This paper reports a novel object-detection technique in video sequences. The proposed algorithm consists of detection of objects in illuminated and occluded videos by using object features and a neural network technique. It consists of two functional modules: region-based object feature extraction and continuous detection of objects in video sequences with region features. This scheme is proposed as an enhancement of the Lowe’s scale-invariant feature transform (SIFT) object detection method. This technique solved the high computation time problem of feature generation in the SIFT method. The improvement is achieved by region-based feature classification in the objects to be detected; optimal neural network?based feature reduction is presented in order to reduce the object region feature dataset with winner pixel estimation between the video frames of the video sequence. Simulation results show that the proposed scheme achieves better overall performance than other object detection techniques, and region-based feature detection is faster in comparison to other recent techniques.