraging the Mixed Linear Model (MLM) to pinpoint marker-trait associations (MTAs) and candidate genes pertinent to grain yield and drought indices. The results manifested substantial variations in both grain yield and drought indices among the genotypes tested. Grain yield performance ranged from 0.34 to 2.57 t/ha under rain-fed conditions and 1.12 to 4.57 t/ha under irrigated scenarios. The comprehensive analysis identified 39 significant MTAs (p < 0.001) and 14 putative genes associated with drought indices and grain yield. Noteworthy is the marker “wsnp_Ex_c12127_19394952” on chromosome 5B, which displayed a significant correlation with grain yield in rain-fed environments. Furthermore, the most prominent marker linked to tolerance index (TOL) was “BobWhite_c42349_99”, situated on chromosome 5A and associated with the TraesCS5A02G498000 gene. This gene plays a critical role, encoding for catalase protein crucial for response to hydrogen peroxide. These markers could be used for marker-assisted selection in wheat breeding programs targeting drought tolerance.

NON-TIMBER FOREST AS AN ALTERNATIVE ECONOMIC SURVIVAL FOR INDIGENOUS COMMUNITY IN TERENGGANU, MALAYSIA: A CASE STUDY OF RATTAN

Rattan holds significant prominence as a non-timber forest product, primarily distributed and extensively traded within the Southeast Asian region. This research aims to examine the role of rattan as non-timber forest products (NTFPs) and to explore the significant economic value of rattan, in providing economic sustenance for the Orang Asli communities. The study is a case study with a mix method approach where 95 Orang Asli respondents from Kampung Sungai Berua, Hulu Terengganu, Malaysia participated. The collected data was analyzed by economic value analysis. The study found that the economic value of rattan is RM34224 per year where the highest monthly income earned by the Orang Asli is RM600 and the lowest is RM70 for each type of rattans. The Orang Asli community rely on rattan for a variety of purposes, which include selling them as raw materials, or personal use for craftsmanship, cultural practices, and the production of tools and equipment. As such, this study emphasizes the necessity of striking a balance between economic, ecological, and cultural considerations in harnessing the potential of rattan and other NTFPs to support the livelihoods and cultural heritage of Orang Asli communities.

The changing characteristics of torrential rainfall in the Huaihe River Basin from 1961 to 2020

Abstract The Huaihe River Basin (HRB) is one of the most severely affected regions by torrential rain disasters in China. However, with climate warming, it is unclear what new features torrential rain exhibits and how the main modes of torrential rain change in this region. This study analyzes the first two modes of torrential rain in the HRB from 1961 to 2020 and their driving factors. Results show that in the last 30 years, the frequency of torrential rain events in the HRB has clearly increased, especially in southern HRB region during the flood season. The first mode of torrential rain is an entire basin-wide mode, with a period of 2–3 years. The mode is primarily influenced by the low-level westerly jet stream and Jianghuai cyclones, which are closely linked to the stratospheric Quasi-Biennial Oscillation (QBO) through influencing planetary wave propagation and convective activity under different phases of QBO. The second mode is a north-south distribution mode, with a period of 4–6 years. The leading circulation system is the frontal systems. Both the East Asia/Pacific (EAP) teleconnection wave train and ENSO drive the second torrential rain mode. During El Niño years, anomalous subsidence and anticyclone in the western tropical Pacific, induced by sea surface temperature warming in the eastern tropical Pacific through the East Asia/Pacific teleconnection, can trigger the EAP wave train poleward in the East Asian region. This wave train leads to the cold-warm confrontation conducive to the second torrential rain mode.

