The aim of the research was to conduct a comparative study of the qualitative composition and quantitative content of macro- and microelements in the leaves of vegetable marrows of three varieties – with white, yellow and green fruits.Materials and methods. The objects of study – the leaves of vegetable marrows of three varieties – were harvested in Kharkov region in August 2018. To determine the qualitative composition and quantitative content of macro- and microelements, the atomic-emission spectroscopy method with photographic registration on the DFS-8 device was used.Results. It is established that the studied raw materials have at least 19 elements. The following elements accumulated in the vegetable marrows leaves in the largest amounts (mg/100g): potassium (4080.0–8150.0), calcium (1830.0–2630.0), silicon (510.0–2000.0), magnesium (610.0–1050.0), phosphorus (245.0–750.0), sodium (75.0–122.0), iron (10.0–92.0), aluminum (25.0–105.0), zinc (21.0–30.6) and manganese (6.6–7.9).Conclusions. As a result of atomic-emission spectroscopy with photographic registration, the element composition has been established in the vegetable marrows leaves of three varieties. 19 elements have been detected, of which the content of potassium, calcium, silicon, magnesium and sodium dominated in studied raw materials. The results indicate the prospects of studying the leaves of vegetable marrows as a source of macro- and microelements, as well as an available type of medicinal plant raw materials with a sufficient raw material base for creating new medicines on their basis.