Analysis of the strategies of China and the United States in Central Asia: a look at the "C5+1" mechanism

The subject of the study is a comparison of the policy of China and the United States in the Central Asian region within the framework of the "C5+1" model. Both the United States and China, being the major powers of the modern world, seek to protect their interests in this region. In addition to existing bilateral and multilateral dialogue platforms, the United States and China have established a C5+1 dialogue mechanism with Central Asia. This mechanism has developed differently in both countries, each of which has created its own unique model and achieved a number of diplomatic results. The methodological basis of this research consists in an integrated historical and sociological approach. The authors used a historical approach to analyze the main factual information covered in the article as a whole. The innovation of this article is to scrutinize and compare the development of the “C5+1” model in China and the United States. The conclusion is that each US government has its own strategic priorities and diplomatic plans, the US “C5+1” mechanism has developed unevenly. Compared with the US mechanism, China's mechanism is more complete and at the same time has a higher level. Both China and the United States have developed their strategies in Central Asia according to their own interests, and that the main goal of the United States' current Central Asian strategy is to create a counterweight to Russia and China. For China, preserving sovereignty and stability as well as economic development are its primary interests.

Addressing India’s alcohol misuse crisis: The urgent need for screening and brief intervention to bridge the healthcare gap

India faces a significant challenge with alcohol misuse, as evidenced by the national survey revealing that 57 million out of 160 million persons with alcohol use exhibit harmful or dependent patterns, necessitating professional assistance. The Global Status Report on Alcohol and Health (2018) indicates a rising per capita alcohol consumption in the Southeast Asian Region, with India contributing substantially. To address this, implementing policies and programs to curb hazardous alcohol use is crucial. Despite a shortage of mental health professionals in India, they remain the primary caregivers for those with alcohol-related issues. Only one in five individuals with problematic alcohol use can access professional help. I argue for adopting Screening and Brief Intervention (SBI) to bridge this healthcare gap. SBI is a concise, structured counseling approach that proves effective and scalable. It can be delivered by various healthcare providers, including doctors, nurses, counselors, and paramedics. Hence, it can be seamlessly integrated into primary care, emergency, and nonclinical settings. The efficacy of SBI extends to electronic formats, providing a scope of expansion through telehealth. The WHO advocates SBI by its SAFER initiative aimed at reducing negative alcohol-associated health and social consequences. SBI is effective across age groups, including adolescents and young adults, constituting most of India’s population. Emerging evidence suggests that SBI is acceptable, feasible, and effective in the Indian context. Universal or targeted SBI can be a pivotal tool in achieving the Sustainable Development Goals (2030) and global commitments for noncommunicable diseases, fortifying efforts to prevent and treat alcohol misuse.

LOMU Type Alkali Basalts in East Asia Sourced from Subduction Recycling of Multiple Ancient Crustal Components

Abstract The origin of alkali basalts with distinctive time-integrated low U/Pb (low μ, LOMU) from East Asia is controversial due to the complex geochemical and tectonic signatures reported from this region. We report new data on the petrology and geochemistry of the Higashi-Matsuura and Kita-Matsuura alkali basalts from Southwest Japan, which confirm the presence of a LOMU-type mantle component below the Japanese Islands, similar to East Asian intraplate volcanoes. We use whole rock geochemistry and mineral chemistry to determine mantle melting, magma evolution conditions and isotopic evolution of the LOMU mantle source. Petrological studies show that the Higashi-Matsuura alkali basalts (~3 Ma) were derived from a hydrous mantle source with ~880 μg/g H2O, at a pressure of 1.8 to 2.3 GPa at a mantle potential temperature of ~1300°C. Trace element modelling concludes that these basalts may have been generated through the hydrous upwelling and partial melting of the asthenospheric mantle containing ~15% dehydrated eclogitic component. Higashi-Matsuura alkali basalts show 206Pb/204Pb values of 17.72 to 18.04 which are among the lowest values from Southwest Japan. Relatively older (6–8 Ma) alkali basalts from the Kita-Matsuura area showing similar physicochemical characteristics, do not show LOMU-type isotopic trends. Trace element and Pb–Sr–Nd isotopic data indicate that the Higashi-Matsuura mantle component is similar to the extreme LOMU components reported from the Northeast China alkali basalts, as well as the recently discovered Petit Spot volcanoes on the Pacific Plate. We model the origin of the LOMU signature from the lowest reported Pb isotope ratios in East Asia, from intraplate alkali basalts in Northeast China. Our model suggests that at least two separate subduction events of marine sediments, at 1.8 and 2.2 Ga, are required to explain the observed Pb isotopic variation in the East Asian region. Other LOMU type basalts from East Asia, including Southwest Japan and Petit Spot, define a linear trend between the Xiaogulihe basalts and lithospheric mantle xenoliths, with 40% to 60% Pb in Higashi-Matsuura basalts being derived from the lithospheric mantle during upwelling. This suggests that the LOMU array in East Asia may have been formed by mixing between multiple ancient, subducted sediment components accumulated at the mantle transition zone for about 2 billion years, and its recent upwelling due to dehydration of the stagnant Pacific slab and related melting of the metasomatised asthenospheric mantle.

Development of the Chinese Dual Auroral Radar Network and Preliminary Results

AbstractLed by the National Space Science Center of the Chinese Academy of Sciences, we have built a Chinese dual auroral radar network in northern China, which is called the CN‐DARN. The CN‐DARN consists of three pairs of high‐frequency coherent scattering radar facilities and is one of the key parts of the Chinese Meridian Project Phase II. It has been fully constructed and started trial operations at the end of 2023. The detection range of the radar network extends longitudinally over approximately 9 hr of local times and covers the middle to high latitudes of the entire Asia region above 40. In this paper, we present the basic design of the CN‐DARN and its preliminary observations of ionospheric irregularities, subauroral polarization streams (SAPSs) and traveling ionospheric disturbances (TIDs). We also investigate its contribution to the ionospheric convection pattern of the Northern Hemisphere derived from Super Dual Auroral Radar Network (SuperDARN) observations. The results indicate that the CN‐DARN provides excellent measurements and better specifications of flows in the Asian sector, improving our understanding of the global‐scale ionospheric convection pattern in the Northern Hemisphere. These encouraging results lead us to believe that the CN‐DARN will play an important role in studies on the evolution of ionospheric irregularities, the characteristics and evolution of SAPSs, the propagation of TIDs, and global‐scale ionospheric convection dynamics.

Leveraging HIV self-testing to achieve the UNAIDS 2025 targets in the South and Southeast Asia region.

The South and Southeast Asia region has the second-highest number of people living with HIV globally. Despite progress in reducing HIV incidence and AIDS-related deaths, the region still has a long way to go in achieving the Joint United Nations Programme on HIV and AIDS (UNAIDS) 95-95-95 HIV testing, treatment and viral suppression targets. HIV self-testing (HIVST) is recommended by the World Health Organization as an additional approach to HIV testing. This paper provides a commentary on the implementation status, benefits, barriers and recommendations for HIVST implementation in South and Southeast Asia. Additionally, it presents perspectives from HIV testing service experts from 11 countries in the region to put forth recommendations to accelerate the implementation of HIVST in South and Southeast Asia. There is uneven progress in national HIVST policy development and implementation across the region. HIVST, as an additional testing approach, can help to enhance testing coverage, frequency and demand for follow-up HIV services among key populations. Key factors influencing the implementation and scale-up of HIVST include the degree of awareness of HIVST among general and key populations, the development and implementation of supportive national HIVST policies and the availability of public funding for HIVST. To address barriers and leverage enablers to HIVST implementation, generating evidence on cost-effectiveness and budget impact, developing multisectoral partnerships for market shaping, promoting differentiated and decentralized delivery models, and optimizing linkage to further testing and care are recommended. It is crucial to accelerate the implementation and scale-up of HIVST to differentiate and decentralize the delivery of HIV testing services in South and Southeast Asian countries. Sharing experiences among country experts is vital to foster the adoption of best practices and facilitate the trial-and-error process of HIVST implementation. Such collaborative approaches can help South and Southeast Asian countries attain the UNAIDS 95-95-95 targets, especially the first 95 on HIV diagnosis, and play a significant role in ending the global AIDS epidemic.